公开(公告)号：US06942777B2

公开(公告)日：2005-09-13

申请号：US09880801

申请日：2001-06-15

申请人： Shu-Hui Chen ,  Gwo-Bin Lee ,  Chung-Shi Yang ,  Yi-Hung Lin ,  Wan-Chou Sung ,  Guan-Ruey Huang

发明人： Shu-Hui Chen ,  Gwo-Bin Lee ,  Chung-Shi Yang ,  Yi-Hung Lin ,  Wan-Chou Sung ,  Guan-Ruey Huang

IPC分类号： G01N27/447 ,  C25B11/00 ,  G01N27/453

CPC分类号： G01N27/44743 ,  G01N27/44721 ,  G01N27/44791

摘要： The present invention relates to a sample analysis system with chip-based electrophoresis device, particularly, the chip electrophoresis is connected to the dynamic flow-based auto-sampling device to introduce the sample into the chip-based electrophoresis device. By utilizing the derivatization biochemistry method to have a surface modification on the sample loading channel, it prevents the sample from being adhered to the wall of the sample loading channel, and hence increases the sample loading rate, reduces cross-contamination of samples and performs specific bio-reaction by using the immobilization of matter including antigen, antibody, protein, or enzyme. This invention makes use of the continuous split flow and electric voltage control to work with the detecting unit, signal collecting unit, and signal processing unit so that the sample undergoes a timely, fast, continuous analysis without having interference from the sample of other time.

摘要翻译： 本发明涉及一种具有基于芯片的电泳装置的样品分析系统，特别地，芯片电泳连接到基于动态流量的自动采样装置，以将样品引入基于芯片的电泳装置。 通过利用衍生生物化学方法在样品加载通道上进行表面改性，可以防止样品粘附到样品加载通道的壁上，从而增加样品加载速率，减少样品的交叉污染，并执行特定的 通过使用固定化物质（包括抗原，抗体，蛋白质或酶）进行生物反应。 本发明利用连续分流和电压控制与检测单元，信号采集单元和信号处理单元一起工作，使得样品经过及时，快速，连续的分析，而不会受到其他时间样品的干扰。