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    Polyacrolein-type microspheres
    1.
    发明授权
    Polyacrolein-type microspheres 失效
    聚丙烯醛型微球

    公开(公告)号：US4783336A

    公开(公告)日：1988-11-08

    申请号：US772387

    申请日：1985-09-04

    Applicant: Shlomo Margel ,  Uzi Beitler

    Inventor： Shlomo Margel ,  Uzi Beitler

    IPC: A61K9/50 ,  A61K9/51 ,  A61K9/58 ,  A61K39/44 ,  A61K47/48 ,  C08F2/22 ,  C08F2/24 ,  C08F16/34 ,  C12N11/08 ,  G01N33/543 ,  B01J13/02

    CPC classification number: A61K9/5138 ,  A61K39/44 ,  A61K47/48176 ,  A61K9/5094 ,  C08F16/34 ,  C12N11/08 ,  G01N33/54313 ,  G01N33/5434 ,  G01N2446/20 ,  G01N2446/30 ,  G01N2446/40 ,  G01N2446/86 ,  Y10S526/909 ,  Y10T428/2989 ,  Y10T428/2998 ,  Y10T436/25375

    Abstract: Suspension polymerization of acrolein type compounds in the presence of appropriate surfactants results in the formation of microspheres in size ranging from 0.03 to 80 microns. Fluorescent and magnetic microspheres are obtained by carrying out the same polymerization in the presence of appropriate fluorochromic or ferrofluidic compounds, respectively. Hybrido-polyacrolein microspheres are obtained by grafting one type of such microspheres on another type. Immunomicrospheres were formed by binding covalently at physiological pH appropriate proteins to the microspheres. The immunomicrospheres can be used for various biological applications, such as specific markers for labeling cell surface receptors, for cell separation, for diagnostic purposes, etc.

    Abstract translation: 在适当的表面活性剂存在下丙烯醛型化合物的悬浮聚合导致尺寸范围为0.03至80微米的微球的形成。 荧光和磁性微球分别通过在适当的荧光色素或铁磁性化合物存在下进行相同的聚合而获得。 通过将一种类型的这种微球接枝在另一种类型上来获得杂环聚丙烯醛微球。 通过在生理pH适当的蛋白质上共价结合到微球体上形成免疫微球。 免疫微球可用于各种生物应用，例如用于标记细胞表面受体的特异性标记，用于细胞分离，用于诊断目的等。

    High yield process for producing polyaldehyde microspheres
    9.
    发明授权
    High yield process for producing polyaldehyde microspheres 失效
    用于生产聚醛微球的高产率工艺

    公开(公告)号：US4677138A

    公开(公告)日：1987-06-30

    申请号：US662722

    申请日：1984-10-19

    Applicant: Shlomo Margel

    Inventor： Shlomo Margel

    IPC: A61K9/50 ,  C08F16/34 ,  C08G2/02

    CPC classification number: A61K9/5094 ,  C08F16/34

    Abstract: Homopolymeric polyaldehyde microspheres can be prepared in yields of up to about 90% by preparing an aqueous solution consisting essentially of a suitable concentration of an .alpha.,.beta.-ethylenically unsaturated aldehyde and a suitable concentration of an appropriate surfactant under suitable conditions such that the surfactant has a net electrostatic charge. The solution, which may also contain a ferrofluidic material, fluorescent dye or additional solvent, is then irradiated under an inert atmosphere with a sufficient dose of .gamma.-radiation to effect polymerization and the monodisperse homopolymeric polyaldehyde microspheres so produced are recovered. Copolymeric polyaldehyde microspheres can be prepared by adding to the solution a suitable concentration of a copolymerizable comonomer before initiating polymerization.Monodisperse homopolymeric or copolymeric polyaldehyde microspheres useful for affinity chromatography, cell labeling, cell separation and diagnostic purposes can thus be prepared in significantly higher yield than was previously obtainable.

    Abstract translation: 可以通过在合适的条件下制备基本上由适当浓度的α，β-烯属不饱和醛和合适浓度的合适表面活性剂组成的水溶液，使均聚聚合物的微球的产率高达约90％ 净静电电荷。 然后可以在惰性气氛下用足够量的γ辐射照射可能还含有氟铁磁性材料，荧光染料或附加溶剂的溶液以进行聚合，并回收如此生产的单分散均聚聚醛微球。 可以在引发聚合之前向适当浓度的可共聚共聚单体中加入溶液来制备共聚的聚甲醛微球。 因此，可用于亲和层析，细胞标记，细胞分离和诊断目的的单分散均聚或共聚的聚甲醛微球以比以前可获得的显着更高的产量制备。

    Metal-coated polyaldehyde microspheres
    10.
    发明授权
    Metal-coated polyaldehyde microspheres 失效
    金属包覆的聚甲醛微球

    公开(公告)号：US4624923A

    公开(公告)日：1986-11-25

    申请号：US822774

    申请日：1986-01-24

    Applicant: Shlomo Margel

    Inventor： Shlomo Margel

    IPC: C08F8/42 ,  C08G6/00 ,  C08L5/12 ,  G01N33/534 ,  G01N33/553 ,  C12N11/14

    CPC classification number: G01N33/553 ,  C08F8/42 ,  C08G6/00 ,  C08L5/12 ,  G01N33/534 ,  Y10T428/2998

    Abstract: A metal-containing polyaldehyde microsphere composed of a polyaldehyde microsphere to which a transition metal, e.g. Au, Ag, Pt, Pd, Tc, Fe, Ni or Co, is bound may be obtained in accordance with this invention. The polyaldehyde, e.g. polyacrolein or polyglutaraldehyde, may be encapsulated in agarose, and the microsphere may be radioactive or magnetic. The microphere may additionally have a compound having at least one amine group, e.g. a drug, antibody, antigen, enzyme or other protein, bound to its surface.In one embodiment a transition metal is bound to a polyaldehyde microsphere by contacting the polyaldehyde microsphere with a suitable amount of an appropriate salt or acid of the transition metal under suitable conditions so as to cause the salt or acid to be reduced to a lower valence state and to bind to the microsphere. Some salts or acids may thus be reduced to the elemental state; others are further reduced with an appropriate reducing agent.In another embodiment, a transition metal in elemental form is bound to a polyaldehyde microsphere by contacting the polyaldehyde microsphere with a suitable amount of a compound capable of complexing with a salt or acid of the transition metal under suitable conditions permitting binding of the compound to the microsphere, contacting the compound with an appropriate amount of an appropriate salt or acid of a transition metal under appropriate conditions permitting the compound to bind to the salt or acid, and reducing the salt or acid to the corresponding elemental metal by contacting it under effective reducing conditions and for a sufficient period of time with a sufficient amount of an effective reducing agent.The metal-containing microsphere of this invention is useful for such applications as cell labeling, cell separation, diagnostic methods, catalysis and coating methods.

    Abstract translation: 由多醛微球构成的含金属的多醛微球，过渡金属，例如， Au，Ag，Pt，Pd，Tc，Fe，Ni或Co可以根据本发明得到。 多醛，例如 聚丙烯醛或聚戊二醛可以包封在琼脂糖中，微球可以是放射性的或磁性的。 微球可另外具有至少一个胺基的化合物，例如 与其表面结合的药物，抗体，抗原，酶或其它蛋白质。 在一个实施方案中，过渡金属通过在合适的条件下使聚醛微球与合适量的过渡金属的合适的盐或酸接触而与多醛微球结合，以使盐或酸被还原成较低的化合价态 并结合微球。 因此，一些盐或酸可以被还原成元素状态; 用适当的还原剂进一步还原其它物质。 在另一个实施方案中，元素形式的过渡金属通过使聚醛微球与合适量的能够与过渡金属的盐或酸络合的化合物在合适的条件下接触化合物与 微球，在合适的条件下使化合物与适当的过渡金属盐或酸接触，使化合物与盐或酸结合，并通过在有效还原下与其接触来将盐或酸还原成相应的元素金属 条件并持续足够的时间与足够量的有效的还原剂。 本发明的含金属微球可用于细胞标记，细胞分离，诊断方法，催化和涂覆方法等应用。

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