公开(公告)号：US4137307A

公开(公告)日：1979-01-30

申请号：US788921

申请日：1977-04-19

申请人： Satoshi Funakoshi ,  Takao Omura ,  Takeshi Ohshiro

发明人： Satoshi Funakoshi ,  Takao Omura ,  Takeshi Ohshiro

IPC分类号： A61L2/00 ,  C07K14/47 ,  A61K37/04 ,  A61K37/06 ,  C07G7/00

CPC分类号： A61L2/0023 ,  C07K14/47 ,  Y10S530/806 ,  Y10S530/83 ,  Y10S530/831

摘要： An aqueous solution of haptoglobin is obtained by subjecting an aqueous solution of .alpha. and .beta.-globulin fractions of human blood plasma to further fractionation by use of ammonium sulfate, collecting fractions precipitated at a concentration between 30% and 40% saturation of ammonium sulfate, contacting a reconstituted aqueous solution of the collected fractions with an anion exchanger to adsorb haptoglobin on said anion exchanger, selectively eluting the haptoglobin from the anion exchanger, and then concentrating the resulting aqueous eluate solution. The aqueous solution of haptoglobin is subjected to heat treatment in the presence of a selected stabilizing agent for inactivating hepatitis B virus at an optional step of the process.The thus obtained aqueous solution of haptoglobin has less than 10% hypotensive activity, highly stable during storage, and free from the risk of hepatitis B virus infection. This haptoglobin preparation is used for prevention and treatment of renal disorders caused by hemolysis.

摘要翻译： 接触球蛋白的水溶液是通过使人血浆的α和β-球蛋白部分的水溶液通过使用硫酸铵进一步分级而获得的，收集以硫酸铵的30％至40％饱和浓度沉淀的级分，接触 用阴离子交换剂重新收集的级分的水溶液以吸附所述阴离子交换剂上的触珠蛋白，从阴离子交换剂中选择性洗脱触珠蛋白，然后浓缩所得的水性洗脱液。 在所选择的用于灭活乙型肝炎病毒的稳定剂的存在下，在该方法的任选步骤，对触珠蛋白的水溶液进行热处理。

公开(公告)号：US4061735A

公开(公告)日：1977-12-06

申请号：US677085

申请日：1976-04-15

申请人： Satoshi Funakoshi ,  Takao Omura ,  Takeshi Ohshiro

发明人： Satoshi Funakoshi ,  Takao Omura ,  Takeshi Ohshiro

IPC分类号： A61L2/00 ,  C07K14/47 ,  A61K37/02

CPC分类号： C07K14/47 ,  A61L2/0023

摘要： An aqueous solution of haptoglobin is obtained by subjecting an aqueous solution of .alpha. and .beta.-globulin fractions of human blood plasma to further fractionation by use of ammonium sulfate, collecting fractions precipitated at a concentration between 30% and 40% saturation of ammonium sulfate, contacting a reconstituted aqueous solution of the collected fractions with an anion exchanger to adsorb haptoglobin on said anion exchanger, selectively eluting the haptoglobin from the anion exchanger, and then concentrating the resulting aqueous eluate solution. The aqueous solution of haptoglobin is subjected to heat treatment in the presence of a selected stabilizing agent for inactivating hepatitis B virus at an optional step of the process.The thus obtained aqueous solution of haptoglobin has less than 10% hypotensive activity, highly stable during storage, and free from the risk of hepatitis B virus infection. This haptoglobin preparation is used for prevention and treatment of renal disorders caused by hemolysis.

摘要翻译： 接触球蛋白的水溶液是通过使人血浆的α和β-球蛋白部分的水溶液通过使用硫酸铵进一步分级而获得的，收集以硫酸铵的30％至40％饱和浓度沉淀的级分，接触 用阴离子交换剂重新收集的级分的水溶液以吸附所述阴离子交换剂上的触珠蛋白，从阴离子交换剂中选择性洗脱触珠蛋白，然后浓缩所得的水性洗脱液。 在所选择的用于灭活乙型肝炎病毒的稳定剂的存在下，在该方法的任选步骤，对触珠蛋白的水溶液进行热处理。

公开(公告)号：US4482485A

公开(公告)日：1984-11-13

申请号：US568259

申请日：1984-01-04

申请人： Satoshi Funakoshi ,  Kazuo Morimoto ,  Morio Kuboyama ,  Nobuya Yanai ,  Muneo Yamada ,  Hajime Yokota

发明人： Satoshi Funakoshi ,  Kazuo Morimoto ,  Morio Kuboyama ,  Nobuya Yanai ,  Muneo Yamada ,  Hajime Yokota

IPC分类号： C07K14/195 ,  A61K35/22 ,  A61K38/00 ,  A61K38/16 ,  A61K38/48 ,  C07K14/005 ,  C07K14/52 ,  C07K14/53 ,  C12N9/64 ,  C07G7/00

CPC分类号： C12N9/6445 ,  A61K35/22 ,  Y10S514/929 ,  Y10S530/834

摘要： Human urine-origin colony-stimulating factor and kallikrein are separated in pure form, respectively, from an aqueous solution thereof, such as a urinary protein-concentrated solution by subjecting the solution added with a stabilizer such as octyl-phenoxypolyethoxyethanaol or polyethylene glycol both having a molecular weight of 1,000-10,000, to high-performance gel filtration effective in molecular exclusive limit of 10.sup.5 -5.times.10.sup.5 as determined with globular protein.

摘要翻译： 人尿起源的集落刺激因子和激肽释放酶分别以其形式从其水溶液例如尿蛋白浓缩溶液中分离，通过使添加有稳定剂的溶液，例如辛基 - 苯氧基聚乙氧基乙醇或聚乙二醇，其均具有 分子量为1,000-10,000，以高效凝胶过滤效果，分子量极限为105-5×105，用球状蛋白质测定。

公开(公告)号：US4340589A

公开(公告)日：1982-07-20

申请号：US237125

申请日：1981-02-18

申请人： Yahiro Uemura ,  Midori Nagatomo ,  Satoshi Funakoshi ,  Tadakazu Suyama

发明人： Yahiro Uemura ,  Midori Nagatomo ,  Satoshi Funakoshi ,  Tadakazu Suyama

IPC分类号： A61K47/16 ,  A61K9/26 ,  A61K35/14 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/48 ,  A61K38/55 ,  A61K47/02 ,  A61K47/12 ,  A61K47/18 ,  A61K47/26 ,  A61K47/42 ,  A61L2/00 ,  A61P7/02 ,  C07K14/81

CPC分类号： A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K47/26 ,  A61K47/42 ,  A61L2/0023 ,  C07K14/8128 ,  A61K38/00

摘要： An antithrombin preparation, secure and stable for a long period of time, can be obtained by freeze-drying an aqueous solution containing antithrombin-III as main component in the presence of an effective quantity of at least one member selected from the group consisting of proteins, sugars, amino acids, inorganic salts and salts of organic acids as stabilizer.

摘要翻译： PCT No.PCT / JP79 / 00154 Sec。 371日期1981年2月18日 102（e）日期1981年2月17日PCT申请日1979年6月18日PCT公布。 公开号WO80 / 02798 日期为1980年12月24日。通过在有效量的至少一种成分的存在下，将含有抗凝血酶III作为主要成分的水溶液冷冻干燥，可以长期稳定稳定的抗凝血酶制剂 选自蛋白质，糖，氨基酸，无机盐和有机酸的盐作为稳定剂。

公开(公告)号：US4587052A

公开(公告)日：1986-05-06

申请号：US578032

申请日：1984-02-08

申请人： Yasuo Ueda ,  Yusei Shiraga ,  Satoshi Morimoto ,  Yoshio Kagitani ,  Satoshi Funakoshi ,  Tadakazu Suyama

发明人： Yasuo Ueda ,  Yusei Shiraga ,  Satoshi Morimoto ,  Yoshio Kagitani ,  Satoshi Funakoshi ,  Tadakazu Suyama

IPC分类号： C07D487/04

CPC分类号： C07D487/04

摘要： Benzodiazepine derivative represented by the following general formula or pharmaceutically acceptable salt thereof: ##STR1## wherein R.sup.1 is --COR.sup.4 (R.sup.4 is a carboxylic acid residue) or an alkyl or aralkyl group (these groups have a substituent selected from a carboxyl group, an amino group and a cyano group), R.sup.2 is a lower alkyl group and R.sup.3 is a hydrogen atom or a lower alkyl group.The above compound is low in toxicity and has an antitumor activity.

摘要翻译： 由下列通式表示的苯并二氮杂衍生物或其药学上可接受的盐：其中R 1为-COR 4（R 4为羧酸残基）或烷基或芳烷基（这些基团具有选自羧基，氨基 基和氰基），R2是低级烷基，R3是氢原子或低级烷基。 上述化合物的毒性低，具有抗肿瘤活性。

公开(公告)号：US4337256A

公开(公告)日：1982-06-29

申请号：US107613

申请日：1979-12-27

申请人： Yasushi Suzuki ,  Kunio Tsukamoto ,  Nobuyoshi Minami ,  Yukio Hasegawa ,  Michitaka Satoh ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Satoshi Funakoshi

发明人： Yasushi Suzuki ,  Kunio Tsukamoto ,  Nobuyoshi Minami ,  Yukio Hasegawa ,  Michitaka Satoh ,  Norio Yamamoto ,  Katsuhiko Miyasaka ,  Takashi Mikami ,  Satoshi Funakoshi

IPC分类号： C07D217/02 ,  A61K31/47 ,  A61K31/472 ,  A61P7/02 ,  A61P25/04 ,  A61P29/00 ,  A61P43/00 ,  C07C233/12 ,  C07D217/04 ,  C07D217/12 ,  C07D217/14 ,  C07D217/16 ,  C07D217/26

CPC分类号： C07C255/00 ,  C07D217/14 ,  C07D217/16 ,  C07D217/26

摘要： Novel isoquinoline derivatives of the general formula ##STR1## wherein R represents a lower alkyl group, a lower cycloalkyl group, or a group of the formula ##STR2## in which R.sup.2 represents a hydrogen atom, a halogen atom, a methyl group, a trifluoromethyl group, a methoxy group, a methylamino group or a dimethylami no group;R.sup.1 represents a hydrogen atom or a lower alkyl group; andY represents a carboxyl group, a cyano group, a carbamoyl group, a lower alkoxycarbonyl group or a lower alkylaminocarbonyl group;or a salt thereof; a process for the production thereof.The above compound is useful as an anti-inflammatory and analgesic agent.

摘要翻译： 新的通式为（I）的异喹啉衍生物其中R表示低级烷基，低级环烷基或下式的基团：

公开(公告)号：US4314935A

公开(公告)日：1982-02-09

申请号：US175744

申请日：1980-08-06

申请人： Yahiro Uemura ,  Hirofumi Arimura ,  Hiroshi Morise ,  Satoshi Funakoshi ,  Tadakazu Suyama

发明人： Yahiro Uemura ,  Hirofumi Arimura ,  Hiroshi Morise ,  Satoshi Funakoshi ,  Tadakazu Suyama

IPC分类号： C12P21/00 ,  A61K38/21 ,  C07K1/22 ,  C07K14/52 ,  C07K14/555 ,  C07K14/56 ,  C07K14/57 ,  A61K45/02 ,  C07G7/00

CPC分类号： C07K14/555 ,  Y10S435/811 ,  Y10S530/829 ,  Y10S530/837 ,  Y10S530/838 ,  Y10S530/848

摘要： A process for recovering interferon which comprises contacting a solution containing an interferon produced by the induced cells of human origin with a water-insolubilized sulfated polysaccharide to allow the interferon to be adsorbed on the water-insolubilized sulfated polysaccharide and then selectively eluting the interferon with an aqueous solution of an inorganic salt.

摘要翻译： 一种用于回收干扰素的方法，其包括将含有由人源诱导的细胞产生的干扰素的溶液与水不溶性硫酸化多糖接触以允许干扰素被吸附在水不溶性硫酸化多糖上，然后选择性地洗脱干扰素 无机盐水溶液。

公开(公告)号：US4113712A

公开(公告)日：1978-09-12

申请号：US664983

申请日：1976-03-08

申请人： Satoshi Funakoshi

发明人： Satoshi Funakoshi

IPC分类号： A61K39/00 ,  C07K14/02 ,  G01N33/576 ,  G01N33/96 ,  A61K39/12 ,  A61K39/42 ,  C07G7/00 ,  G01N33/16

CPC分类号： C07K14/005 ,  G01N33/5764 ,  G01N33/96 ,  A61K39/00 ,  C12N2730/10122 ,  Y10S436/82 ,  Y10S436/826 ,  Y10S530/806 ,  Y10S530/831

摘要： Hepatitis B surface antigen particles composed of single polypeptide subunits having a molecular weight of about 55,000 dalton are prepared by heating hepatitis B surface antigen in isotonic sodium chloride solution at about neutral pH containing a surfactant capable of delipidation such as alkali-metal salts of bile acids or of lauroylsarcosinic acid, or poloxyethylene alkylphenol containing an average oxyethylene of 7 to 10 molecules, or polyoxyethylene sorbitan monoalkylester containing an average oxyethylene of 20 molecules.A uniform hepatitis B surface antigen particle thus obtained has a spherical form 18 to 22 nm in diameter with an empty core, a molecular weight of about 2,200,000 dalton, and the characteristic of low toxicity.This hepatitis B surface antigen particle is useful for the preparation of vaccines, as a standard antigen reagent for testing hepatitis B surface antigen and the antibody, and as an antigen for immunizing animals to obtain a highly specific and strong antibody.

摘要翻译： 由分子量约55,000道尔顿的单个多肽亚单位组成的乙型肝炎表面抗原颗粒是通过在含有能够脱脂的表面活性剂的等渗氯化钠溶液中加热乙肝表面抗原来制备的，所述表面活性剂含有能够脱脂的表面活性剂，例如胆汁酸的碱金属盐 或月桂酰肌氨酸或含有7〜10分子的平均氧化乙烯的聚氧乙烯烷基苯酚，或含有20分子的平均氧化乙烯的聚氧乙烯山梨糖醇酐单烷基酯。

公开(公告)号：US4701325A

公开(公告)日：1987-10-20

申请号：US580183

申请日：1984-02-15

申请人： Yasuo Ueda ,  Yoshio Kagitani ,  Shirou Komeda ,  Satoshi Funakoshi

发明人： Yasuo Ueda ,  Yoshio Kagitani ,  Shirou Komeda ,  Satoshi Funakoshi

IPC分类号： A61K33/04 ,  A61P43/00 ,  A61K31/55

CPC分类号： A61K33/04

摘要： An alkali metal hydrogensulfite or sulfite is effective for controlling a local injury such as inflammation and vein injury occurring on the injection of an antitumor benzodiazepine compound of the formula ##STR1## wherein R.sub.1 denotes hydrogen atom, or acyl, carbamyl, or alkoxycarbonyl group; R.sub.2 denotes hydrogen atom or acyl group; and R.sub.3 denotes sulfinic acid rest, SO.sub.2 X, or sulfonic acid rest, SO.sub.3 X, X meaning hydrogen, alkali metal or alkaline earth metal. An aqueous solution containing the both can be administered by injection.

摘要翻译： 碱式金属亚硫酸氢盐或亚硫酸盐可有效地控制局部损伤，例如在注射式IMA IMA的抗肿瘤苯并二氮杂化合物时发生的炎症和静脉损伤，其中R1表示氢原子，或酰基，氨基甲酰基或烷氧基羰基; R2表示氢原子或酰基; R3表示亚硫酸基，SO2X或磺酸基，SO3X，X表示氢，碱金属或碱土金属。 可以通过注射施用含有这两者的水溶液。

公开(公告)号：US4624927A

公开(公告)日：1986-11-25

申请号：US600740

申请日：1984-04-16

申请人： Tsunekazu Fukushima ,  Mitsugu Fujii ,  Satoshi Funakoshi ,  Tadakazu Suyama

发明人： Tsunekazu Fukushima ,  Mitsugu Fujii ,  Satoshi Funakoshi ,  Tadakazu Suyama

IPC分类号： G01N33/53 ,  C12Q1/56 ,  G01N33/86 ,  G01N31/00 ,  G01N33/556

CPC分类号： G01N33/86 ,  G01N2333/9108 ,  G01N2333/91085 ,  Y10S436/808 ,  Y10T436/106664

摘要： A reagent for determination of human blood coagulation factor XIII for reversed passive hemagglutination reaction which comprises sensitized erythrocytes prepared by sensitizing animal erythrocytes with specific anti-human factor XIII antibody, and a kit using the reagent are disclosed.

摘要翻译： 公开了一种用于测定用于反向被动血凝反应的人血液凝固因子XIII的试剂，其包括通过用特异性抗人因子XIII抗体对动物红细胞进行敏化制备的致敏红细胞和使用该试剂的试剂盒。