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公开(公告)号：US07368072B2
公开(公告)日：2008-05-06
申请号：US10315656
申请日：2002-12-10
CPC分类号： B29D11/00048 , B29D11/00317 , B29D11/00653
摘要： Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a casting mold containing a polymerizable monomer that can be at least partially cured before and/or after the addition. Another method involves providing an amount of polymerizable photochromic monomer for the pupillary region and an amount of polymerizable non-photochromic monomer for the remainder of the contact lens in a casting mold. The photochromic and non-photochromic monomers can differ by their degree of polymerization, viscosity and/or density.
摘要翻译： 描述了在透镜的中心或瞳孔区域内具有光致变色材料的隐形眼镜及其制造方法。 在一种方法中，将光致变色量的至少一种光致变色材料添加到含有可聚合单体的铸模的瞳孔区域中，该可聚合单体可以在添加之前和/或之后至少部分固化。 另一种方法包括提供一定量的用于瞳孔区域的可聚合光致变色单体和一定量的用于在模具中的隐形眼镜的其余部分的可聚合的非光致变色单体。 光致变色和非光致变色单体可以通过其聚合度，粘度和/或密度而不同。
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公开(公告)号：US20120145973A1
公开(公告)日：2012-06-14
申请号：US13314297
申请日：2011-12-08
申请人： Kevin E. Bancroft , Anu Chopra , Xiao-Man Dai , Beon-Kyu Kim , David B. Knowles , Jason R. Lewis , Victor A. Montes , Stephen D. Straight , Massimiliano Tomasulo , Barry Van Gemert , Robert W. Walters , Wenjing Xiao , Huayun Yu , Elizabeth A. Zezinka
发明人： Kevin E. Bancroft , Anu Chopra , Xiao-Man Dai , Beon-Kyu Kim , David B. Knowles , Jason R. Lewis , Victor A. Montes , Stephen D. Straight , Massimiliano Tomasulo , Barry Van Gemert , Robert W. Walters , Wenjing Xiao , Huayun Yu , Elizabeth A. Zezinka
IPC分类号： G02B5/23 , C07D413/10 , C07D405/10 , C07D311/78
CPC分类号： C07D405/04 , C07D311/78 , C07D311/94 , C07D405/10 , C07D407/12 , C07D409/04 , C07D493/04 , C07D495/04 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1022 , C09K2211/1033 , C09K2211/1059 , C09K2211/1088 , G02B5/23 , G03C1/685 , G03C1/73 , Y10T428/31504
摘要： The present invention relates to photochromic materials that include one or more indeno-fused naphthopyrans that have particular groups at the 7, 11, and 13 positions thereof, and at the position alpha to the oxygen of the pyran ring thereof. With some embodiments, hydrogen or an alkoxy group is bonded to the 7 position, an optionally substituted phenyl is bonded to the 11 position, two alkyl groups are bonded to the 13 position, and two optionally substituted phenyl groups are bonded to the position alpha to the oxygen of the pyran ring of the indeno-fused naphthopyran compound. The 13 position of the indeno-fused naphthopyrans is free of ether groups in which an ether oxygen is bonded to the 13 position, and hydroxyl. The present invention also relates to photochromic articles and compositions that include such indeno-fused naphthopyrans.
摘要翻译： 本发明涉及光致变色材料，其包括一种或多种茚并稠合的萘并吡喃，其在其7,11和13位具有特定基团，并且在其吡喃环的氧的位置。 在一些实施方案中，氢或烷氧基键合至7位，任选取代的苯基键合至11位，两个烷基键合至13位，并且两个任选取代的苯基键合至位置α 茚并稠合萘并吡喃化合物的吡喃环的氧。 茚并稠合萘并吡喃的13位没有醚基，其中醚氧与13位结合，羟基。 本发明还涉及包含这种茚并稠合萘并吡喃的光致变色制品和组合物。
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公开(公告)号：US07560056B2
公开(公告)日：2009-07-14
申请号：US12027522
申请日：2008-02-07
CPC分类号： B29D11/00048 , B29D11/00317 , B29D11/00653
摘要： Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a casting mold containing a polymerizable monomer that can be at least partially cured before and/or after the addition. Another method involves providing an amount of polymerizable photochromic monomer for the pupillary region and an amount of polymerizable non-photochromic monomer for the remainder of the contact lens in a casting mold. The photochromic and non-photochromic monomers can differ by their degree of polymerization, viscosity and/or density.
摘要翻译： 描述了在透镜的中心或瞳孔区域内具有光致变色材料的隐形眼镜及其制造方法。 在一种方法中，将光致变色量的至少一种光致变色材料添加到含有可聚合单体的铸模的瞳孔区域中，该可聚合单体可以在添加之前和/或之后至少部分固化。 另一种方法包括提供一定量的用于瞳孔区域的可聚合光致变色单体和一定量的用于在模具中的隐形眼镜的其余部分的可聚合的非光致变色单体。 光致变色和非光致变色单体可以通过其聚合度，粘度和/或密度而不同。
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公开(公告)号：US20080125512A1
公开(公告)日：2008-05-29
申请号：US12027522
申请日：2008-02-07
CPC分类号： B29D11/00048 , B29D11/00317 , B29D11/00653
摘要： Described are contact lenses having photochromic materials within the central or pupillary area of the lens and methods for manufacturing such lenses. In one method, a photochromic amount of at least one photochromic material is added to the pupillary region of a casting mold containing a polymerizable monomer that can be at least partially cured before and/or after the addition. Another method involves providing an amount of polymerizable photochromic monomer for the pupillary region and an amount of polymerizable non-photochromic monomer for the remainder of the contact lens in a casting mold. The photochromic and non-photochromic monomers can differ by their degree of polymerization, viscosity and/or density.
摘要翻译： 描述了在透镜的中心或瞳孔区域内具有光致变色材料的隐形眼镜及其制造方法。 在一种方法中，将光致变色量的至少一种光致变色材料添加到含有可聚合单体的铸模的瞳孔区域中，该可聚合单体可以在添加之前和/或之后至少部分固化。 另一种方法包括提供一定量的用于瞳孔区域的可聚合光致变色单体和一定量的用于在模具中的隐形眼镜的其余部分的可聚合的非光致变色单体。 光致变色和非光致变色单体可以通过其聚合度，粘度和/或密度而不同。
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公开(公告)号：US06555028B2
公开(公告)日：2003-04-29
申请号：US09828260
申请日：2001-04-06
IPC分类号： G02B523
CPC分类号： C07D407/12 , C07D311/92 , C07D311/94 , C07D311/96 , C08G65/3315 , C08G65/3318 , C08G65/3346 , C08K5/1545 , C09B57/00 , C09B57/02 , C09B69/109 , C09K9/02 , G02B1/041 , G02B1/043 , G02B5/23
摘要： Described are polymeric matrix compatibilized naphthopyran compounds, examples of which are certain 2H-naphtho[1,2-b]pyrans, 3H-naphtho[2,1-b]pyrans and indeno[2,1-f]naphtho[1,2-b]pyrans each having at least one substituent containing terminal and/or pendant groups selected from hydroxyl, carboxyl, sulfo, sulfono, (meth)acryloxy, 2-(methacryloxy)ethylcarbamyl, epoxy or a mixture thereof. Specific substituents are also present on the naphtho, indeno and/or pyrano portions of the compounds. These compounds may be represented by the following graphic formulae: Also described are various substrates that contain or that are coated with such compounds. Optically clear articles such as contact lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, are also described.
摘要翻译： 描述的是聚合物基质相容的萘并吡喃化合物，其实例是一定的2H-萘并[1,2-b]吡喃，3H-萘并[2,1-b]吡喃和茚并[2,1-f]萘并[1,2 （甲基丙烯酰氧基）乙基氨基甲酰基，环氧基或它们的混合物中的至少一个含有末端和/或侧基的取代基的-b]吡喃各自具有选自羟基，羧基，磺基，磺基，（甲基）丙烯酰氧基， 具体的取代基也存在于化合物的萘酚，茚并和/或吡喃葡萄糖部分上。 这些化合物可以由以下图形表示：还描述了含有这些化合物或者被这些化合物包被的各种底物。 还描述了光学清洁的物品，例如隐形眼镜或其它掺入新型萘并吡喃化合物或其组合与互补光致变色化合物的塑料透明胶片。
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公开(公告)号：US09028728B2
公开(公告)日：2015-05-12
申请号：US13314297
申请日：2011-12-08
申请人： Kevin E. Bancroft , Anu Chopra , Xiao-Man Dai , Beon-Kyu Kim , David B. Knowles , Jason R. Lewis , Victor A. Montes , Stephen D. Straight , Massimiliano Tomasulo , Barry Van Gemert , Robert W. Walters , Wenjing Xiao , Huayun Yu , Elizabeth A. Zezinka
发明人： Kevin E. Bancroft , Anu Chopra , Xiao-Man Dai , Beon-Kyu Kim , David B. Knowles , Jason R. Lewis , Victor A. Montes , Stephen D. Straight , Massimiliano Tomasulo , Barry Van Gemert , Robert W. Walters , Wenjing Xiao , Huayun Yu , Elizabeth A. Zezinka
IPC分类号： G02B5/23 , C07D405/04 , C07D405/10 , C07D407/12 , C07D409/04 , C07D493/04 , C07D495/04 , C09K9/02 , G03C1/73 , C07D311/78 , C07D311/94 , G03C1/00 , G03C1/685
CPC分类号： C07D405/04 , C07D311/78 , C07D311/94 , C07D405/10 , C07D407/12 , C07D409/04 , C07D493/04 , C07D495/04 , C09K9/02 , C09K2211/1007 , C09K2211/1011 , C09K2211/1022 , C09K2211/1033 , C09K2211/1059 , C09K2211/1088 , G02B5/23 , G03C1/685 , G03C1/73 , Y10T428/31504
摘要： The present invention relates to photochromic materials that include one or more indeno-fused naphthopyrans that have particular groups at the 7, 11, and 13 positions thereof, and at the position alpha to the oxygen of the pyran ring thereof. With some embodiments, hydrogen or an alkoxy group is bonded to the 7 position, an optionally substituted phenyl is bonded to the 11 position, two alkyl groups are bonded to the 13 position, and two optionally substituted phenyl groups are bonded to the position alpha to the oxygen of the pyran ring of the indeno-fused naphthopyran compound. The 13 position of the indeno-fused naphthopyrans is free of ether groups in which an ether oxygen is bonded to the 13 position, and hydroxyl. The present invention also relates to photochromic articles and compositions that include such indeno-fused naphthopyrans.
摘要翻译： 本发明涉及光致变色材料，其包括一种或多种茚并稠合的萘并吡喃，其在其7,11和13位具有特定基团，并且在其吡喃环的氧的位置。 在一些实施方案中，氢或烷氧基键合至7位，任选取代的苯基键合至11位，两个烷基键合至13位，并且两个任选取代的苯基键合至位置α 茚并稠合萘并吡喃化合物的吡喃环的氧。 茚并稠合萘并吡喃的13位没有醚基，其中醚氧与13位结合，羟基。 本发明还涉及包含这种茚并稠合萘并吡喃的光致变色制品和组合物。
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7.发明授权Photochromic articles that activate behind ultraviolet radiation blocking transparencies and methods for preparation 有权激活后紫外线阻挡透明胶片的光致变色制品及其制备方法公开(公告)号：US07166357B2
公开(公告)日：2007-01-23
申请号：US10393179
申请日：2003-03-20
申请人： Anil Kumar , Michael S. Misura , Robert W. Walters , Barry Van Gemert , Anu Chopra , Clara E. Nelson
发明人： Anil Kumar , Michael S. Misura , Robert W. Walters , Barry Van Gemert , Anu Chopra , Clara E. Nelson
CPC分类号： C07D498/10 , C09K9/02 , C09K2211/1011 , C09K2211/1033 , C09K2211/1088 , Y10T428/31504 , Y10T428/31507 , Y10T428/31511 , Y10T428/31551 , Y10T428/31678 , Y10T428/31786 , Y10T428/31855 , Y10T428/31935 , Y10T428/31975 , Y10T428/31989 , Y10T428/31993
摘要： Described are photochromic articles that include a substrate and a photochromic amount of at least one organic photochromic material (b) represented by graphic formula XIII adapted to change from an unactivated state to an activated state by exposure to radiation substantially in a wavelength range from 380 to 410 nanometers (nm) when measured over a wavelength range of from 380 to 700 nm. The photochromic articles demonstrate a photochromic response when activated behind an ultraviolet blocking transparency such as an automotive windshield. For example, the photochromic articles retain at least 12 percent of the activation measured as change in optical density or delta OD under outdoor simulating conditions in the Outdoor Test when tested under conditions simulating an eyeglass wearer behind an automotive windshield in the Behind the Windshield Test. Methods for producing the aforedescribed photochromic articles are also described.
摘要翻译： 描述的是光致变色制品，其包括基底和光致变色量的由图形式XIII表示的至少一种有机光致变色材料（b），其适于通过暴露于基本上在380至 - 的波长范围内的辐射而从未激活状态改变为活化状态 在380至700nm的波长范围内测量时为410纳米（nm）。 当紫外线阻挡透明体（例如汽车挡风玻璃）被激活时，光致变色制品表现出光致变色响应。 例如，当在模拟在挡风玻璃测试后面的汽车挡风玻璃后面的眼镜佩戴者的条件下进行测试时，光致变色制品保持至少12％的活化作为室外模拟条件下的光密度或ΔOD的变化测量。 还描述了制备上述光致变色制品的方法。
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公开(公告)号：US08067100B2
公开(公告)日：2011-11-29
申请号：US12240584
申请日：2008-09-29
CPC分类号： C09K11/06 , C07F15/002 , C09K2211/1014 , C09K2211/1029 , C09K2211/185 , H05B33/14 , Y10S428/917
摘要： The present invention relates to organic light emitting devices (OLEDs), and more specifically to phosphorescent organic materials used in such devices. More specifically, the present invention relates to emissive phosphorescent material which comprise at least one tridentate ligand bound to a metal center, wherein at least one of the bonds to the tridentate ligand is a carbon-metal bond.
摘要翻译： 本发明涉及有机发光器件（OLED），更具体地涉及用于这种器件中的磷光有机材料。 更具体地说，本发明涉及包含与金属中心结合的至少一个三齿配体的发射磷光材料，其中至少一个与三齿配体的键是碳 - 金属键。
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![Metal complexes of cyclometallated imidazo[1,2-f]phenanthridine and diimidazo[1,2-a:1′,2′-c]quinazoline ligands and isoelectronic and benzannulated analogs thereof](/abs-image/US/2011/03/29/US07915415B2/abs.jpg.150x150.jpg)
9.发明授权Metal complexes of cyclometallated imidazo[1,2-f]phenanthridine and diimidazo[1,2-a:1′,2′-c]quinazoline ligands and isoelectronic and benzannulated analogs thereof 有权环金属咪唑并[1,2-f]菲啶和二咪唑并[1,2-a：1'，2'-c]喹唑啉配体及其等电子和苯并对映体的金属络合物公开(公告)号：US07915415B2
公开(公告)日：2011-03-29
申请号：US11704585
申请日：2007-02-09
申请人： David B. Knowles , Chun Lin , Peter Borden MacKenzie , Jui-Yi Tsai , Robert W. Walters , Scott A. Beers , Cory S. Brown , Walter H. Yeager
发明人： David B. Knowles , Chun Lin , Peter Borden MacKenzie , Jui-Yi Tsai , Robert W. Walters , Scott A. Beers , Cory S. Brown , Walter H. Yeager
CPC分类号： H01L51/0085 , C07F15/0033 , C07F15/0086 , C09B57/00 , C09K11/06 , C09K2211/1007 , C09K2211/1029 , C09K2211/1033 , C09K2211/1037 , C09K2211/1044 , C09K2211/1048 , C09K2211/1051 , C09K2211/1055 , C09K2211/1059 , C09K2211/1062 , C09K2211/1066 , C09K2211/1074 , C09K2211/1081 , C09K2211/1088 , C09K2211/1092 , C09K2211/185 , H01L51/0087 , H01L51/0094 , H01L51/5012 , H01L51/5016 , H01L2251/5353 , H05B33/14
摘要： Compounds comprising phosphorescent metal complexes comprising cyclometallated imidazo[1,2-f]phenanthridine and diimidazo[1,2-a:1′,2′-c]quinazoline ligands, or isoelectronic or benzannulated analogs thereof, are described. Organic light emitting diode devices comprising these compounds are also described.
摘要翻译： 描述了包含环金属化的咪唑并[1,2-f]菲啶和二咪唑并[1,2-a：1'，2'-c]喹唑啉配体的磷光金属络合物或其等电子或苯并对映体的化合物。 还描述了包含这些化合物的有机发光二极管器件。
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公开(公告)号：US20110071198A1
公开(公告)日：2011-03-24
申请号：US12736966
申请日：2009-05-27
申请人： Robert J. Lefkowitz , Scott M. Dewire , Erin J. Whalen , Jonathan D. Violin , Robert W. Walters
发明人： Robert J. Lefkowitz , Scott M. Dewire , Erin J. Whalen , Jonathan D. Violin , Robert W. Walters
IPC分类号： A61K31/455 , G01N33/53 , A61P9/10 , A61P3/06
CPC分类号： G01N33/566 , C07K14/705 , G01N2333/726 , G01N2800/044
摘要： The present invention relates, in general, to nicotinic acid receptor ligands and, in particular, to ligands that have a relative efficacy for activating a G-protein-coupled receptor function (e.g., signaling) that is greater than their relative efficacy for stimulating β-arrestin function (e.g., recruitment and/or signaling). The invention further relates to the use of such “biased ligands” to decrease triglycerides levels and to potentially increase high density lipoprotein (HDL) levels in patients and potentially lower low density lipoprotein (LDL) and/or very low density lipoprotein (VLDL) levels. In addition, the invention relates to methods of identifying such “biased ligands”.
摘要翻译： 本发明一般涉及烟酸受体配体，特别是涉及具有激活G蛋白偶联受体功能（例如，信号传导）的相对功效的配体，其大于它们对刺激作用的相对功效 ; -arrestin功能（例如招聘和/或信令）。 本发明还涉及这种“有偏配体”降低甘油三酯水平并潜在地增加患者中高密度脂蛋白（HDL）水平以及潜在地降低低密度脂蛋白（LDL）和/或极低密度脂蛋白（VLDL）水平的用途 。 此外，本发明涉及鉴定这种“有偏配体”的方法。
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