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1.发明授权
公开(公告)号：US5723599A
公开(公告)日：1998-03-03
申请号：US409902
申请日：1995-03-22
申请人： Robert E. Klem , Timothy A. Riley
发明人： Robert E. Klem , Timothy A. Riley
IPC分类号： C07H21/04 , C07H21/00 , C08F8/00 , C08F20/18 , C08F20/26 , C08F20/28 , C08F220/10 , C08F18/00
摘要： Polymeric reagents useful in the solid phase synthesis of oligomers are provided. These polymeric reagents are suitably loaded with nucleosidyl moieties and do not undergo non-specific chain elongation.
摘要翻译： 提供了可用于低聚物固相合成的聚合物试剂。 这些聚合物试剂适当地加载有核苷基部分并且不经历非特异性链延长。
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2.发明授权Process for the synthesis of oligonucleotides and analogs with low water oxidation step 失效用于低水氧化步骤合成寡核苷酸和类似物的方法
公开(公告)号：US5726300A
公开(公告)日：1998-03-10
申请号：US260392
申请日：1994-06-15
CPC分类号： C07H21/00
摘要： Methods of synthesizing oligomers using low water oxidizer reagents which result in high coupling efficiencies are provided. These methods are suitable for larger scale preparations of methylphosphonate oligomers.
摘要翻译： 提供了使用低水氧化剂试剂合成寡聚物的方法，其导致高耦合效率。 这些方法适用于甲基膦酸酯低聚物的较大规模制备。
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3.发明申请METHOD FOR DETERMINING RECURRENCE OR STABLE DISEASE AFTER TREATMENT FOR PROSTATE CANCER 审中-公开治疗前列腺癌后确定复发或稳定疾病的方法公开(公告)号：US20130323739A1
公开(公告)日：2013-12-05
申请号：US13844639
申请日：2013-03-15
申请人： Robert E. Klem , Jonathan E. McDermed , Russ Saunders , Edward Jablonski , Thomas Adams , Mark J. Samo
发明人： Robert E. Klem , Jonathan E. McDermed , Russ Saunders , Edward Jablonski , Thomas Adams , Mark J. Samo
CPC分类号： G01N33/5091 , G01N33/57434 , G01N33/689 , G01N2800/54 , G01N2800/56
摘要： This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have prostate cancer recurrence or stable disease.
摘要翻译： 本发明描述了用于具有低功能敏感性的PSA测定中的组合物和方法，其可用于例如在治疗后检测前列腺疾病的早期复发以及确定患者是否患有前列腺癌复发或稳定疾病。
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公开(公告)号：US20080167263A1
公开(公告)日：2008-07-10
申请号：US11963242
申请日：2007-12-21
CPC分类号： C07K16/1063 , A61K31/136 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K39/39558 , A61K39/39575 , A61K2039/505 , C07K16/32 , C07K2317/34 , C12N9/0002 , A61K2300/00
摘要： Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders. Also provided are methods for modulating the efficacy of nucleic acid based therapeutics.
摘要翻译： 本文公开了共价反应性抗原类似物。 本发明的抗原可用于刺激对与特定医学病症相关的预定抗原特异性的催化抗体的产生。 抗原类似物也可用于永久灭活在某些自身免疫性疾病以及某些淋巴组织增生性疾病中产生的内源性产生的催化抗体。 还提供了用于调节基于核酸的治疗剂的功效的方法。
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5.发明授权Tri(alkylcarboxylato)gallium (III) products and pharmaceutical compositions containing them 失效三（烷基羧基）镓（III）产品和含有它们的药物组合物公开(公告)号：US07119217B2
公开(公告)日：2006-10-10
申请号：US10668473
申请日：2003-09-22
CPC分类号： C07C51/412 , C07C53/126 , C07F5/003
摘要： Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
摘要翻译： 提供了新颖的三（烷基羧基）镓（III）化合物，其例子是三异氰酸镓（III），其制备方法，含有它们的药物组合物和使用该药物组合物的方法。
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6.发明申请METHOD FOR DETERMINING LIKELIHOOD OF CLINICAL RECURRENCE OR CLINICALLY STABLE DISEASE OF PROSTATE CANCER AFTER RADICAL PROSTATECTOMY 审中-公开确定临床复发的临床症状或放射性前列腺癌临床稳定性疾病的方法公开(公告)号：US20120329713A1
公开(公告)日：2012-12-27
申请号：US13489430
申请日：2012-06-05
申请人： Robert E. Klem , Russell Saunders , Edward Jablonski , Thomas H. Adams , Mark J. Sarno , Jonathan E. McDermed
发明人： Robert E. Klem , Russell Saunders , Edward Jablonski , Thomas H. Adams , Mark J. Sarno , Jonathan E. McDermed
CPC分类号： G01N33/57434 , C07K16/3069 , G01N33/57488 , G01N2333/96455 , G01N2800/54
摘要： This invention describes compositions and methods for use in PSA assays having low functional sensitivity which are useful, for example, in the detection of early stage recurrence of prostate disease following treatment and in the determination of whether patients have early stage biochemical reoccurrence (ES-BCR) or stable disease.
摘要翻译： 本发明描述了用于具有低功能敏感性的PSA测定中的组合物和方法，其可用于例如在治疗后检测前列腺疾病的早期复发和确定患者是否具有早期生化复发（ES-BCR ）或疾病稳定。
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公开(公告)号：US20100144840A1
公开(公告)日：2010-06-10
申请号：US12636452
申请日：2009-12-11
IPC分类号： A61K31/7088 , A61K31/713
CPC分类号： C07K16/1063 , A61K31/136 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K39/39558 , A61K39/39575 , A61K2039/505 , C07K16/32 , C07K2317/34 , C12N9/0002 , A61K2300/00
摘要： Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders. Also provided are methods for modulating the efficacy of nucleic acid based therapeutics.
摘要翻译： 本文公开了共价反应性抗原类似物。 本发明的抗原可用于刺激对与特定医学病症相关的预定抗原特异性的催化抗体的产生。 抗原类似物也可用于永久灭活在某些自身免疫性疾病以及某些淋巴组织增生性疾病中产生的内源性产生的催化抗体。 还提供了用于调节基于核酸的治疗剂的功效的方法。
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公开(公告)号：US07960364B2
公开(公告)日：2011-06-14
申请号：US12636452
申请日：2009-12-11
CPC分类号： C07K16/1063 , A61K31/136 , A61K31/70 , A61K31/7088 , A61K31/713 , A61K39/39558 , A61K39/39575 , A61K2039/505 , C07K16/32 , C07K2317/34 , C12N9/0002 , A61K2300/00
摘要： Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens associated with particular medical disorders. The antigen analogs may also be used to permanently inactivate endogenously produced catalytic antibodies produced in certain autoimmune diseases as well as in certain lymphoproliferative disorders. Also provided are methods for modulating the efficacy of nucleic acid based therapeutics.
摘要翻译： 本文公开了共价反应性抗原类似物。 本发明的抗原可用于刺激对与特定医学病症相关的预定抗原特异性的催化抗体的产生。 抗原类似物也可用于永久灭活在某些自身免疫性疾病以及某些淋巴组织增生性疾病中产生的内源性产生的催化抗体。 还提供了用于调节基于核酸的治疗剂的功效的方法。
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公开(公告)号：US5424440A
公开(公告)日：1995-06-13
申请号：US158167
申请日：1993-11-24
申请人： Robert E. Klem , William Marvin
发明人： Robert E. Klem , William Marvin
IPC分类号： G01N33/50 , C07D277/64 , C07D277/68 , C07F9/6541 , C09K11/07 , C12Q1/34 , C12Q1/42 , C12Q1/44 , C12Q1/68 , G01N21/78 , G01N21/80 , G01N31/22 , G01N33/533 , G01N33/58
CPC分类号： C07D277/68 , C07D277/64 , C07F9/6541 , C12Q1/34 , C12Q1/42 , G01N31/22 , G01N31/221 , G01N33/582 , C12Q2334/00
摘要： Novel benzothiazole derivatives having a fluorescence inhibiting group linked by an enzyme cleavable bond and methods for their synthesis are provided. Upon cleavage of the enzyme-cleavable bond, a strongly fluorescent reaction product is produced. These compounds may be used to detect enzymatic activity. The fluorescent reaction products are detectable at an attomolar level using a fluorometer.
摘要翻译： 提供了具有通过酶切割键连接的荧光抑制基团的新型苯并噻唑衍生物及其合成方法。 在裂解酶切割键时，产生强荧光反应产物。 这些化合物可用于检测酶活性。 荧光反应产物可以在使用荧光计的attomolar水平下检测。
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公开(公告)号：US4066673A
公开(公告)日：1978-01-03
申请号：US445067
申请日：1974-02-25
申请人： Joseph B. Doughty , Robert E. Klem
发明人： Joseph B. Doughty , Robert E. Klem
IPC分类号： C07D303/36 , C07D301/24 , C07D301/00
CPC分类号： C07D303/36
摘要： The preparation of a 1,2-epoxy propyl trialkylamine chloride in a methanol solution is disclosed. The products are useful for preparing cationic ethers in both aqueous and organic solvent solutions free of inorganic alkalis or salts.
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