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1.发明授权Tri(alkylcarboxylato)gallium (III) products and pharmaceutical compositions containing them 失效三（烷基羧基）镓（III）产品和含有它们的药物组合物公开(公告)号：US07119217B2
公开(公告)日：2006-10-10
申请号：US10668473
申请日：2003-09-22
CPC分类号： C07C51/412 , C07C53/126 , C07F5/003
摘要： Provided are novel tri(alkylcarboxylato) gallium (III) compounds, exemplified by tripalmitato gallium (III), methods for making them, pharmaceutical compositions containing them, and methods of using the pharmaceutical compositions.
摘要翻译： 提供了新颖的三（烷基羧基）镓（III）化合物，其例子是三异氰酸镓（III），其制备方法，含有它们的药物组合物和使用该药物组合物的方法。
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公开(公告)号：US06982096B2
公开(公告)日：2006-01-03
申请号：US10759290
申请日：2004-01-16
IPC分类号： A61K33/36
CPC分类号： A61K31/53 , A61K31/285 , A61K31/555 , A61K33/24 , A61K33/36 , A61K41/00 , A61K2300/00
摘要： The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
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公开(公告)号：US4686104A
公开(公告)日：1987-08-11
申请号：US853144
申请日：1986-04-22
摘要： Metal-containing compounds have been found to decrease calcium resorption from bone. These compounds, when administered to patients who are suffering from diseases characterized by accelerated bone resorption, impede the flow of bone calcium into the blood and increase the calcium content of bone tissue.
摘要翻译： 已经发现含金属化合物降低了骨吸收钙。 这些化合物在给予患有以加速骨吸收为特征的疾病的患者时，阻止骨钙进入血液并增加骨组织的钙含量。
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公开(公告)号：US20170197923A1
公开(公告)日：2017-07-13
申请号：US15118243
申请日：2015-01-22
IPC分类号： C07D239/557 , C07D417/12 , C07D401/12 , C07D239/60 , C07D413/04 , C07D413/12 , C07D403/12
CPC分类号： C07D239/557 , A61K45/06 , C07D239/60 , C07D239/62 , C07D239/66 , C07D401/12 , C07D403/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D487/04
摘要： Bifunctional compounds that increase uric acid excretion and reduce uric acid production. Methods of using these compounds for reducing uric acid levels in blood or serum, for treating disorders or uric acid metabolism, and for maintaining normal uric acid levels in blood or serum are provided. Pharmaceutical compositions comprising the bifunctional compounds are also provided.
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5.发明申请PROCESS FOR PRODUCING ARSENIC TRIOXIDE FORMULATIONS AND METHODS FOR TREATING CANCER USING ARSENIC TRIOXIDE OR MELARSOPROL 有权生产三氧化二砷配方的方法和使用三氧化二砷或麦芽糖治疗癌症的方法公开(公告)号：US20110091573A1
公开(公告)日：2011-04-21
申请号：US12974076
申请日：2010-12-21
CPC分类号： A61K31/53 , A61K31/285 , A61K31/555 , A61K33/24 , A61K33/36 , A61K41/00 , A61K2300/00
摘要： The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
摘要翻译： 本发明涉及砷化合物用于治疗多种白血病，淋巴瘤和实体瘤的用途。 此外，砷化合物可以与其它治疗剂如类视黄醇组合使用。 本发明还提供了一种生产三氧化二砷制剂的方法。
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公开(公告)号：US06861076B2
公开(公告)日：2005-03-01
申请号：US10758994
申请日：2004-01-16
IPC分类号： A61K31/203 , A61K31/285 , A61K31/53 , A61K31/555 , A61K33/24 , A61K33/36 , A61P35/00 , A61P35/02
CPC分类号： A61K31/53 , A61K31/285 , A61K31/555 , A61K33/24 , A61K33/36 , A61K41/00 , A61K2300/00
摘要： The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
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公开(公告)号：US06723351B2
公开(公告)日：2004-04-20
申请号：US10425785
申请日：2003-04-30
IPC分类号： A61K3336
CPC分类号： A61K31/53 , A61K31/285 , A61K31/555 , A61K33/24 , A61K33/36 , A61K41/00 , A61K2300/00
摘要： The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
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公开(公告)号：US06515022B2
公开(公告)日：2003-02-04
申请号：US09854331
申请日：2001-05-11
IPC分类号： A61K3120
CPC分类号： A61K9/008 , A61K31/07 , A61K31/167 , A61K31/192 , A61K31/203 , A61K47/18
摘要： Administration of retinoids by inhalation is used to overcome the chronic toxicity problems presented by systemic administration and to make retinoid therapy available as an option for the treatment of fibrotic lung disease, emphysema, and the prevention and treatment of epithelial cancers of the respiratory tract, especially those that are associated with tobacco use. Retinoids are administered by inhalation to the respiratory tract of the individual as an air-borne composition with a metered dose aerosol-producing inhaler, in which the retinoid is dissolved in a combination of a pharmaceutically acceptable chlorofluorocarbon propellant and an alkylamine solubilizing agent.
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9.发明授权Process for producing arsenic trioxide formulations and methods for treating cancer using arsenic trioxide or melarsoprol 有权三氧化二砷制剂的制备方法以及使用三氧化二砷或梅三酚治疗癌症的方法公开(公告)号：US08273379B2
公开(公告)日：2012-09-25
申请号：US12974076
申请日：2010-12-21
IPC分类号： A61K33/36
CPC分类号： A61K31/53 , A61K31/285 , A61K31/555 , A61K33/24 , A61K33/36 , A61K41/00 , A61K2300/00
摘要： The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
摘要翻译： 本发明涉及砷化合物用于治疗多种白血病，淋巴瘤和实体瘤的用途。 此外，砷化合物可以与其它治疗剂如类视黄醇组合使用。 本发明还提供了一种生产三氧化二砷制剂的方法。
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公开(公告)号：US20120004429A1
公开(公告)日：2012-01-05
申请号：US13170830
申请日：2011-06-28
IPC分类号： C07D317/70
CPC分类号： C07D493/08 , C07D205/08 , C07D305/14 , C07D401/04 , C07D407/02
摘要： The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
摘要翻译： 本发明提供了一种制备口服可用的五环紫杉烷化合物的方法，以及可用于其制备的中间体。
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