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公开(公告)号：US20120004429A1
公开(公告)日：2012-01-05
申请号：US13170830
申请日：2011-06-28
IPC分类号： C07D317/70
CPC分类号： C07D493/08 , C07D205/08 , C07D305/14 , C07D401/04 , C07D407/02
摘要： The present invention provides a method for the preparation of orally available pentacyclic taxane compounds, as well as intermediates useful in their preparation.
摘要翻译： 本发明提供了一种制备口服可用的五环紫杉烷化合物的方法，以及可用于其制备的中间体。
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公开(公告)号：US20100216867A1
公开(公告)日：2010-08-26
申请号：US12753285
申请日：2010-04-02
IPC分类号： A61K31/7088 , A61P35/00
CPC分类号： C12N15/1135 , A61K38/00 , C12N2310/315
摘要： The present invention is directed to the use of bcl-2 antisense oligomers to treat and prevent bcl-2 related disorders. These disorders include cancers, tumors, carcinomas and cell-proliferative related disorders. In one embodiment of the invention, a bcl-2 antisense oligomer is administered at high doses. The present invention is also directed to a method of preventing or treating a bcl-2 related disorder, in particular cancer, comprising administering a bcl-2 antisense oligomer for short periods of time. The present invention is further drawn to the use of bcl-2 antisense oligomers to increase the sensitivity of a subject to cancer therapeutics. The present invention also relates to pharmaceutical compositions comprising one or more bcl-2 antisense oligomers, which may comprise one or more cancer therapeutic agents.
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公开(公告)号：US20090275655A1
公开(公告)日：2009-11-05
申请号：US12431058
申请日：2009-04-28
IPC分类号： A61K31/28
CPC分类号： A61K31/28
摘要： The present invention provides novel pharmaceutical gallium compositions, as well as methods for their preparation and methods for treating conditions and diseases such as cancer, hypercalcemia, osteoporosis, osteopenia, Paget's disease, and infections.
摘要翻译： 本发明提供新颖的药物镓组合物及其制备方法以及治疗疾病如癌症，高钙血症，骨质疏松症，骨质减少症，佩吉特氏病和感染的方法。
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公开(公告)号：US20180002315A1
公开(公告)日：2018-01-04
申请号：US15545429
申请日：2016-01-20
IPC分类号： C07D403/12 , C07D413/12 , C07D239/62
CPC分类号： C07D403/12 , C07D239/62 , C07D403/10 , C07D413/10 , C07D413/12
摘要： Bifunctional compounds that increase uric acid excretion and reduce uric acid production, and monofunctional compounds that either increase uric acid excretion or reduce uric acid production. Methods of using these compounds for reducing uric acid levels in blood or serum, for treating disorders or uric acid metabolism, and for maintaining normal uric acid levels in blood or serum are provided. Pharmaceutical compositions comprising the bifunctional and monofunctional compounds are also provided.
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公开(公告)号：US20150133477A1
公开(公告)日：2015-05-14
申请号：US14078668
申请日：2013-11-13
IPC分类号： C07D239/60 , A61K31/513
CPC分类号： C07D239/60 , A61K31/513 , A61K31/515 , A61K2300/00
摘要： Methods for reducing uric acid levels in blood or serum of a subject employing metabolites of merbarone as active agents. Methods for treating or preventing disorders of uric acid metabolism are also provided. The metabolites can be formulated as pharmaceutical compositions comprising the metabolites and a pharmaceutically acceptable carrier for use in these methods.
摘要翻译： 使用merbarone的代谢物作为活性剂降低受试者血液或血清中尿酸水平的方法。 还提供了治疗或预防尿酸代谢紊乱的方法。 代谢物可以配制成包含用于这些方法的代谢物和药学上可接受的载体的药物组合物。
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公开(公告)号：US20170197923A1
公开(公告)日：2017-07-13
申请号：US15118243
申请日：2015-01-22
IPC分类号： C07D239/557 , C07D417/12 , C07D401/12 , C07D239/60 , C07D413/04 , C07D413/12 , C07D403/12
CPC分类号： C07D239/557 , A61K45/06 , C07D239/60 , C07D239/62 , C07D239/66 , C07D401/12 , C07D403/12 , C07D413/04 , C07D413/12 , C07D417/12 , C07D487/04
摘要： Bifunctional compounds that increase uric acid excretion and reduce uric acid production. Methods of using these compounds for reducing uric acid levels in blood or serum, for treating disorders or uric acid metabolism, and for maintaining normal uric acid levels in blood or serum are provided. Pharmaceutical compositions comprising the bifunctional compounds are also provided.
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7.发明申请PROCESS FOR PRODUCING ARSENIC TRIOXIDE FORMULATIONS AND METHODS FOR TREATING CANCER USING ARSENIC TRIOXIDE OR MELARSOPROL 有权生产三氧化二砷配方的方法和使用三氧化二砷或麦芽糖治疗癌症的方法公开(公告)号：US20110091573A1
公开(公告)日：2011-04-21
申请号：US12974076
申请日：2010-12-21
CPC分类号： A61K31/53 , A61K31/285 , A61K31/555 , A61K33/24 , A61K33/36 , A61K41/00 , A61K2300/00
摘要： The invention relates to the use of arsenic compounds to treat a variety of leukemia, lymphoma and solid tumors. Further, the arsenic compounds may be used in combination with other therapeutic agents, such as a retinoid. The invention also provides a process for producing arsenic trioxide formulations.
摘要翻译： 本发明涉及砷化合物用于治疗多种白血病，淋巴瘤和实体瘤的用途。 此外，砷化合物可以与其它治疗剂如类视黄醇组合使用。 本发明还提供了一种生产三氧化二砷制剂的方法。
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