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1.发明授权Process for the synthesis of oligonucleotides and analogs with low water oxidation step 失效用于低水氧化步骤合成寡核苷酸和类似物的方法
公开(公告)号：US5726300A
公开(公告)日：1998-03-10
申请号：US260392
申请日：1994-06-15
CPC分类号： C07H21/00
摘要： Methods of synthesizing oligomers using low water oxidizer reagents which result in high coupling efficiencies are provided. These methods are suitable for larger scale preparations of methylphosphonate oligomers.
摘要翻译： 提供了使用低水氧化剂试剂合成寡聚物的方法，其导致高耦合效率。 这些方法适用于甲基膦酸酯低聚物的较大规模制备。
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2.发明授权
公开(公告)号：US5723599A
公开(公告)日：1998-03-03
申请号：US409902
申请日：1995-03-22
申请人： Robert E. Klem , Timothy A. Riley
发明人： Robert E. Klem , Timothy A. Riley
IPC分类号： C07H21/04 , C07H21/00 , C08F8/00 , C08F20/18 , C08F20/26 , C08F20/28 , C08F220/10 , C08F18/00
摘要： Polymeric reagents useful in the solid phase synthesis of oligomers are provided. These polymeric reagents are suitably loaded with nucleosidyl moieties and do not undergo non-specific chain elongation.
摘要翻译： 提供了可用于低聚物固相合成的聚合物试剂。 这些聚合物试剂适当地加载有核苷基部分并且不经历非特异性链延长。
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公开(公告)号：US08173666B2
公开(公告)日：2012-05-08
申请号：US12558395
申请日：2009-09-11
IPC分类号： A61K31/485 , C07D489/02
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
摘要翻译： 本发明提供通过共价连接水溶性低聚物进行化学改性的化合物。 本发明化合物当通过多种施用途径中的任一种施用时，显示出与未附着于水溶性低聚物的化合物的特征不同的特征。
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4.发明授权Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates 有权抗病毒或抗增殖磷酸盐的代谢稳定的烷氧基烷基酯，核苷膦酸盐和核苷磷酸盐公开(公告)号：US07994143B2
公开(公告)日：2011-08-09
申请号：US12797327
申请日：2010-06-09
申请人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
发明人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
CPC分类号： C07F9/657172 , C07F9/6512 , C07F9/6552 , C07F9/65616
摘要： The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
摘要翻译： 本发明涉及膦酸盐，核苷膦酸盐或核苷磷酸盐化合物，含有它们的组合物，获得它们的方法及其在治疗各种医学病症，特别是病毒感染，癌症等中的用途。
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5.发明授权Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates 有权抗病毒或抗增殖磷酸盐的代谢稳定的烷氧基烷基酯，核苷膦酸盐和核苷磷酸盐公开(公告)号：US07749983B2
公开(公告)日：2010-07-06
申请号：US11736614
申请日：2007-04-18
申请人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
发明人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
IPC分类号： A01N57/00 , A61K31/675
CPC分类号： C07F9/657172 , C07F9/6512 , C07F9/6552 , C07F9/65616
摘要： The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
摘要翻译： 本发明涉及膦酸盐，核苷膦酸盐或核苷磷酸盐化合物，含有它们的组合物，获得它们的方法及其在治疗各种医学病症，特别是病毒感染，癌症等中的用途。
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公开(公告)号：US09433684B2
公开(公告)日：2016-09-06
申请号：US12737833
申请日：2009-08-19
申请人： Samuel P. McManus , Timothy A. Riley , Sean M. Culbertson , Antoni Kozlowski , Dennis G. Fry , Xuejun Yuan , Dawei Sheng , Vidula R. Dixit
发明人： Samuel P. McManus , Timothy A. Riley , Sean M. Culbertson , Antoni Kozlowski , Dennis G. Fry , Xuejun Yuan , Dawei Sheng , Vidula R. Dixit
IPC分类号： C12Q1/68 , C12N15/11 , A61K47/48 , C08G65/329
CPC分类号： A61K47/48215 , A61K47/549 , A61K47/60 , A61K47/61 , A61K47/64 , C08G65/329 , C08L2203/02
摘要： The present invention relates to conjugates of small-interfering nucleic acids (siNA). Compositions of siNA suited for administration to a patient are described. Methods for delivering the compositions are also described.
摘要翻译： 本发明涉及小干扰核酸（siNA）的结合物。 描述适合于给予患者的siNA的组合物。 还描述了递送组合物的方法。
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公开(公告)号：US09006219B2
公开(公告)日：2015-04-14
申请号：US12921697
申请日：2009-03-12
申请人： Timothy A. Riley , Lin Cheng
发明人： Timothy A. Riley , Lin Cheng
IPC分类号： A61K31/662 , C07F9/38 , C07F9/40 , A61P31/18 , A61K47/48
CPC分类号： A61K31/662 , A61K47/60 , C07F9/40 , C08G65/3355 , C08G2650/02 , C08G2650/04 , C08G2650/38
摘要： The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.
摘要翻译： 本发明涉及（尤其）低聚物 - 膦甲酸共轭物和相关化合物。 当通过任何多种施用途径给药时，本发明的缀合物显示出优于先前施用的未缀合的膦甲酸酯化合物的优点。
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公开(公告)号：US08440687B2
公开(公告)日：2013-05-14
申请号：US13426521
申请日：2012-03-21
IPC分类号： A61K31/485 , C07D489/08
CPC分类号： A61K31/485 , A61K31/402 , A61K31/4025 , A61K31/439 , A61K31/4468 , A61K47/10 , A61K47/60 , C07D489/02
摘要： The invention provides compounds that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from those of the compound not attached to the water-soluble oligomer.
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9.发明授权Oligonucleotide probes and primers comprising universal bases for diagnostic purposes 有权寡核苷酸探针和引物包含用于诊断目的的通用碱基公开(公告)号：US08153772B2
公开(公告)日：2012-04-10
申请号：US10375504
申请日：2003-02-25
申请人： Bob D. Brown , Timothy A. Riley
发明人： Bob D. Brown , Timothy A. Riley
CPC分类号： C07H21/04 , C07H21/00 , C12N15/1034 , C12N15/113 , C12N15/1135 , C12N15/1137 , C12N2310/12 , C12N2310/31 , C12N2310/3125 , C12N2310/313 , C12N2310/315 , C12N2310/318 , C12N2310/3181 , C12N2310/321 , C12N2310/33 , C12N2310/346 , C12N2310/351 , C12N2310/3533 , C12Q1/6883 , C12Q2600/156 , C12N2310/3521
摘要： Aspects of the invention relate to novel oligonucleotides comprising universal and generic bases for use as primers and probes, as well as, methods of using said oligonucleotides for the diagnosis of disease.
摘要翻译： 本发明的方面涉及包含用作引物和探针的通用碱基和通用碱基的新型寡核苷酸，以及使用所述寡核苷酸进行疾病诊断的方法。
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公开(公告)号：US20110105438A1
公开(公告)日：2011-05-05
申请号：US12921697
申请日：2009-03-12
申请人： Timothy A. Riley , Lin Cheng
发明人： Timothy A. Riley , Lin Cheng
IPC分类号： A61K31/662 , C07F9/38 , C07F9/40 , A61P31/18
CPC分类号： A61K31/662 , A61K47/60 , C07F9/40 , C08G65/3355 , C08G2650/02 , C08G2650/04 , C08G2650/38
摘要： The invention relates to (among other things) oligomer-foscarnet conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated foscarnet compounds.
摘要翻译： 本发明涉及（尤其）低聚物 - 膦甲酸共轭物和相关化合物。 当通过任何多种施用途径给药时，本发明的缀合物显示出优于先前施用的未缀合的膦甲酸酯化合物的优点。
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