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41 条记录 (耗时 0.056 秒)

    Apparatus and method for vasodilation
    1.
    发明授权
    Apparatus and method for vasodilation 失效
    用于血管舒张的装置和方法

    公开(公告)号：US06406486B1

    公开(公告)日：2002-06-18

    申请号：US09461996

    申请日：1999-12-15

    申请人： Ralph De La Torre ,  Kenton W. Gregory

    发明人： Ralph De La Torre ,  Kenton W. Gregory

    IPC分类号： A61B1722

    CPC分类号： A61B18/26 ,  A61B17/22012 ,  A61B17/22022 ,  A61B2017/22008

    摘要： A method and apparatus for dilating blood vessels in vasospasm through the use of high frequency wave, e.g., hydraulic or acoustic waves. The invention is suitable to treat any vasospasm, including any vasospasm intractable to medication, including cerebral vasospasm, which currently is not susceptible to any mechanical or chemical treatments. The apparatus for dilating blood vessels includes a catheter having a fluid-filled lumen, a wave generator arranged within the catheter lumen for generating a wave front that propagates through the fluid in the lumen and is transmitted from the distal end of the catheter to propagate through the fluid in the blood vessel, and an energy source connected to the wave generator to provide energy to produce the wave front.

    摘要翻译： 通过使用高频波（例如液压或声波）来扩张血管痉挛中的血管的方法和装置。 本发明适用于治疗任何血管痉挛，包括药物难治的任何血管痉挛，包括目前对机械或化学治疗不敏感的脑血管痉挛。 用于扩张血管的装置包括具有流体填充内腔的导管，布置在导管内腔内的波发生器，用于产生波前通过腔内的流体传播并从导管的远端传播以传播通过 血管中的流体和连接到波发生器的能量源以提供能量以产生波前。

    Apparatus and method for vasodilation
    3.
    发明授权
    Apparatus and method for vasodilation 失效
    用于血管舒张的装置和方法

    公开(公告)号：US5662590A

    公开(公告)日：1997-09-02

    申请号：US458488

    申请日：1995-06-02

    申请人： Ralph de la Torre ,  Kenton W. Gregory

    发明人： Ralph de la Torre ,  Kenton W. Gregory

    IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B18/00 ,  A61B18/26 ,  A61F2/82

    CPC分类号： A61B18/26 ,  A61B17/22012 ,  A61B17/22022 ,  A61B2017/22008 ,  Y10S977/905 ,  Y10S977/951

    摘要： A method and apparatus for dilating blood vessels in vasospasm through the use of high frequency wave, e.g., hydraulic or acoustic waves. The invention is suitable to treat any vasospasm, including any vasospasm intractable to medication, including cerebral vasospasm, which currently is not susceptible to any mechanical or chemical treatments. The apparatus for dilating blood vessels includes a catheter having a fluid-filled lumen, a wave generator arranged within the catheter lumen for generating a wave front that propagates through the fluid in the lumen and is transmitted from the distal end of the catheter to propagate through the fluid in the blood vessel, and an energy source connected to the wave generator to provide energy to produce the wave front.

    摘要翻译： 通过使用高频波（例如液压或声波）来扩张血管痉挛中的血管的方法和装置。 本发明适用于治疗任何血管痉挛，包括药物难治的任何血管痉挛，包括目前对机械或化学治疗不敏感的脑血管痉挛。 用于扩张血管的装置包括具有流体填充内腔的导管，布置在导管内腔内的波发生器，用于产生波前通过腔内的流体传播并从导管的远端传播以传播通过 血管中的流体和连接到波发生器的能量源以提供能量以产生波前。

    Method of producing elastin, elastin-based biomaterials and tropoelastin materials
    6.
    发明授权
    Method of producing elastin, elastin-based biomaterials and tropoelastin materials 失效
    生产弹性蛋白，弹性蛋白的生物材料和托普拉斯汀材料的方法

    公开(公告)号：US06372228B1

    公开(公告)日：2002-04-16

    申请号：US09000604

    申请日：1997-12-30

    申请人： Kenton W. Gregory

    发明人： Kenton W. Gregory

    IPC分类号： A61K900

    CPC分类号： A61F2/0063 ,  A61F2/0077 ,  A61F2/042 ,  A61F2/06 ,  A61F2/07 ,  A61F2/82 ,  A61F2/91 ,  A61K38/00 ,  A61L27/227 ,  A61L27/3683 ,  A61L27/38 ,  A61L27/50 ,  A61L31/005 ,  A61L31/047 ,  A61L31/14 ,  A61L2400/02 ,  B32B5/02 ,  B32B9/02 ,  C07K14/78

    摘要： A method is provided for producing elastin or elastin-based materials or tropoelastin materials which have a substantially reduced level of calcification. These materials are typically capable of being formed into a fused layer. The subject method comprises providing unreacted elastin or elastin-based biomaterials or tropoelastin materials, and pretreating the unreacted elastin or elastin-based biomaterials or tropoelastin materials with an aliphatic alcohol prior to reaction thereof. In this way, when the pretreated unreacted elastin or elastin-based biomaterials or tropoelastin materials is reacted subsequently, elastin or elastin-based materials or tropoelastin materials are produced which have a substantially reduced level of calcification as compared with elastin or elastin-based materials or tropoelastin materials produced from non-pretreated counterpart unreacted elastin or elastin-based biomaterials or tropoelastin materials.

    摘要翻译： 提供了一种用于生产具有显着降低的钙化水平的弹性蛋白或弹性蛋白基材料或托普拉斯汀材料的方法。 这些材料通常能够形成熔融层。 本发明方法包括提供未反应的弹性蛋白或弹性蛋白基生物材料或托普拉斯汀材料，并在其反应之前用脂族醇预处理未反应的弹性蛋白或弹性蛋白基生物材料或托普弹力素材料。 以这种方式，当预处理的未反应的弹性蛋白或弹性蛋白基生物材料或特拉斯特弹性材料随后反应时，产生与弹性蛋白或弹性蛋白基材料相比具有显着降低的钙化水平的弹性蛋白或弹性蛋白基材料或特拉斯他汀材料，或 由未预处理的对应物未反应的弹性蛋白或弹性蛋白基生物材料或托普拉斯汀材料制备的原弹药材料。

    Method of producing fused biomaterials and tissue
    7.
    发明授权
    Method of producing fused biomaterials and tissue 失效
    生产融合生物材料和组织的方法

    公开(公告)号：US6087552A

    公开(公告)日：2000-07-11

    申请号：US798425

    申请日：1997-02-07

    申请人： Kenton W. Gregory

    发明人： Kenton W. Gregory

    IPC分类号： A61F2/00 ,  A61F2/04 ,  A61F2/06 ,  A61L27/22 ,  A61L27/36 ,  A61L27/38 ,  A61L27/50 ,  A61L31/00 ,  A61L31/04 ,  A61L31/14 ,  B32B5/02 ,  B32B9/02 ,  A61B17/00 ,  A61B17/04

    CPC分类号： A61L27/3804 ,  A61F2/0063 ,  A61F2/06 ,  A61F2/07 ,  A61L27/227 ,  A61L27/3641 ,  A61L27/3691 ,  A61L27/3839 ,  A61L27/50 ,  A61L31/005 ,  A61L31/047 ,  A61L31/14 ,  B32B5/02 ,  B32B9/02 ,  A61F2/042 ,  A61F2/91 ,  A61F2002/072 ,  A61F2002/075

    摘要： It is a general object of the invention to provide a method of effecting tissue repair or replacement using a biomaterial. It is a specific object of the invention to provide a biomaterial suitable for use as a stent, for example, a vascular stent, or as a conduit replacement, as an artery, vein or a ureter replacement. The biomaterial can also be used as a stent or conduit covering or lining. The present invention relates to a method of repairing, replacing or supporting a section of a body tissue. The method comprises positioning a biomaterial at the site of the section and bonding the biomaterial to the site or to the tissue surrounding the site. The bonding is effected by contacting the biomaterial and the site, or tissue surrounding the site, at the point at which said bonding is to be effected, with an energy absorbing agent. The agent is then exposed to an amount of energy absorbable by the agent sufficient to bond the biomaterial to the site or to the tissue surrounding the site.

    摘要翻译： 本发明的一般目的是提供使用生物材料进行组织修复或置换的方法。 本发明的一个具体目的是提供一种适合用作支架的生物材料，例如血管支架，或用作导管替代物，作为动脉，静脉或输尿管替代物。 生物材料也可以用作支架或导管覆盖物或内衬。 本发明涉及修复，替换或支撑身体组织的一部分的方法。 该方法包括将生物材料定位在该部位的位置处，并将生物材料粘合到现场或围绕该部位的组织。 通过使生物材料和所述部位周围的部位，在所述接合的实施点与能量吸收剂接触来实现接合。 然后将试剂暴露于一定量的能够被该试剂吸收的能量，该能量足以将生物材料粘合到现场或围绕该部位的组织。

    Delivering laser energy
    8.
    发明授权
    Delivering laser energy 失效
    提供激光能量

    公开(公告)号：US6066130A

    公开(公告)日：2000-05-23

    申请号：US261838

    申请日：1988-10-24

    申请人： Kenton W. Gregory ,  R. Rox Anderson

    发明人： Kenton W. Gregory ,  R. Rox Anderson

    IPC分类号： A61B18/20 ,  A61B17/00 ,  A61B17/22 ,  A61B18/22 ,  A61B18/24 ,  A61B19/00 ,  A61D7/00 ,  A61F2/00 ,  G02B6/032 ,  A61N5/02

    CPC分类号： G02B6/032 ,  A61B18/24 ,  A61B18/245 ,  A61B2017/00853 ,  A61B2017/22038 ,  A61B2017/22072 ,  A61B2018/206 ,  A61B2018/2261 ,  A61B2090/3933 ,  A61F2210/0019

    摘要： A method for conducting laser energy to a site includes steps of bringing the proximal end of a flexible tube near the site, filling at least a proximal portion of the tube with a liquid by introducing the liquid into the tube, allowing a portion of the liquid to flow out from the proximal end of the tube toward the site, and directing laser energy from a laser energy source into the distal end of the tube, whereby a portion of the laser energy emerges from the proximal end of the tube at the site. Also, such a method in which the liquid is a radiographic contrast medium. Also, such a method for removing an obstruction from a blood vessel in an animal. Also, apparatus for delivering laser energy to a site includes a flexible tube, a liquid, the tube having an opening in a first end through which the liquid can pass, means for providing a flow of the liquid into the tube, and a source of laser energy operationally associated with a second end of the tube, wherein the tube and the liquid are adapted to cooperate, when the tube contains the liquid, to conduct laser energy from the source and to emit a portion of the laser energy from the first end of the liquid-containing tube.

    摘要翻译： 用于向现场进行激光能量的方法包括以下步骤：使柔性管的近端靠近现场，通过将液体引入管中来填充液体的至少近端部分，允许液体的一部分 从管的近端向现场流出，并将来自激光能量源的激光能量引导到管的远端，由此一部分激光能量从位于管的近端处出现。 此外，这种液体是射线照相造影剂的方法。 此外，这种用于从动物的血管中除去阻塞物的方法。 而且，向场地传递激光能量的装置包括柔性管，液体，该管在第一端具有液体可以通过的开口，用于提供液体流入管的装置和 激光能量与管的第二端可操作地相关联，其中管和液体适于在管包含液体时协作以从源引入激光能量并从第一端发射一部分激光能量 的含液管。

    Method for contemporaneous application OF laser energy and localized pharmacologic therapy
    9.
    发明授权
    Method for contemporaneous application OF laser energy and localized pharmacologic therapy 失效
    方法同时应用激光能量和局部药理治疗

    公开(公告)号：US5817144A

    公开(公告)日：1998-10-06

    申请号：US728618

    申请日：1996-10-10

    申请人： Kenton W. Gregory

    发明人： Kenton W. Gregory

    IPC分类号： A61B17/22 ,  A61B18/00 ,  A61B18/24 ,  A61B19/00 ,  A61B5/00

    CPC分类号： A61B18/245 ,  A61B2017/22072 ,  A61B2017/22082 ,  A61B2017/22084 ,  A61B2018/00982 ,  A61B2090/306

    摘要： A method for contemporaneously applying laser energy and locally delivering pharmacologic therapy to a selected site in a body lumen using a liquid core or fiber optic laser catheter or angioscope. The method comprises preparing a solution of a pharmacologic agent, inserting the catheter into the lumen, directing the catheter to the site, transmitting visible light to the site, flowing the light transmissive liquid through the catheter to the site to be treated, positioning an emission end of the fiber near (.+-.2 mm) the distal end of the catheter, transmitting laser energy through the fiber to be emitted at the emission end of the fiber into the liquid to treat the site, and introducing a flow of the pharmacologic agent in solution into the catheter for contemporaneous discharge at the distal end into the lumen adjacent the site.

    摘要翻译： 一种同时使用激光能量并使用液体核心或光纤激光导管或血管造影术将体内治疗局部递送至体腔内选定部位的方法。 该方法包括制备药理学溶液，将导管插入内腔，将导管引导到现场，将可见光透射到现场，将透光液体通过导管流动到待治疗部位，定位排出物 在导管的远端（+/- 2mm）附近的纤维端部，通过纤维传输激光能量，以在纤维的发射端发射到液体中以治疗部位，并引入药物流 溶液中的药剂在导管中同时在远端排出到与该部位相邻的内腔中。