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公开(公告)号：US10533945B2
公开(公告)日：2020-01-14
申请号：US15808940
申请日：2017-11-10
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
IPC分类号： G01N21/64 , C12Q1/6874 , G01N21/77 , C12Q1/6869 , B01L3/00
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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2.发明授权公开(公告)号：US11428635B2
公开(公告)日：2022-08-30
申请号：US16028159
申请日：2018-07-05
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Anthony Bellofiore
IPC分类号： G01N21/64 , G01N21/77 , C12Q1/6869 , C12Q1/6874 , B01L3/00
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.
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公开(公告)号：US11287382B2
公开(公告)日：2022-03-29
申请号：US16689004
申请日：2019-11-19
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
IPC分类号： G01N21/64 , C12Q1/6874 , G01N21/77 , B01L3/00 , C12Q1/6869
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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公开(公告)号：US20220170861A1
公开(公告)日：2022-06-02
申请号：US17676070
申请日：2022-02-18
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
IPC分类号： G01N21/64 , C12Q1/6874 , G01N21/77 , B01L3/00 , C12Q1/6869
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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5.发明申请OPTICAL SYSTEM AND ASSAY CHIP FOR PROBING, DETECTING AND ANALYZING MOLECULES 有权用于探测，分析和分析分子的光学系统和测定芯片公开(公告)号：US20150177150A1
公开(公告)日：2015-06-25
申请号：US14543867
申请日：2014-11-17
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence West , Michael Ferrigno , Paul E. Glenn , Adam E. Cohen , Anthony Bellofiore
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , B01L3/5085 , B01L2200/12 , B01L2300/0829 , B01L2300/0887 , B01L2300/0893 , B01L2300/168 , C12Q1/6869 , C12Q1/6874 , C12Q2521/101 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607 , G01N21/64 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7743 , G01N21/7746 , G01N2021/6419 , G01N2021/6441 , G01N2021/6478 , G01N2201/02 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/068 , G01N2201/125 , Y10T29/49016 , C12Q2525/101
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
摘要翻译： 用于分析单分子和进行核酸测序的装置和方法。 装置可以包括测定芯片，其包括多个像素，其中样品阱被配置为接收样品，当被激发时，样品阱发射发射能量; 用于在特定方向上引导发射能量的至少一个元件; 以及发光能量从样品阱向传感器行进的光路。 该装置还包括与测定芯片接口的仪器。 仪器包括用于激发每个样品井中的样品的激发光源; 多个传感器对应于样品孔。 每个传感器可以检测来自相应样品阱中的样品的发射能量。 仪器包括至少一个光学元件，其将来自每个样品的发射能量引向多个传感器中的相应传感器。
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6.发明申请INTEGRATED DEVICE WITH EXTERNAL LIGHT SOURCE FOR PROBING DETECTING AND ANALYZING MOLECULES 审中-公开具有外部光源的集成器件用于探测和分析分子公开(公告)号：US20150141267A1
公开(公告)日：2015-05-21
申请号：US14543865
申请日：2014-11-17
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence West , Michael Ferrigno , Paul E. Glenn , Anthony Bellofiore
CPC分类号： G01N21/6486 , B01L3/5085 , B01L2200/12 , B01L2300/0829 , B01L2300/0887 , B01L2300/0893 , B01L2300/168 , C12Q1/6869 , C12Q1/6874 , C12Q2521/101 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607 , G01N21/64 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7743 , G01N21/7746 , G01N2021/6419 , G01N2021/6441 , G01N2021/6478 , G01N2201/02 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/068 , G01N2201/125 , Y10T29/49016 , C12Q2525/101
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.
摘要翻译： 用于分析单分子和进行核酸测序的装置和方法。 集成器件包括多个像素，其中样品阱被配置为接收样品，当被激发时，样品阱发射辐射; 用于在特定方向上引导发射辐射的至少一个元件; 以及发射辐射从样品阱向传感器行进的光路。 该装置还包括与集成装置接口的仪器。 每个传感器可以检测来自相应样品阱中的样品的发射辐射。 该仪器包括用于激发每个样品孔中的样品的激发光源。
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7.发明申请公开(公告)号：US20220364996A1
公开(公告)日：2022-11-17
申请号：US17877837
申请日：2022-07-29
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyartas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Anthony Bellofiore
IPC分类号： G01N21/64 , C12Q1/6874 , G01N21/77 , B01L3/00 , C12Q1/6869
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.
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8.发明申请公开(公告)号：US20190383737A1
公开(公告)日：2019-12-19
申请号：US16442206
申请日：2019-06-14
发明人： Jonathan M. Rothberg , Benjamin Cipriany , Faisal R. Ahmad , Joseph D. Clark , Daniel B. Frier , Michael Ferrigno , Mel Davey , Tom Thurston , Brett J. Gyarfas , Todd Rearick , Jeremy Christopher Jordan
摘要： Instrument control and data acquisition in advanced analytic systems that utilize optical pulses for sample analysis are described. Clocking signals for data acquisition, data processing, communication, and/or other data handling functionalities can be derived from an on-board pulsed optical source, such as a passively mode-locked laser. The derived clocking signals can operate in combination with one or more clocking signals from a stable oscillator, so that instrument operation and data handling can tolerate interruptions in operation of the pulsed optical source.
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9.发明申请公开(公告)号：US20180328850A1
公开(公告)日：2018-11-15
申请号：US16028159
申请日：2018-07-05
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Anthony Bellofiore
IPC分类号： G01N21/64 , B01L3/00 , C12Q1/6869 , C12Q1/6874 , G01N21/77
CPC分类号： G01N21/6486 , B01L3/5085 , B01L2200/12 , B01L2300/0829 , B01L2300/0887 , B01L2300/0893 , B01L2300/168 , C12Q1/6869 , C12Q1/6874 , C12Q2521/101 , C12Q2537/157 , C12Q2563/107 , C12Q2565/607 , G01N21/64 , G01N21/645 , G01N21/6452 , G01N21/648 , G01N21/7743 , G01N21/7746 , G01N2021/6419 , G01N2021/6441 , G01N2021/6478 , G01N2201/02 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/068 , G01N2201/125 , Y10T29/49016 , C12Q2525/101
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An integrated device includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits radiation; at least one element for directing the emission radiation in a particular direction; and a light path along which the emission radiation travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the integrated device. Each sensor may detect emission radiation from a sample in a respective sample well. The instrument includes an excitation light source for exciting the sample in each sample well.
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公开(公告)号：US20180088052A1
公开(公告)日：2018-03-29
申请号：US15808940
申请日：2017-11-10
发明人： Jonathan M. Rothberg , Ali Kabiri , Jason W. Sickler , Brett J. Gyarfas , Jeremy Lackey , Gerard Schmid , Benjamin Cipriany , Jack Jewell , Lawrence C. West , Michael Ferrigno , Paul E. Glenn , Adam Ezra Cohen , Anthony Bellofiore
摘要： Apparatus and methods for analyzing single molecule and performing nucleic acid sequencing. An apparatus can include an assay chip that includes multiple pixels with sample wells configured to receive a sample, which, when excited, emits emission energy; at least one element for directing the emission energy in a particular direction; and a light path along which the emission energy travels from the sample well toward a sensor. The apparatus also includes an instrument that interfaces with the assay chip. The instrument includes an excitation light source for exciting the sample in each sample well; a plurality of sensors corresponding the sample wells. Each sensor may detect emission energy from a sample in a respective sample well. The instrument includes at least one optical element that directs the emission energy from each sample well towards a respective sensor of the plurality of sensors.
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