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1.发明授权7-(substituted)-8-(substituted)-9-[(substituted glycyl) amido]-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-8-（取代的）-9 - [（取代的甘氨酰基）酰胺基] -6-脱甲基-6-脱氧四环素
公开(公告)号：US5386041A
公开(公告)日：1995-01-31
申请号：US193828
申请日：1994-02-08
Applicant: Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
IPC: C07D295/12 , A61K31/397 , A61K31/445 , A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C239/20 , C07C255/41 , C07C309/39 , C07C309/65 , C07C323/59 , C07D205/04 , C07D205/12 , C07D207/06 , C07D207/16 , C07D207/32 , C07D207/327 , C07D211/34 , C07D213/56 , C07D231/12 , C07D233/60 , C07D233/61 , C07D239/26 , C07D265/02 , C07D265/30 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/24 , C07D307/54 , C07D401/06 , C07D487/04 , C07D487/08 , C07D521/00 , C07C235/66
CPC classification number: C07D207/327 , C07C237/26 , C07D205/04 , C07D207/16 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/02 , C07D295/15 , C07D295/24 , C07D307/54 , C07D487/04 , C07C2101/02 , C07C2101/04 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供下式的化合物：其中R，R 3，R 4，X和W在说明书中定义。 这些化合物可用作抗生素。
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2.发明授权Process for the production of 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines 失效制备7-（取代的）-9 - [（取代的甘氨酰）酰氨基] -6-脱甲基-6-脱氧四环素的方法
公开(公告)号：US5495031A
公开(公告)日：1996-02-27
申请号：US304913
申请日：1994-09-13
Applicant: Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
IPC: A61K31/16 , A61K31/40 , A61K31/403 , A61K31/425 , A61K31/428 , A61K31/65 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C255/50 , C07C255/52 , C07C317/28 , C07D207/16 , C07D209/02 , C07D211/14 , C07D211/22 , C07D211/26 , C07D213/36 , C07D213/38 , C07D233/56 , C07D233/64 , C07D237/26 , C07D249/04 , C07D249/08 , C07D261/08 , C07D265/30 , C07D277/64 , C07D293/00 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/30 , C07D307/32 , C07D207/18
CPC classification number: C07D295/30 , C07C237/26 , C07D207/16 , C07D213/38 , C07D295/13 , C07D295/15 , C07C2101/02 , C07C2103/46
Abstract: The invention provides a process for the production of compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification in which a compound of the following formula: ##STR2## is reacted with a nucleophile of the formula WH in an inert atmosphere in the presence of a polar aprotic solvent. The resulting compounds are useful as antibiotics.
Abstract translation: 本发明提供了一种制备下式的化合物的方法：其中R，R 3，R 4和W在本说明书中定义，其中下式的化合物与下式的亲核试剂反应： WH在极性非质子溶剂存在下在惰性气氛中。 所得化合物可用作抗生素。
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3.发明授权7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-9 - [（取代的甘氨酰基）酰胺基] -6-脱甲基-6-脱氧四环素
公开(公告)号：US5466684A
公开(公告)日：1995-11-14
申请号：US304731
申请日：1994-09-12
Applicant: Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
IPC: A61K31/16 , A61K31/40 , A61K31/403 , A61K31/425 , A61K31/428 , A61K31/65 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C255/50 , C07C255/52 , C07C317/28 , C07D207/16 , C07D209/02 , C07D211/14 , C07D211/22 , C07D211/26 , C07D213/36 , C07D213/38 , C07D233/56 , C07D233/64 , C07D237/26 , C07D249/04 , C07D249/08 , C07D261/08 , C07D265/30 , C07D277/64 , C07D293/00 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/30 , C07D307/32
CPC classification number: C07D295/30 , C07C237/26 , C07D207/16 , C07D213/38 , C07D295/13 , C07D295/15 , C07C2101/02 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供下式的化合物：其中R，R 3，R 4和W在说明书中定义。 这些化合物可用作抗生素。
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4.发明授权
公开(公告)号：US5442059A
公开(公告)日：1995-08-15
申请号：US928590
申请日：1992-08-13
Applicant: Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
IPC: A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C237/26 , C07C239/18 , C07C239/20 , C07C255/50 , C07C271/22 , C07C323/29 , C07D207/06 , C07D207/14 , C07D207/16 , C07D207/30 , C07D209/02 , C07D211/14 , C07D211/56 , C07D213/40 , C07D213/74 , C07D221/22 , C07D231/12 , C07D231/14 , C07D241/04 , C07D241/14 , C07D249/02 , C07D249/04 , C07D249/08 , C07D265/28 , C07D279/04 , C07D295/14 , C07D295/15 , C07D295/215 , C07D295/24 , C07D307/33 , C07D333/20 , C07D333/36 , C07F15/00 , C07C231/12 , C07C233/64
CPC classification number: C07D213/40 , C07C237/26 , C07C239/18 , C07C239/20 , C07C271/22 , C07D295/15 , C07D295/215 , C07D295/24 , C07D333/20 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, and R.sup.1 and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供下式的化合物：说明书。 这些化合物可用作抗生素。
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5.发明授权9-[(substituted glycyl) amido)]-6-demethyl-6-deoxytetracyclines 失效9 - [（取代甘氨酰）酰氨基）] - 6-脱甲基-6-脱氧四环素
公开(公告)号：US5567692A
公开(公告)日：1996-10-22
申请号：US443612
申请日：1995-05-18
Applicant: Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
IPC: A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C237/26 , C07C239/18 , C07C239/20 , C07C255/50 , C07C271/22 , C07C323/29 , C07D207/06 , C07D207/14 , C07D207/16 , C07D207/30 , C07D209/02 , C07D211/14 , C07D211/56 , C07D213/40 , C07D213/74 , C07D221/22 , C07D231/12 , C07D231/14 , C07D241/04 , C07D241/14 , C07D249/02 , C07D249/04 , C07D249/08 , C07D265/28 , C07D279/04 , C07D295/14 , C07D295/15 , C07D295/215 , C07D295/24 , C07D307/33 , C07D333/20 , C07D333/36 , C07F15/00
CPC classification number: C07D213/40 , C07C237/26 , C07C239/18 , C07C239/20 , C07C271/22 , C07D295/15 , C07D295/215 , C07D295/24 , C07D333/20 , C07C2103/46
Abstract: The invention provides a method for prevention, treatment or control of bacterial infections in warm blooded animals by administering a pharmacologically effect amount of a compound of the formula: ##STR1## wherein R, R.sup.1 and W are defined in the specification.
Abstract translation: 本发明提供了一种通过施用药理作用量的下式化合物其中R，R 1和W在说明书中定义的方法来预防，治疗或控制温血动物细菌感染的方法。
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Patent Agency Ranking6.发明授权7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-9 - [（取代的甘氨酰基）酰胺基] -6-脱甲基-6-脱氧四环素
公开(公告)号：US5328902A
公开(公告)日：1994-07-12
申请号：US928589
申请日：1992-08-13
Applicant: Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
IPC: A61K31/16 , A61K31/40 , A61K31/403 , A61K31/425 , A61K31/428 , A61K31/65 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C255/50 , C07C255/52 , C07C317/28 , C07D207/16 , C07D209/02 , C07D211/14 , C07D211/22 , C07D211/26 , C07D213/36 , C07D213/38 , C07D233/56 , C07D233/64 , C07D237/26 , C07D249/04 , C07D249/08 , C07D261/08 , C07D265/30 , C07D277/64 , C07D293/00 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/30 , C07D307/32 , C07D221/02 , C07D207/04 , C07D207/18 , C07D207/30 , C07D221/08
CPC classification number: C07D295/30 , C07C237/26 , C07D207/16 , C07D213/38 , C07D295/13 , C07D295/15 , C07C2101/02 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供下式的化合物：说明书。 这些化合物可用作抗生素。
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7.发明授权7-(substituted)-8-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-8-（取代的）-9 - [（取代的甘氨酰基）酰胺基] -6-脱甲基-6-脱氧四环素
公开(公告)号：US5457096A
公开(公告)日：1995-10-10
申请号：US312018
申请日：1994-09-26
Applicant: Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
IPC: C07D295/12 , A61K31/397 , A61K31/445 , A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C239/20 , C07C255/41 , C07C309/39 , C07C309/65 , C07C323/59 , C07D205/04 , C07D205/12 , C07D207/06 , C07D207/16 , C07D207/32 , C07D207/327 , C07D211/34 , C07D213/56 , C07D231/12 , C07D233/60 , C07D233/61 , C07D239/26 , C07D265/02 , C07D265/30 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/24 , C07D307/54 , C07D401/06 , C07D487/04 , C07D487/08 , C07D521/00
CPC classification number: C07D207/327 , C07C237/26 , C07D205/04 , C07D207/16 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/02 , C07D295/15 , C07D295/24 , C07D307/54 , C07D487/04 , C07C2101/02 , C07C2101/04 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供下式的化合物：其中R，R 3，R 4，X和W在说明书中定义。 这些化合物可用作抗生素。
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8.发明授权7-(substituted)-8-(substituted)-9-substituted amino)-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-8-（取代的）-9-取代的氨基）-6-脱甲基-6-脱氧四环素
公开(公告)号：US5430162A
公开(公告)日：1995-07-04
申请号：US214992
申请日：1994-03-21
Applicant: Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
IPC: A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C237/26 , C07C239/18 , C07C243/20 , C07C245/20 , C07C247/18 , C07C255/41 , C07C271/24 , C07C271/60 , C07C309/39 , C07C309/65 , C07C317/28 , C07C323/59 , C07D205/04 , C07D207/16 , C07D209/52 , C07D221/22 , C07D231/14 , C07D233/61 , C07D233/96 , C07D241/12 , C07D249/04 , C07D249/08 , C07D249/10 , C07D249/16 , C07D257/04 , C07D261/08 , C07D265/30 , C07D265/36 , C07D279/12 , C07D295/08 , C07D295/14 , C07D295/20 , C07D295/22 , C07D307/18 , C07D333/06 , C07D333/36 , C07D453/06 , C07D471/08 , C07D487/08 , C07C233/64 , C07C235/32
CPC classification number: C07C237/26 , C07C243/20 , C07C245/20 , C07C247/18 , C07C271/24 , C07C271/60 , C07C309/65 , C07C2103/46
Abstract: The invention provides compounds of formula ##STR1## wherein X, R and R.sup.1 are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供式I的化合物，其中X，R和R 1在本说明书中定义。 这些化合物可用作抗生素。
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9.发明授权7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines 失效7-（取代的）-8-（取代的）-9 - ]（取代的甘氨酰基）酰胺基] -6-脱甲基-6-脱氧四环素
公开(公告)号：US5420272A
公开(公告)日：1995-05-30
申请号：US928578
申请日：1992-08-13
Applicant: Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Joseph J. Hlavka , Raymond T. Testa
IPC: C07D295/12 , A61K31/397 , A61K31/445 , A61K31/65 , A61P31/00 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C239/20 , C07C255/41 , C07C309/39 , C07C309/65 , C07C323/59 , C07D205/04 , C07D205/12 , C07D207/06 , C07D207/16 , C07D207/32 , C07D207/327 , C07D211/34 , C07D213/56 , C07D231/12 , C07D233/60 , C07D233/61 , C07D239/26 , C07D265/02 , C07D265/30 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/24 , C07D307/54 , C07D401/06 , C07D487/04 , C07D487/08 , C07D521/00 , C07C233/64
CPC classification number: C07D207/327 , C07C237/26 , C07D205/04 , C07D207/16 , C07D213/56 , C07D231/12 , C07D233/56 , C07D249/08 , C07D265/02 , C07D295/15 , C07D295/24 , C07D307/54 , C07D487/04 , C07C2101/02 , C07C2101/04 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4, X and W are defined in the specification. These compounds are useful as antibiotic agents.
Abstract translation: 本发明提供了在本说明书中所述的下式的化合物。 这些化合物可用作抗生素。
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公开(公告)号：US5380888A
公开(公告)日：1995-01-10
申请号：US205009
申请日：1994-03-02
Applicant: Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
Inventor： Phaik-Eng Sum , Ving J. Lee , Raymond T. Testa
IPC: A61K31/16 , A61K31/40 , A61K31/403 , A61K31/425 , A61K31/428 , A61K31/65 , A61P31/04 , C07C20060101 , C07C231/12 , C07C237/26 , C07C255/50 , C07C255/52 , C07C317/28 , C07D207/16 , C07D209/02 , C07D211/14 , C07D211/22 , C07D211/26 , C07D213/36 , C07D213/38 , C07D233/56 , C07D233/64 , C07D237/26 , C07D249/04 , C07D249/08 , C07D261/08 , C07D265/30 , C07D277/64 , C07D293/00 , C07D295/12 , C07D295/13 , C07D295/14 , C07D295/15 , C07D295/22 , C07D295/30 , C07D307/32 , C07C235/66
CPC classification number: C07D295/30 , C07C237/26 , C07D207/16 , C07D213/38 , C07D295/13 , C07D295/15 , C07C2101/02 , C07C2103/46
Abstract: The invention provides compounds of the formula: ##STR1## wherein R, R.sup.3, R.sup.4 and W are defined in the specification. These compounds are useful as antibiotic agents.
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