公开(公告)号：US5186596A

公开(公告)日：1993-02-16

申请号：US770836

申请日：1991-10-04

申请人： Paul Boucher ,  Mario Boucher ,  John Ford ,  Gregg Stephenson

发明人： Paul Boucher ,  Mario Boucher ,  John Ford ,  Gregg Stephenson

IPC分类号： B65G67/20

CPC分类号： B65G67/20

摘要： A longitudinal extensible platform comprises a plurality of framed sections hingedly joined together. Each framed section comprises a first set of ground engaging rollers and a second set of load engaging rollers extending transversely of the framed section. A drive is mounted below the surface of the loading dock for driving an endless chain. The extensible platform is drivingly engaged to the endless chain and adapted for longitudinal movement therealong. The extensible platform has a platen at a forward end hingedly engaging the first framed section. The extensible platform is provided with a driven pusher assembly mounted thereon. The pusher assembly extending upwardly for abutting with the load resting on the extensible platform.

摘要翻译： 纵向可伸展平台包括铰接在一起的多个框架部分。 每个框架部分包括第一组地面接合辊和横向于框架部分延伸的第二组负载接合辊。 驱动器安装在装载底座的表面下方，用于驱动环形链条。 可伸缩平台被驱动地接合到环形链条上，适用于纵向运动。 可伸展平台在前端具有与第一框架部分铰接接合的压板。 可伸展平台设置有安装在其上的从动推动器组件。 推动器组件向上延伸以与搁置在可延伸平台上的负载邻接。

公开(公告)号：US08000436B2

公开(公告)日：2011-08-16

申请号：US12080860

申请日：2008-04-07

申请人： Edward J. Seppi ,  John Ford ,  Marcel Marc

发明人： Edward J. Seppi ,  John Ford ,  Marcel Marc

IPC分类号： G01N23/00

CPC分类号： G01V5/005 ,  G01N23/046 ,  G01N2223/419

摘要： A scanning unit for inspecting objects comprises in one example a radiation source, a movable platform to support an object, and a detector positioned to receive radiation after interaction of radiation with the object. The platform is movable at least partially within a cavity defined, at least partially, below at least one of the source or the detector. In another scanning unit, a first conveyor conveys an object to a movable platform, and second and third conveyors convey the object from the platform. The second and third conveyors are at different vertical heights. In another scanning unit, images from an energy sensitive detector and a spatial detector are fused. In a method, scanning parameters during CT scanning are changed and images reconstructed before and after the change. In another method, an object is scanned with X-ray beams having first and second energy distributions, generated by the same X-ray source.

摘要翻译： 用于检查物体的扫描单元在一个示例中包括辐射源，用于支撑物体的可移动平台以及定位成在辐射与物体相互作用之后接收辐射的检测器。 该平台至少部分地在至少部分地在源或检测器中的至少一个之下限定的空腔内移动。 在另一个扫描单元中，第一输送器将物体传送到可移动平台，第二和第三输送机从平台传送物体。 第二和第三输送机处于不同的垂直高度。 在另一个扫描单元中，来自能量敏感检测器和空间检测器的图像被融合。 在一种方法中，CT扫描期间的扫描参数被改变，并且在改变之前和之后重建图像。 在另一种方法中，用具有由相同X射线源产生的第一和第二能量分布的X射线束扫描物体。

公开(公告)号：US20100087428A1

公开(公告)日：2010-04-08

申请号：US12550860

申请日：2009-08-31

申请人： Mushtaq Mulla ,  Derek Edward John ,  Richard John Hamlyn ,  Sasha Louise Garrett ,  Basil Hartzoulakis ,  David Madge ,  John Ford

发明人： Mushtaq Mulla ,  Derek Edward John ,  Richard John Hamlyn ,  Sasha Louise Garrett ,  Basil Hartzoulakis ,  David Madge ,  John Ford

IPC分类号： A61K31/415 ,  C07D231/04 ,  C07D233/66 ,  C07D213/62 ,  C07D265/36 ,  A61K31/4164 ,  A61K31/44 ,  A61K31/538 ,  A61P19/02 ,  A61P17/06 ,  A61P37/00

CPC分类号： C07C311/21 ,  C07C311/46 ,  C07C317/32 ,  C07C317/40 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D207/12 ,  C07D209/08 ,  C07D211/16 ,  C07D211/34 ,  C07D211/44 ,  C07D213/36 ,  C07D213/40 ,  C07D213/71 ,  C07D231/12 ,  C07D231/18 ,  C07D231/56 ,  C07D233/61 ,  C07D233/64 ,  C07D233/84 ,  C07D265/30 ,  C07D265/36 ,  C07D271/08 ,  C07D277/28 ,  C07D277/36 ,  C07D277/46 ,  C07D285/12 ,  C07D285/135 ,  C07D307/79 ,  C07D311/70 ,  C07D317/62 ,  C07D319/18 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

摘要： The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein; X1 is selected from a group consisting of CH2, C(═O), C(═NH), NC(═O), R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl R2 is selected from the group consisting of optionally substituted alkyl, optionally substituted aryl or heteroaryl or NR24R25 R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, aryloxy, optionally substituted alkyl, optionally substituted amino, optionally substituted amino sulfonyl or nitrile; R4 is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted acyl, optionally substituted sulfonyl, optionally substituted sulfamoyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroaryl R5 may be hydrogen, an optionally substituted alkyl, preferably CH3 or, NR4R5 may form an optionally substituted saturated or partially saturated 4-7 membered ring with the general formula (II). Wherein; X2 is C(═O), CH2, CH(R6) or C(R6)(R6), X3 is CH2, CH(R7), C(R7)(R7), NH, N(R8), O or S Each R6 independently represents optionally substituted amino, optionally substituted amino carbonyl, hydroxyl, optionally substituted acyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalky, optionally substituted aryl or optionally substituted heteroaryl; Each R7 independently represents optionally substituted amino, optionally substituted amino carbonyl, hydroxyl, optionally substituted acyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalky, optionally substituted aryl or optionally substituted hetero aryl R8 is optionally substituted acyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; R24 and R25 are the same or different and each represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl, n=1 or 2 m=1, 2 or 3 With the proviso that when X1 is C═O and R5 is H then R4 is not: Or Or Where R4a, R5a and R6a are each independently H, C1-6alkyl, aryl, heteroaryl, cycloalkyl, or aryl-C1-6alkyl; R10a is H or C1-6alkyl; and R11a is C1-6alkyl or aryl-C1-6alkyl and when X1 is C═O or CH2 and R5 is H then R4 is not: Where q is 0 to 5, R3b is H, OH or alkoxy and R4b is NH2, phenyl or a C3-10 heterocycle. The compounds are useful as potassium ion channel inhibitors.

公开(公告)号：US20070222433A1

公开(公告)日：2007-09-27

申请号：US11386449

申请日：2006-03-21

申请人： Timothy Tiernan ,  John Ford

发明人： Timothy Tiernan ,  John Ford

IPC分类号： H01L41/00 ,  G01B7/30 ,  G01V3/00

CPC分类号： G01R33/3415 ,  A61B5/04005 ,  A61B5/04007 ,  A61B5/062 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/687 ,  A61B2562/043 ,  G01R33/286 ,  G01R33/323 ,  G01R33/34084 ,  G01R33/3806 ,  G01R33/5617

摘要： The present invention generally provides improved devices, systems, and methods for measuring materials with NMR and/or MRI. Exemplary embodiments provide a sensor array for NMR mapping of the material. For example tissue can be measured with the sensor array mounted on a probe body having a distal portion which can be inserted through a minimally invasive aperture. While many tissues can be measured and/or diagnosed, one exemplary embodiment includes a probe adapted for insertion into a lumen of a blood vessel. The sensor array can provide improved spatial resolution of tissue and/or tissue structures positioned near the sensor array to diagnose potentially life threatening diseases, for example a fibrous cap covering a vulnerable plaque. In specific embodiments, the sensors are attached to an expandable member, for example a balloon, which can be inflated to urge the probe sensors radially outward to position the sensors near the tissue structures.

摘要翻译： 本发明通常提供用NMR和/或MRI测量材料的改进的装置，系统和方法。 示例性实施例提供用于材料的NMR映射的传感器阵列。 例如，可以用传感器阵列测量组织，传感器阵列安装在具有远端部分的探针主体上，该远端部分可插入通过微创孔径。 虽然可以测量和/或诊断许多组织，但是一个示例性实施例包括适于插入血管内腔的探针。 传感器阵列可以提供设置在传感器阵列附近的组织和/或组织结构的改进的空间分辨率，以诊断潜在的威胁生命的疾病，例如覆盖易损斑块的纤维帽。 在具体实施例中，传感器附接到可膨胀构件，例如球囊，其可以被膨胀以将探针传感器径向向外推动以将传感器定位在组织结构附近。

公开(公告)号：US20060204521A1

公开(公告)日：2006-09-14

申请号：US11435142

申请日：2006-05-17

申请人： John Hermon-Taylor ,  Tim Doran ,  Douglas Millar ,  Mark Tizard ,  Mark Loughlin ,  Nazira Sumar ,  John Ford

发明人： John Hermon-Taylor ,  Tim Doran ,  Douglas Millar ,  Mark Tizard ,  Mark Loughlin ,  Nazira Sumar ,  John Ford

IPC分类号： A61K39/02 ,  C07H21/02 ,  C12N1/21 ,  C12N15/86 ,  C12N15/74 ,  C07H21/04

CPC分类号： C07K14/35 ,  A61K38/00

摘要： The invention provides a nucleotide sequence representing a pathogenicity island found in species of pathogenic mycobacteria. The islands are shown as SEQ ID NOS: 3 and 4 and comprises several open reading frames encoding polypeptides. These polypeptides and their use in diagnosis and therapy form a further aspect of the invention.

摘要翻译： 本发明提供了表示在致病性分枝杆菌种中发现的致病性岛的核苷酸序列。 这些岛被显示为SEQ ID NO：3和4，并且包含编码多肽的几个开放阅读框。 这些多肽及其在诊断和治疗中的用途形成本发明的另一方面。

公开(公告)号：US07001731B2

公开(公告)日：2006-02-21

申请号：US10101673

申请日：2002-03-18

申请人： John Ford ,  George Yeung

发明人： John Ford ,  George Yeung

IPC分类号： G01N33/53 ,  C07K16/00 ,  C07K21/08

CPC分类号： C07K14/7158

摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and fetal liver as well as polypeptides encoded by these polynucleotides. The polypeptide is a human chemokine receptor that is a member of a family of G protein-coupled receptors characterized by seven transmembrane domains. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing chemokine receptor polypeptides, and antibodies specific for such polypeptides.

公开(公告)号：US20050288664A1

公开(公告)日：2005-12-29

申请号：US11145743

申请日：2005-06-06

申请人： John Ford ,  Scott West ,  John Gaiser ,  Patrick Rimroth

发明人： John Ford ,  Scott West ,  John Gaiser ,  Patrick Rimroth

IPC分类号： A61B18/14 ,  A61B18/18

CPC分类号： A61B18/1477 ,  A61B18/1492 ,  A61B2018/00214 ,  A61B2018/00267 ,  A61B2018/00494 ,  A61B2018/00916 ,  A61B2018/1425

摘要： Systems and methods deploy an electrode from a catheter assembly. The systems and methods provide a catheter handle having a trigger lever adapted to carry an actuator rod. The actuator rod is adapted to cause movement of the electrode between a retracted position and an extended position. A pinion is carried by the trigger lever for engagement with a rack carried by the actuator rod. Compression of the trigger lever moves the rack along the actuator rod between a first position corresponding to the electrodes being in the retracted position and a second position corresponding to either the primed electrode firing position or the electrodes being in an extended position.

摘要翻译： 系统和方法从导管组件部署电极。 该系统和方法提供了具有适于承载致动器杆的触发杆的导管手柄。 致动器杆适于使电极在缩回位置和延伸位置之间移动。 小齿轮由触发杆承载，用于与由致动器杆承载的齿条接合。 触发杆的压缩沿着致动器杆在对应于处于缩回位置的电极的第一位置和对应于引脚电极触发位置或电极处于伸出位置的第二位置之间移动机架。

公开(公告)号：US06502905B2

公开(公告)日：2003-01-07

申请号：US09836749

申请日：2001-04-17

申请人： Albert B. Cheris ,  John Ford ,  Michael Goluszka

发明人： Albert B. Cheris ,  John Ford ,  Michael Goluszka

IPC分类号： A47C1602

CPC分类号： B60N3/063 ,  A47C16/02 ,  B60N3/04 ,  Y10T428/24008 ,  Y10T428/24314

摘要： A plastic floor mat and foot rest unit is disclosed in which a front edge of the support surface of the foot rest is inserted through a slotted opening in the floor mat to the underside of the floor mat, and a latching projection is also inserted through the opening to latch the front edge of the support surface in the opening, yet permit its ready removal if desired. The rear edge of the support surface is also supported by a support plate to permit the incline angle of the foot rest support surface to be adjusted and to support the rear edge by the pile of the carpet upon which the floor mat and foot rest unit is to be used.

摘要翻译： 公开了一种塑料地板垫和脚踏板单元，其中脚垫的支撑表面的前边缘通过地板垫中的开槽开口插入到地板垫的下侧，并且闩锁突起也插入通过 打开以将开口中的支撑表面的前边缘锁定，但如果需要，允许其准备移除。 支撑表面的后边缘还由支撑板支撑，以允许脚踏支撑表面的倾斜角度被调节，并且通过地板垫和脚踏板单元所在的地毯的绒头来支撑后边缘 要使用的。

公开(公告)号：US06497870B1

公开(公告)日：2002-12-24

申请号：US09576755

申请日：2000-05-22

申请人： John Ford ,  Alice Suk-Yue Ho

发明人： John Ford ,  Alice Suk-Yue Ho

IPC分类号： A61K4500

CPC分类号： C07K14/54 ,  A61K38/00 ,  Y02A50/41

摘要： The present invention provides novel therapeutic methods of administering an amount of IL-1Ra to treat IL-18 related disorders. Specifically, the method involves treating IL-18 related disorders such as liver injury, hepatis, hemophagocytic lymphohistiocytosis, multiple sclerosis, tumors, cytotoxicity resulting from antitumor therapy, or other autoimmune disorders with a therapeutically effective amount of IL-1ra, and optionally measuring IFN-&ggr; and IL-18 activity from human samples.

摘要翻译： 本发明提供了施用一定量的IL-1Ra以治疗IL-18相关病症的新型治疗方法。 具体地说，该方法包括治疗IL-18相关疾病如肝损伤，肝细胞，嗜血细胞淋巴组织细胞增多症，多发性硬化，肿瘤，抗肿瘤治疗引起的细胞毒性或其它具有治疗有效量的IL-1ra的自身免疫性疾病，以及任选地测量IFN -γ和IL-18活性。

公开(公告)号：US06387645B1

公开(公告)日：2002-05-14

申请号：US09350836

申请日：1999-07-09

申请人： John Ford ,  Julio J. Mulero

发明人： John Ford ,  Julio J. Mulero

IPC分类号： C12Q142

CPC分类号： C12N9/14 ,  A61K38/00 ,  C07K14/70596

摘要： The invention provides novel polynucleotides isolated from cDNA libraries of human fetal liver-spleen and macrophage as well as polypeptides encoded by these polynucleotides and mutants or variants thereof. The polypeptides correspond to a novel human CD39-like protein. Other aspects of the invention include vectors containing polynucleotides of the invention and related host cells as well a processes for producing novel CD39-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供从人胎儿肝脾和巨噬细胞的cDNA文库中分离的新型多核苷酸，以及由这些多核苷酸及其突变体或变体编码的多肽。 多肽对应于新的人CD39样蛋白。 本发明的其它方面包括含有本发明多核苷酸和相关宿主细胞的载体以及产生新型CD39样多肽的方法，以及对这些多肽具有特异性的抗体。