公开(公告)号：US11672468B2

公开(公告)日：2023-06-13

申请号：US16097457

申请日：2017-04-28

Applicant: WASHINGTON UNIVERSITY

Inventor： Yong Wang ,  Qing Wang ,  Tammie Benzinger

IPC: A61B5/00 ,  A61B5/055 ,  G01R33/563 ,  G01R33/48 ,  G01R33/561 ,  G01R33/565

CPC classification number: A61B5/4088 ,  A61B5/055 ,  A61B5/4064 ,  G01R33/4806 ,  G01R33/56341 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/56509

Abstract: Methods and systems for diagnosing a condition of a central nervous system are provided. A method includes providing a DBSI-MRI data set obtained from the central nervous system of the subject, and transforming the DBSI-MRI data set to obtain at least one DBSI biomarker value. The method further includes comparing each DBSI biomarker value to at least one corresponding threshold value from a diagnostic database to obtain a relation between each DBSI biomarker value and the at least one corresponding threshold value, and diagnosing the condition according to at least one diagnostic rule, wherein each diagnostic rule defines a candidate condition in terms of the relations between the at least one DBSI biomarker value and the at least one corresponding threshold value.

公开(公告)号：US20190154784A1

公开(公告)日：2019-05-23

申请号：US15820681

申请日：2017-11-22

Applicant: Siemens Healthcare GmbH

Inventor： Daniel Polak ,  Yen Mei Lisa Chuah ,  Esther Raithel

IPC: G01R33/561 ,  G01R33/48 ,  G01R33/56 ,  G01R33/58 ,  G01R33/565

CPC classification number: G01R33/5617 ,  G01R33/4818 ,  G01R33/4822 ,  G01R33/5608 ,  G01R33/5611 ,  G01R33/56509 ,  G01R33/56545 ,  G01R33/583

Abstract: Magnetic resonance (MR) data are acquired by applying magnetic fields to an examination region concurrent with stimulated echo signals, such that trajectories, which are not straight lines, are generated in k-space. For this purpose, sequence of RF pulses is applied to generate the stimulated echo signals in the examination object, undersampled MR measurement data are detected during reception of the stimulated echo signals in the at least two receiving coils, along the curved k-space trajectories, and fully sampled MR measurement are generated from the undersampled MR measurement data using sensitivity information of the at least two receiving coils. Alternatively, the MR measurement data are fully sampled in a central region of k-space, and a region outside the central region is not fully sampled, and a phase correction with a Partial Fourier technique is executed on the MR measurement data using fully sampled MR measurement data from the central region of k-space.

公开(公告)号：US20190150822A1

公开(公告)日：2019-05-23

申请号：US16097457

申请日：2017-04-28

Applicant: Yong Wang ,  Qing Wang ,  Tammie Benzinger

Inventor： Yong Wang ,  Qing Wang ,  Tammie Benzinger

IPC: A61B5/00 ,  A61B5/055

CPC classification number: A61B5/4088 ,  A61B5/055 ,  A61B5/4064 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/56341 ,  G01R33/56509

Abstract: Methods and systems for diagnosing a condition of a central nervous system are provided. A method includes providing a DBSI-MRI data set obtained from the central nervous system of the subject, and transforming the DBSI-MRI data set to obtain at least one DBSI biomarker value. The method further includes comparing each DBSI biomarker value to at least one corresponding threshold value from a diagnostic database to obtain a relation between each DBSI biomarker value and the at least one corresponding threshold value, and diagnosing the condition according to at least one diagnostic rule, wherein each diagnostic rule defines a candidate condition in terms of the relations between the at least one DBSI biomarker value and the at least one corresponding threshold value.

公开(公告)号：US20190049536A1

公开(公告)日：2019-02-14

申请号：US16161401

申请日：2018-10-16

Applicant: GENERAL ELECTRIC COMPANY

Inventor： Dawei Gui ,  Anton M. Linz ,  Ajeetkumar Gaddipati ,  Xiaoli Zhao ,  Shaorong Chang ,  Donglai Huo

IPC: G01R33/385 ,  G01R33/48

CPC classification number: G01R33/3854 ,  G01R33/4824 ,  G01R33/4826 ,  G01R33/5617

Abstract: A system and method for reducing MRI-generated acoustic noise is disclosed. A system control of an MRI apparatus causes a plurality of gradient coils and an RF coil assembly in the MRI apparatus to generate pulse sequences that each cause an echo train to form and acquire blades of k-space data of the subject of interest from the pulse sequences, with the blades being rotated about a section of k-space compared to every other blade. The system control also causes the plurality of gradient coils to generate gradient pulses in each pulse sequence having an optimized gradient waveform that reduces an acoustic noise level generated thereby and causes the RF coil assembly to generate a 180 degree prep pulse subsequent to generation of an RF excitation pulse and prior to generation of a first RF refocusing pulse, the 180 degree prep pulse minimizing echo spacing in the echo train.

公开(公告)号：US20180329009A1

公开(公告)日：2018-11-15

申请号：US16044393

申请日：2018-07-24

Applicant: bioProtonics, LLC

Inventor： Kristin James ,  Timothy W. James

IPC: G01R33/56 ,  G01R33/561 ,  G06T7/00 ,  G01R33/563 ,  A61B5/055

CPC classification number: G01R33/5601 ,  A61B5/055 ,  A61B5/7203 ,  A61B5/7207 ,  A61B2560/0238 ,  G01R33/4818 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/5619 ,  G01R33/56341 ,  G06T7/0012 ,  G06T2207/10088

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

公开(公告)号：US10073159B2

公开(公告)日：2018-09-11

申请号：US14116421

申请日：2012-05-23

Applicant: Shinji Kurokawa

Inventor： Shinji Kurokawa

IPC: G01V3/00 ,  G01R33/56 ,  G01R33/561 ,  G01R33/58 ,  G01R33/54

CPC classification number: G01R33/56 ,  G01R33/543 ,  G01R33/5617 ,  G01R33/583

Abstract: In order to maximize the SNR of an image in consideration of signal correction in a multi-echo sequence, flip angles of a plurality of refocus high frequency magnetic field pulses are determined in a multi-echo imaging sequence. Using an index that reflects the SNR of an image after signal correction of a plurality of acquired echo signals, a flip angle at which the SNR of the image becomes a maximum is determined by repeatedly calculating the index by changing information specifying the flip angle of each refocus RF pulse according to an optimization method set in advance.

公开(公告)号：US20180252789A1

公开(公告)日：2018-09-06

申请号：US15754239

申请日：2016-08-29

Applicant: The Regents of the University of California

Inventor： Benjamin Ellingson ,  Kevin Leu

IPC: G01R33/561 ,  A61B5/055 ,  G01R33/50 ,  A61B5/00 ,  G01R33/48

CPC classification number: G01R33/5616 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/407 ,  G01R33/4806 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5617 ,  G01R33/56366

Abstract: An echo planar imaging technique in which a quadruple echo gradient and spin echo echo-planar imaging pulse sequence is utilized. The pulse train includes generation of two echo trains between an excitation pulse (90) and a refocusing pulse (180) to achieve two gradient echo images (also called T2*-weighted images); with one echo train directly after the 180 pulse, leading to asymmetric spin echo images (T2′-weighted images); and a last echo train afterward that generates spin echo images (T2-weighted). The technique has a number of advantages over existing techniques with regard to voxel size, mapping relative oxygen extraction, determining permeability, determining relative cerebral blood volume, vessel parameters (diameter, density, size, arterial/venous, etc.), stroke imaging, imaging perfusion, fMRI imaging, and additional benefits.

公开(公告)号：US10061003B2

公开(公告)日：2018-08-28

申请号：US15604465

申请日：2017-05-24

Applicant: bioProtonics, LLC

Inventor： Kristin James ,  Timothy W. James

IPC: G01R33/56 ,  G01R33/561 ,  G06T7/00

CPC classification number: G01R33/5601 ,  A61B5/055 ,  A61B5/7203 ,  A61B5/7207 ,  A61B2560/0238 ,  G01R33/4818 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/5619 ,  G01R33/56341 ,  G06T7/0012 ,  G06T2207/10088

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

公开(公告)号：US10012712B2

公开(公告)日：2018-07-03

申请号：US14678275

申请日：2015-04-03

Applicant: Siemens Aktiengesellschaft

Inventor： Martin Ott

IPC: G01V3/00 ,  G01R33/48 ,  G01R33/30 ,  G01R33/34 ,  G01R33/385 ,  G01R33/56 ,  G01R33/561

CPC classification number: G01R33/4822 ,  G01R33/30 ,  G01R33/34092 ,  G01R33/3852 ,  G01R33/5608 ,  G01R33/5617

Abstract: For each k-space line, a time period is defined that starts with the application of the RF pulse directly prior to the acquisition of the respective k-space line, and ends at the time point of the echo during the acquisition of the MR data of the respective k-space line. This time period is set shorter for those k-space lines that lie in a central region of k-space than for k-space lines that lie outside of the central region.

公开(公告)号：US10012709B2

公开(公告)日：2018-07-03

申请号：US13958654

申请日：2013-08-05

Applicant: Ovidiu Andronesi ,  Bruce Rosen ,  Peter Caravan ,  Himanshu Bhat

Inventor： Ovidiu Andronesi ,  Bruce Rosen ,  Peter Caravan ,  Himanshu Bhat

IPC: G01V3/00 ,  G01R33/36 ,  G01R33/56 ,  A61B5/055 ,  G01R33/561

CPC classification number: G01R33/36 ,  A61B5/055 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617

Abstract: A system acquires MR imaging data of a portion of patient anatomy associated with proton spin lattice relaxation time in a rotating frame using an RF (Radio Frequency) signal generator configured to generate RF excitation pulses and a magnetic field gradient generator configured to generate anatomical volume select magnetic field gradients for phase encoding and readout RF data acquisition. The RF signal generator and the gradient generator are configured to provide a rotating frame preparation pulse sequence comprising at least one of, (a) a T1 spin lattice relaxation in a rotating frame (T1ρ) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection and (b) a T2 spin-spin relaxation in a rotating frame (T2ρ) preparation pulse sequence of adiabatic pulses comprising modulated RF pulses and modulated magnetic field gradients for slice selection.