公开(公告)号：US09366738B2

公开(公告)日：2016-06-14

申请号：US14840327

申请日：2015-08-31

Applicant: bioProtonics LLC

Inventor： David R. Chase ,  Timothy W. James ,  Kristin M. James

IPC: G01V3/00 ,  G01R33/48 ,  G01R33/54 ,  G01R33/385 ,  A61B5/00 ,  A61B5/055

CPC classification number: G01R33/4818 ,  A61B5/055 ,  A61B5/7207 ,  G01R33/385 ,  G01R33/4833 ,  G01R33/54 ,  G01R33/5616 ,  G01R33/5617

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.

Abstract translation: 所公开的实施例提供了一种用于以分辨率低至几十微米获取MR数据的方法，用于体内诊断和监测病理学，其中精细组织纹理的变化可用作疾病发作和进展的标志。 骨病，肿瘤，神经系统疾病和涉及纤维化生长和/或破坏的疾病都是目标病态。 此外，该技术可以用于需要非常高分辨率表征精细尺度形态的任何生物或物理系统中。 该方法提供了在k空间中快速获取所选择的值，并且以定义的组织体积内的微秒数量级的时间尺度上采集的各个k值的多次连续采集，以及以这种方式的多个测量结果的后续组合 以使SNR最大化。 缩小的采集量以及沿所选方向仅在k空间中的选择值的获取实现了比目前的MRI技术可获得更高的体内分辨率。

公开(公告)号：US20180313925A1

公开(公告)日：2018-11-01

申请号：US16028768

申请日：2018-07-06

Applicant: BIOPROTONICS, LLC

Inventor： Ian Parker ,  David R. Chase ,  Timothy W. James ,  Kristin James

IPC: G01R33/56 ,  G01R33/48 ,  G01R33/483 ,  G01R33/561 ,  G01R33/563 ,  G06T7/00

CPC classification number: G01R33/5601 ,  A61B5/055 ,  G01R33/4818 ,  G01R33/4828 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/56 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5619 ,  G01R33/56341 ,  G06T7/0012 ,  G06T2207/10088

Abstract: A method for identifying the chemical species of various textural elements in a targeted region of tissue wherein a volume of interest (VOI) is selectively excited and a k-encode gradient pulse is applied to induce phase wrap to create a spatial encode for a specific k-value and orientation. The specific k-value is selected based on anticipated texture within the VOI. Multiple sequential samples of the NMR RF signal encoded with the specific k-value are recorded as signal data. The Fourier Transform of the acquired signal data is then taken, wherein for each k-encode, the signal recorded is indicative of the spatial frequency power density at that point in k-space. Each peak in the NMR spectrum is then evaluated, whereby the relative contribution to the texture of tissue in the VOI at a k-value for each chemical species is determined.

公开(公告)号：US20170261584A1

公开(公告)日：2017-09-14

申请号：US15604465

申请日：2017-05-24

Applicant: bioProtonics, LLC

Inventor： Kristin James ,  Timothy W. James

IPC: G01R33/56 ,  G06T7/00 ,  G01R33/561

CPC classification number: G01R33/5601 ,  A61B5/055 ,  G01R33/4818 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/5619 ,  G01R33/56341 ,  G06T7/0012 ,  G06T2207/10088

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

公开(公告)号：US10215827B2

公开(公告)日：2019-02-26

申请号：US16028768

申请日：2018-07-06

Applicant: BIOPROTONICS, LLC

Inventor： Ian Parker ,  David R. Chase ,  Timothy W. James ,  Kristin James

IPC: G01R33/56 ,  G01R33/48 ,  G01R33/483 ,  G01R33/561 ,  G01R33/563 ,  G06T7/00

Abstract: A method for identifying the chemical species of various textural elements in a targeted region of tissue wherein a volume of interest (VOI) is selectively excited and a k-encode gradient pulse is applied to induce phase wrap to create a spatial encode for a specific k-value and orientation. The specific k-value is selected based on anticipated texture within the VOI. Multiple sequential samples of the NMR RF signal encoded with the specific k-value are recorded as signal data. The Fourier Transform of the acquired signal data is then taken, wherein for each k-encode, the signal recorded is indicative of the spatial frequency power density at that point in k-space. Each peak in the NMR spectrum is then evaluated, whereby the relative contribution to the texture of tissue in the VOI at a k-value for each chemical species is determined.

公开(公告)号：US09664760B2

公开(公告)日：2017-05-30

申请号：US15288974

申请日：2016-10-07

Applicant: BIOPROTONICS LLC

Inventor： Kristin M. James ,  Timothy W. James

IPC: G01R33/48 ,  G01R33/50 ,  G01R33/483 ,  G01R33/563

CPC classification number: G01R33/4818 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4088 ,  A61B5/4244 ,  A61B5/4312 ,  A61B5/4504 ,  A61B5/4509 ,  A61B5/7257 ,  A61B5/7264 ,  A61B5/7285 ,  A61B2576/026 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/56341

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.

公开(公告)号：US20170030986A1

公开(公告)日：2017-02-02

申请号：US15288974

申请日：2016-10-07

Applicant: BIOPROTONICS LLC

Inventor： Kristin M. James ,  Timothy W. James

IPC: G01R33/48 ,  G01R33/483 ,  G01R33/563 ,  G01R33/50

CPC classification number: G01R33/4818 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4088 ,  A61B5/4244 ,  A61B5/4312 ,  A61B5/4504 ,  A61B5/4509 ,  A61B5/7257 ,  A61B5/7264 ,  A61B5/7285 ,  A61B2576/026 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/56341

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.

Abstract translation: 所公开的实施例提供了一种用于以分辨率低至几十微米获取MR数据的方法，用于体内诊断和监测病理学，其中精细组织纹理的变化可用作疾病发作和进展的标志。 骨病，肿瘤，神经系统疾病和涉及纤维化生长和/或破坏的疾病都是目标病态。 此外，该技术可以用于需要非常高分辨率表征精细尺度形态的任何生物或物理系统中。 该方法提供在k空间中快速获取所选择的值，并且以定义的组织体积内的微秒数量级的多个连续采集在时间尺度上进行多次连续采集，并且以这种方式的多个测量的后续组合 以使SNR最大化。 缩小的采集量以及沿所选方向仅在k空间中的选择值的获取实现了比目前的MRI技术可获得更高的体内分辨率。

公开(公告)号：US10330763B2

公开(公告)日：2019-06-25

申请号：US16044393

申请日：2018-07-24

Applicant: bioProtonics, LLC

Inventor： Kristin James ,  Timothy W. James

IPC: G01R33/56 ,  G01R33/561 ,  G06T7/00 ,  A61B5/055 ,  G01R33/48 ,  G01R33/483 ,  G01R33/563 ,  A61B5/00 ,  G01R33/50

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

公开(公告)号：US20180329009A1

公开(公告)日：2018-11-15

申请号：US16044393

申请日：2018-07-24

Applicant: bioProtonics, LLC

Inventor： Kristin James ,  Timothy W. James

IPC: G01R33/56 ,  G01R33/561 ,  G06T7/00 ,  G01R33/563 ,  A61B5/055

CPC classification number: G01R33/5601 ,  A61B5/055 ,  A61B5/7203 ,  A61B5/7207 ,  A61B2560/0238 ,  G01R33/4818 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/5619 ,  G01R33/56341 ,  G06T7/0012 ,  G06T2207/10088

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

公开(公告)号：US10061003B2

公开(公告)日：2018-08-28

申请号：US15604465

申请日：2017-05-24

Applicant: bioProtonics, LLC

Inventor： Kristin James ,  Timothy W. James

IPC: G01R33/56 ,  G01R33/561 ,  G06T7/00

CPC classification number: G01R33/5601 ,  A61B5/055 ,  A61B5/7203 ,  A61B5/7207 ,  A61B2560/0238 ,  G01R33/4818 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/50 ,  G01R33/5602 ,  G01R33/5616 ,  G01R33/5617 ,  G01R33/5619 ,  G01R33/56341 ,  G06T7/0012 ,  G06T2207/10088

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of signal at selected values in k-space, with multiple successive acquisitions at individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only signal values at select places in k-space, along selected directions, enables much higher in vivo resolution than is obtainable with current MRI techniques.

公开(公告)号：US09664759B2

公开(公告)日：2017-05-30

申请号：US15167828

申请日：2016-05-27

Applicant: bioProtonics, LLC

Inventor： Kristin M. James ,  Timothy W. James ,  David R. Chase

IPC: G01V3/00 ,  G01R33/48 ,  G01R33/483 ,  G01R33/385 ,  G01R33/381 ,  G01R33/561

CPC classification number: G01R33/4818 ,  A61B5/055 ,  A61B5/4064 ,  A61B5/4082 ,  A61B5/4088 ,  A61B5/4312 ,  A61B5/4504 ,  A61B5/4842 ,  A61B2576/026 ,  G01R33/381 ,  G01R33/385 ,  G01R33/4833 ,  G01R33/4835 ,  G01R33/5616 ,  G01R33/5617

Abstract: The disclosed embodiments provide a method for acquiring MR data at resolutions down to tens of microns for application in in-vivo diagnosis and monitoring of pathology for which changes in fine tissue textures can be used as markers of disease onset and progression. Bone diseases, tumors, neurologic diseases, and diseases involving fibrotic growth and/or destruction are all target pathologies. Further the technique can be used in any biologic or physical system for which very high-resolution characterization of fine scale morphology is needed. The method provides rapid acquisition of selected values in k-space, with multiple successive acquisitions of individual k-values taken on a time scale on the order of microseconds, within a defined tissue volume, and subsequent combination of the multiple measurements in such a way as to maximize SNR. The reduced acquisition volume, and acquisition of only select values in k-space along selected directions, enables much higher in-vivo resolution than is obtainable with current MRI techniques.