公开(公告)号：US08000436B2

公开(公告)日：2011-08-16

申请号：US12080860

申请日：2008-04-07

申请人： Edward J. Seppi ,  John Ford ,  Marcel Marc

发明人： Edward J. Seppi ,  John Ford ,  Marcel Marc

IPC分类号： G01N23/00

CPC分类号： G01V5/005 ,  G01N23/046 ,  G01N2223/419

摘要： A scanning unit for inspecting objects comprises in one example a radiation source, a movable platform to support an object, and a detector positioned to receive radiation after interaction of radiation with the object. The platform is movable at least partially within a cavity defined, at least partially, below at least one of the source or the detector. In another scanning unit, a first conveyor conveys an object to a movable platform, and second and third conveyors convey the object from the platform. The second and third conveyors are at different vertical heights. In another scanning unit, images from an energy sensitive detector and a spatial detector are fused. In a method, scanning parameters during CT scanning are changed and images reconstructed before and after the change. In another method, an object is scanned with X-ray beams having first and second energy distributions, generated by the same X-ray source.

摘要翻译： 用于检查物体的扫描单元在一个示例中包括辐射源，用于支撑物体的可移动平台以及定位成在辐射与物体相互作用之后接收辐射的检测器。 该平台至少部分地在至少部分地在源或检测器中的至少一个之下限定的空腔内移动。 在另一个扫描单元中，第一输送器将物体传送到可移动平台，第二和第三输送机从平台传送物体。 第二和第三输送机处于不同的垂直高度。 在另一个扫描单元中，来自能量敏感检测器和空间检测器的图像被融合。 在一种方法中，CT扫描期间的扫描参数被改变，并且在改变之前和之后重建图像。 在另一种方法中，用具有由相同X射线源产生的第一和第二能量分布的X射线束扫描物体。

公开(公告)号：US07103137B2

公开(公告)日：2006-09-05

申请号：US10202273

申请日：2002-07-24

申请人： Edward J. Seppi ,  Marcel Marc ,  John Ford

发明人： Edward J. Seppi ,  Marcel Marc ,  John Ford

IPC分类号： G01N23/00

CPC分类号： G01V5/005 ,  G01N23/04 ,  G01N2223/423 ,  G01T1/2985

摘要： A scanning unit for identifying contraband within objects, such as cargo containers and luggage, moving through the unit along a first path comprises at least one source of a beam of radiation movable across a second path that is transverse to the first path and extends partially around the first path. A stationary detector transverse to the first path also extends partially around the first path, positioned to detect radiation transmitted through the object during scanning. In one example, a plurality of movable X-ray sources are supported by a semi-circular rail perpendicular to the first path and the detector, which may be a detector array is also semi-circular and perpendicular to the path. A fan beam may also be used. Radiographic images may be obtained and/or computed tomography (“CT”) images may be reconstructed. The images may be analyzed for contraband. Methods of scanning objects are also disclosed.

摘要翻译： 用于识别物体内的违禁品的扫描单元，例如货物集装箱和行李箱，沿着第一路径移动通过该单元包括至少一个辐射源的源，该辐射束可跨越横向于第一路径的第二路径并部分地围绕 第一条路。 横向于第一路径的固定式检测器也部分地围绕第一路径延伸，定位成在扫描期间检测透过物体的辐射。 在一个示例中，多个可移动X射线源由垂直于第一路径的半圆形轨道支撑，并且可以是检测器阵列的检测器阵列也是半圆形的并且垂直于路径。 也可以使用扇形光束。 可以获得放射照相图像和/或计算机断层摄影（“CT”）图像。 图像可能被分析为违禁品。 还公开了扫描对象的方法。

公开(公告)号：US20080205583A1

公开(公告)日：2008-08-28

申请号：US12151362

申请日：2008-05-06

申请人： Edward J. Seppi ,  Marcel Marc ,  John Ford

发明人： Edward J. Seppi ,  Marcel Marc ,  John Ford

IPC分类号： A61B6/00 ,  G01N23/204

CPC分类号： G01V5/005 ,  G01N23/04 ,  G01N2223/423 ,  G01T1/2985

摘要： Systems and methods for the radiation scanning of objects, including large objects such as cargo containers, to identify contraband.

摘要翻译： 用于物体辐射扫描的系统和方法，包括大型物体，如货物集装箱，以识别违禁品。

公开(公告)号：US07369640B2

公开(公告)日：2008-05-06

申请号：US11515479

申请日：2006-09-01

申请人： Edward J. Seppi ,  Marcel Marc ,  John Ford

发明人： Edward J. Seppi ,  Marcel Marc ,  John Ford

IPC分类号： G01N23/00

CPC分类号： G01V5/005 ,  G01N23/04 ,  G01N2223/423 ,  G01T1/2985

摘要： In one example, a scanning unit for examining contents of a cargo container is disclosed comprising a first path through the scanning unit for transport of a cargo container and one or more sources of respective beams of radiation. At least one of the one or more sources are movable across a second path transverse to the first path. The second path extends partially around the first path. The scanning unit further comprises a detector extending partially around the first path. The detector is positioned to detect radiation interacting with the cargo container during scanning, such as radiation transmitted through the container. The at least one source and the detector are positioned so that the cargo container is transportable along the first path, between the source and the detector. A transport system may be provided to convey the object through the scanning unit, along the first path.

摘要翻译： 在一个示例中，公开了一种用于检查货物集装箱的内容物的扫描单元，其包括通过扫描单元的第一路径，用于运输货物集装箱和一个或多个相应的辐射源。 所述一个或多个源中的至少一个源可横跨第一路径的第二路径移动。 第二路径部分围绕第一路径延伸。 扫描单元还包括部分围绕第一路径延伸的检测器。 检测器被定位成在扫描期间检测与货物集装箱相互作用的辐射，例如透过容器的辐射。 所述至少一个源和检测器被定位成使得货物容器能够沿着源和检测器之间的第一路径传送。 可以提供传送系统以沿着第一路径通过扫描单元传送物体。

公开(公告)号：US07672422B2

公开(公告)日：2010-03-02

申请号：US12151362

申请日：2008-05-06

申请人： Edward J. Seppi ,  Marcel Marc ,  John Ford

发明人： Edward J. Seppi ,  Marcel Marc ,  John Ford

IPC分类号： G01N23/00

CPC分类号： G01V5/005 ,  G01N23/04 ,  G01N2223/423 ,  G01T1/2985

摘要： Systems and methods for the radiation scanning of objects, including large objects such as cargo containers, to identify contraband.

摘要翻译： 用于物体辐射扫描的系统和方法，包括大型物体，如货物集装箱，以识别违禁品。

公开(公告)号：US07356115B2

公开(公告)日：2008-04-08

申请号：US10310060

申请日：2002-12-04

申请人： John Ford ,  Edward J. Seppi

发明人： John Ford ,  Edward J. Seppi

IPC分类号： G01N23/04

CPC分类号： G01V5/005 ,  G01N23/046 ,  G01N2223/419

摘要： A scanning unit for inspecting objects comprises in one embodiment a radiation source to emit a beam of radiation, a rotatable platform to support an object for inspection by the beam of radiation and a detector positioned to receive radiation after interaction of the beam with the object. At least one of the platform, the source and the detector may be moved in a first direction, such as vertically. The object may be scanned while being rotated and moved to generate volumetric computed tomographic images. The rotational and movement of the platform and the object may also be indexed. The beam of radiation may be a horizontally extending cone beam or a fan beam. The detector may extend horizontally, as well. The rotational and/or vertical position of the platform may be used to direct the object along one of multiple exit paths. The scanning unit may provide a vertically extending radiation beam and a vertically extending detector to conduct line scanning. The radiation source may be a source of X-rays, for example. Multiple sources may be provided. The scanning unit may also provide a pencil beam and a movable detector to detect scattered radiation. The pencil beam may induce fission in fissionable material in the object. The source of the pencil beam may be a source of neutrons or gamma rays, for example. Stimulated emissions, such as nuclear resonance fluorescence, may also be detected.

摘要翻译： 用于检查物体的扫描单元包括在一个实施例中用于发射辐射束的辐射源，用于支撑被辐射束检查的物体的可旋转平台以及定位成在光束与物体相互作用之后接收辐射的探测器。 平台，源和检测器中的至少一个可以在诸如垂直的第一方向上移动。 可以在旋转和移动物体的同时扫描物体以产生体积计算机断层图像。 平台和物体的旋转和移动也可以被索引。 辐射束可以是水平延伸的锥形束或扇形束。 检测器也可以水平延伸。 平台的旋转和/或垂直位置可以用于沿着多个出口路径之一引导物体。 扫描单元可以提供垂直延伸的辐射束和垂直延伸的检测器来进行扫描。 例如，辐射源可以是X射线源。 可以提供多个来源。 扫描单元还可以提供笔形束和可移动检测器来检测散射的辐射。 铅笔光束可能在物体中的可裂变材料中引发裂变。 例如，铅笔光束的源可以是中子或伽马射线的源。 刺激的排放物，如核共振荧光，也可能被检测。

公开(公告)号：US20070003003A1

公开(公告)日：2007-01-04

申请号：US11515479

申请日：2006-09-01

申请人： Edward Seppi ,  Marcel Marc ,  John Ford

发明人： Edward Seppi ,  Marcel Marc ,  John Ford

IPC分类号： A61B6/00 ,  G01N23/00 ,  G21K1/12 ,  H05G1/60

CPC分类号： G01V5/005 ,  G01N23/04 ,  G01N2223/423 ,  G01T1/2985

摘要： In one example, a scanning unit for examining contents of a cargo container is disclosed comprising a first path through the scanning unit for transport of a cargo container and one or more sources of respective beams of radiation. At least one of the one or more sources are movable across a second path transverse to the first path. The second path extends partially around the first path. The scanning unit further comprises a detector extending partially around the first path. The detector is positioned to detect radiation interacting with the cargo container during scanning, such as radiation transmitted through the container. The at least one source and the detector are positioned so that the cargo container is transportable along the first path, between the source and the detector. A transport system may be provided to convey the object through the scanning unit, along the first path.

摘要翻译： 在一个示例中，公开了一种用于检查货物集装箱的内容物的扫描单元，其包括通过扫描单元的第一路径，用于运输货物集装箱和一个或多个相应的辐射源。 所述一个或多个源中的至少一个源可横跨第一路径的第二路径移动。 第二路径部分围绕第一路径延伸。 扫描单元还包括部分围绕第一路径延伸的检测器。 检测器被定位成在扫描期间检测与货物集装箱相互作用的辐射，例如透过容器的辐射。 所述至少一个源和检测器被定位成使得货物容器能够沿着源和检测器之间的第一路径传送。 可以提供传送系统以沿着第一路径通过扫描单元传送物体。

公开(公告)号：US20090067575A1

公开(公告)日：2009-03-12

申请号：US12080860

申请日：2008-04-07

申请人： Edward E. Seppi ,  John Ford ,  Marcel Marc

发明人： Edward E. Seppi ,  John Ford ,  Marcel Marc

IPC分类号： G01N23/04

CPC分类号： G01V5/005 ,  G01N23/046 ,  G01N2223/419

摘要： A scanning unit for inspecting objects comprises in one example a radiation source, a movable platform to support an object, and a detector positioned to receive radiation after interaction of radiation with the object. The platform is movable at least partially within a cavity defined, at least partially, below at least one of the source or the detector. In another scanning unit, a first conveyor conveys an object to a movable platform, and second and third conveyors convey the object from the platform. The second and third conveyors are at different vertical heights. In another scanning unit, images from an energy sensitive detector and a spatial detector are fused. In a method, scanning parameters during CT scanning are changed and images reconstructed before and after the change. In another method, an object is scanned with X-ray beams having first and second energy distributions, generated by the same X-ray source.

摘要翻译： 用于检查物体的扫描单元在一个示例中包括辐射源，用于支撑物体的可移动平台以及定位成在辐射与物体相互作用之后接收辐射的检测器。 该平台至少部分地在至少部分地在源或检测器中的至少一个之下限定的空腔内移动。 在另一个扫描单元中，第一输送器将物体传送到可移动平台，第二和第三输送机从平台传送物体。 第二和第三输送机处于不同的垂直高度。 在另一个扫描单元中，来自能量敏感检测器和空间检测器的图像被融合。 在一种方法中，CT扫描期间的扫描参数被改变，并且在改变之前和之后重建图像。 在另一种方法中，用具有由相同X射线源产生的第一和第二能量分布的X射线束扫描物体。

公开(公告)号：US20100087428A1

公开(公告)日：2010-04-08

申请号：US12550860

申请日：2009-08-31

申请人： Mushtaq Mulla ,  Derek Edward John ,  Richard John Hamlyn ,  Sasha Louise Garrett ,  Basil Hartzoulakis ,  David Madge ,  John Ford

发明人： Mushtaq Mulla ,  Derek Edward John ,  Richard John Hamlyn ,  Sasha Louise Garrett ,  Basil Hartzoulakis ,  David Madge ,  John Ford

IPC分类号： A61K31/415 ,  C07D231/04 ,  C07D233/66 ,  C07D213/62 ,  C07D265/36 ,  A61K31/4164 ,  A61K31/44 ,  A61K31/538 ,  A61P19/02 ,  A61P17/06 ,  A61P37/00

CPC分类号： C07C311/21 ,  C07C311/46 ,  C07C317/32 ,  C07C317/40 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07D207/12 ,  C07D209/08 ,  C07D211/16 ,  C07D211/34 ,  C07D211/44 ,  C07D213/36 ,  C07D213/40 ,  C07D213/71 ,  C07D231/12 ,  C07D231/18 ,  C07D231/56 ,  C07D233/61 ,  C07D233/64 ,  C07D233/84 ,  C07D265/30 ,  C07D265/36 ,  C07D271/08 ,  C07D277/28 ,  C07D277/36 ,  C07D277/46 ,  C07D285/12 ,  C07D285/135 ,  C07D307/79 ,  C07D311/70 ,  C07D317/62 ,  C07D319/18 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

摘要： The present invention provides a compound of formula (I) or its salts or pharmaceutically acceptable derivatives thereof wherein; X1 is selected from a group consisting of CH2, C(═O), C(═NH), NC(═O), R1 is selected from the group consisting of optionally substituted arylalkyl, and optionally substituted heteroarylalkyl R2 is selected from the group consisting of optionally substituted alkyl, optionally substituted aryl or heteroaryl or NR24R25 R3 is selected from the group consisting of hydrogen, halogen, hydroxyl, alkoxy, aryloxy, optionally substituted alkyl, optionally substituted amino, optionally substituted amino sulfonyl or nitrile; R4 is selected from the group consisting of optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted acyl, optionally substituted sulfonyl, optionally substituted sulfamoyl, optionally substituted aryl, optionally substituted arylalkyl, and optionally substituted heteroaryl R5 may be hydrogen, an optionally substituted alkyl, preferably CH3 or, NR4R5 may form an optionally substituted saturated or partially saturated 4-7 membered ring with the general formula (II). Wherein; X2 is C(═O), CH2, CH(R6) or C(R6)(R6), X3 is CH2, CH(R7), C(R7)(R7), NH, N(R8), O or S Each R6 independently represents optionally substituted amino, optionally substituted amino carbonyl, hydroxyl, optionally substituted acyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalky, optionally substituted aryl or optionally substituted heteroaryl; Each R7 independently represents optionally substituted amino, optionally substituted amino carbonyl, hydroxyl, optionally substituted acyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalky, optionally substituted aryl or optionally substituted hetero aryl R8 is optionally substituted acyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl; R24 and R25 are the same or different and each represents hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted arylalkyl, optionally substituted aryl or optionally substituted heteroaryl, n=1 or 2 m=1, 2 or 3 With the proviso that when X1 is C═O and R5 is H then R4 is not: Or Or Where R4a, R5a and R6a are each independently H, C1-6alkyl, aryl, heteroaryl, cycloalkyl, or aryl-C1-6alkyl; R10a is H or C1-6alkyl; and R11a is C1-6alkyl or aryl-C1-6alkyl and when X1 is C═O or CH2 and R5 is H then R4 is not: Where q is 0 to 5, R3b is H, OH or alkoxy and R4b is NH2, phenyl or a C3-10 heterocycle. The compounds are useful as potassium ion channel inhibitors.

公开(公告)号：US20070222433A1

公开(公告)日：2007-09-27

申请号：US11386449

申请日：2006-03-21

申请人： Timothy Tiernan ,  John Ford

发明人： Timothy Tiernan ,  John Ford

IPC分类号： H01L41/00 ,  G01B7/30 ,  G01V3/00

CPC分类号： G01R33/3415 ,  A61B5/04005 ,  A61B5/04007 ,  A61B5/062 ,  A61B5/6852 ,  A61B5/6853 ,  A61B5/687 ,  A61B2562/043 ,  G01R33/286 ,  G01R33/323 ,  G01R33/34084 ,  G01R33/3806 ,  G01R33/5617

摘要： The present invention generally provides improved devices, systems, and methods for measuring materials with NMR and/or MRI. Exemplary embodiments provide a sensor array for NMR mapping of the material. For example tissue can be measured with the sensor array mounted on a probe body having a distal portion which can be inserted through a minimally invasive aperture. While many tissues can be measured and/or diagnosed, one exemplary embodiment includes a probe adapted for insertion into a lumen of a blood vessel. The sensor array can provide improved spatial resolution of tissue and/or tissue structures positioned near the sensor array to diagnose potentially life threatening diseases, for example a fibrous cap covering a vulnerable plaque. In specific embodiments, the sensors are attached to an expandable member, for example a balloon, which can be inflated to urge the probe sensors radially outward to position the sensors near the tissue structures.

摘要翻译： 本发明通常提供用NMR和/或MRI测量材料的改进的装置，系统和方法。 示例性实施例提供用于材料的NMR映射的传感器阵列。 例如，可以用传感器阵列测量组织，传感器阵列安装在具有远端部分的探针主体上，该远端部分可插入通过微创孔径。 虽然可以测量和/或诊断许多组织，但是一个示例性实施例包括适于插入血管内腔的探针。 传感器阵列可以提供设置在传感器阵列附近的组织和/或组织结构的改进的空间分辨率，以诊断潜在的威胁生命的疾病，例如覆盖易损斑块的纤维帽。 在具体实施例中，传感器附接到可膨胀构件，例如球囊，其可以被膨胀以将探针传感器径向向外推动以将传感器定位在组织结构附近。