-
公开(公告)号：US09708283B2
公开(公告)日：2017-07-18
申请号：US13881599
申请日：2011-11-01
Applicant: Ofir Moreno
Inventor： Ofir Moreno
IPC: C07D311/58 , A61K31/353 , A61K47/40 , A61P35/00 , A61K31/337 , A61K31/555 , A61K33/24 , A61K45/06 , A61K9/00 , A61K9/51
CPC classification number: C07D311/58 , A61K9/0019 , A61K9/5161 , A61K31/337 , A61K31/353 , A61K31/555 , A61K33/24 , A61K45/06 , A61K47/40 , A61K2300/00
Abstract: Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions. In specific instances, provided herein are intravenous compositions and therapies.
-
2.发明申请COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE ASSOCIATED WITH TRP-P8 EXPRESSION 有权治疗与TRP-P8表达相关疾病的组合物和方法公开(公告)号：US20120094977A1
公开(公告)日：2012-04-19
申请号：US13115893
申请日：2011-05-25
Applicant: Sateesh K. Natarajan , Ofir Moreno , Thomas J. Graddis , David F. Duncan , Reiner Laus , Feng Chen
Inventor： Sateesh K. Natarajan , Ofir Moreno , Thomas J. Graddis , David F. Duncan , Reiner Laus , Feng Chen
IPC: A61K31/164 , A61K31/498 , A61K31/341 , A61K31/4045 , A61K31/277 , C12Q1/02 , A61K31/5375 , A61K31/54 , A61K31/55 , A61P35/00 , C12N5/02 , A61K31/166 , A61K31/37
CPC classification number: C07C233/60 , A61K31/498 , A61K31/517 , A61K45/06 , C07C233/58 , C07C243/36 , C07C243/38 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/06 , C07D207/09 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/20 , C07D209/48 , C07D211/06 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D223/04 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D241/54 , C07D251/54 , C07D263/34 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D311/16 , C07D317/66 , C07D333/34 , C07D401/04 , C07D403/14 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/5011 , G01N33/6872 , G01N2500/10 , A61K2300/00
Abstract: Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
Abstract translation: 提供的是小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物以及用于鉴定和表征新型小分子Trp-p8调节剂的方法和方法 降低Trp-p8表达细胞的生存力和/或抑制Trp-p8表达细胞的生长，用于激活Trp-p8介导的阳离子流入的方法，用于刺激细胞凋亡和/或坏死的方法以及用于治疗疾病的相关方法，包括癌症如肺，乳腺 ，结肠癌和/或前列腺癌以及与Trp-p8表达相关的其它疾病，例如良性前列腺增生。
-
公开(公告)号：US07019019B2
公开(公告)日：2006-03-28
申请号：US10740946
申请日：2003-12-18
Applicant: David F. Duncan , L. Josue Alfaro-Lopez , Mallareddy Komandla , Odile Esther Levy , Ofir Moreno , Joseph E. Semple , Amir P. Tamiz
Inventor： David F. Duncan , L. Josue Alfaro-Lopez , Mallareddy Komandla , Odile Esther Levy , Ofir Moreno , Joseph E. Semple , Amir P. Tamiz
IPC: A61K31/44 , A61K31/425 , A61K31/38 , C07D333/22 , C07D211/72
CPC classification number: C07D231/56 , C07D333/38
Abstract: The present invention provides matriptase inhibitors and compositions thereof useful for treating cancer. Martripase is a trypsin-like serine protease active in the development of cancerous conditions, such as tumors and metastasis of cancer.
Abstract translation: 本发明提供了可用于治疗癌症的基质酶抑制剂及其组合物。 枸杞子是一种胰蛋白酶样的丝氨酸蛋白酶，可在肿瘤和肿瘤转移等癌症病症中起积极作用。
-
公开(公告)号：US08618155B2
公开(公告)日：2013-12-31
申请号：US12853202
申请日：2010-08-09
Applicant: Ofir Moreno , Sateesh Natarajan , David F. Duncan
Inventor： Ofir Moreno , Sateesh Natarajan , David F. Duncan
IPC: A61K31/415 , A61K31/4155
CPC classification number: C07C233/60 , A61K31/015 , A61K31/095 , A61K31/10 , A61K31/16 , A61K31/165 , A61K31/4155 , A61K31/4166 , A61K31/4184 , A61K31/4188 , C07C233/62 , C07C237/04 , C07C237/10 , C07C237/42 , C07C237/44 , C07C323/40 , C07C323/63 , C07C2601/14 , C07D231/40 , C07D235/26 , C07D401/12 , C07D403/04 , C07D405/04
Abstract: Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
-
5.发明申请公开(公告)号：US20130273177A1
公开(公告)日：2013-10-17
申请号：US13881599
申请日：2011-11-01
Applicant: Ofir Moreno
Inventor： Ofir Moreno
IPC: C07D311/58 , A61K31/353 , A61K45/06
CPC classification number: C07D311/58 , A61K9/0019 , A61K9/5161 , A61K31/337 , A61K31/353 , A61K31/555 , A61K33/24 , A61K45/06 , A61K47/40 , A61K2300/00
Abstract: Provided herein is a pharmaceutical composition comprising an isoflavonoid derivative and a cyclodextrin. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions. In specific instances, provided herein are intravenous compositions and therapies.
Abstract translation: 本文提供包含异黄酮衍生物和环糊精的药物组合物。 本文还提供了通过施用这样的组合物治疗癌症，致敏癌细胞和诱导癌细胞凋亡的方法。 在具体情况下，本文提供静脉内组合物和疗法。
-
Patent Agency Ranking
6.发明授权Compositions and methods for the treatment of disease associated with Trp-p8 expression 有权用于治疗与Trp-p8表达相关的疾病的组合物和方法公开(公告)号：US08362264B2
公开(公告)日：2013-01-29
申请号：US10923413
申请日：2004-08-20
Applicant: Sateesh K. Natarajan , Ofir Moreno , Thomas J. Graddis , David F. Duncan , Reiner Laus , Feng Chen
Inventor： Sateesh K. Natarajan , Ofir Moreno , Thomas J. Graddis , David F. Duncan , Reiner Laus , Feng Chen
IPC: C07D211/70 , C07C257/00 , A61K31/155
CPC classification number: C07C233/60 , A61K31/498 , A61K31/517 , A61K45/06 , C07C233/58 , C07C243/36 , C07C243/38 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/06 , C07D207/09 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/20 , C07D209/48 , C07D211/06 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D223/04 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D241/54 , C07D251/54 , C07D263/34 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D311/16 , C07D317/66 , C07D333/34 , C07D401/04 , C07D403/14 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/5011 , G01N33/6872 , G01N2500/10 , A61K2300/00
Abstract: Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
Abstract translation: 提供的是小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物以及用于鉴定和表征新型小分子Trp-p8调节剂的方法和方法 降低Trp-p8表达细胞的生存力和/或抑制Trp-p8表达细胞的生长，用于激活Trp-p8介导的阳离子流入的方法，用于刺激细胞凋亡和/或坏死的方法以及用于治疗疾病的相关方法，包括癌症如肺，乳腺 ，结肠癌和/或前列腺癌以及与Trp-p8表达相关的其它疾病，例如良性前列腺增生。
-
公开(公告)号：US20140234295A1
公开(公告)日：2014-08-21
申请号：US13881609
申请日：2011-11-01
Applicant: George Jeoffreys , Alison Johnson , Andrew Heaton , Ofir Moreno
Inventor： George Jeoffreys , Alison Johnson , Andrew Heaton , Ofir Moreno
IPC: C07D311/58 , A61K45/06 , A61K31/353
CPC classification number: C07D311/58 , A61K9/0019 , A61K9/5161 , A61K31/337 , A61K31/353 , A61K31/555 , A61K33/24 , A61K45/06 , A61K47/40 , A61K2300/00
Abstract: Provided herein is a pharmaceutical composition comprising at least one isoflavonoid. Also provided herein are methods of treating cancer, sensitizing cancer cells, and inducing apoptosis in cancer cells by administering such compositions.
Abstract translation: 本文提供了包含至少一种异黄酮的药物组合物。 本文还提供了通过施用这样的组合物治疗癌症，致敏癌细胞和诱导癌细胞凋亡的方法。
-
8.发明授权Compositions and methods for the treatment of disease associated with TRP-P8 expression 有权用于治疗与TRP-P8表达相关的疾病的组合物和方法公开(公告)号：US08389730B2
公开(公告)日：2013-03-05
申请号：US13115893
申请日：2011-05-25
Applicant: Sateesh K. Natarajan , Ofir Moreno , Thomas J. Graddis , David F. Duncan , Reiner Laus , Feng Chen
Inventor： Sateesh K. Natarajan , Ofir Moreno , Thomas J. Graddis , David F. Duncan , Reiner Laus , Feng Chen
IPC: A61K31/445 , C07D211/30
CPC classification number: C07C233/60 , A61K31/498 , A61K31/517 , A61K45/06 , C07C233/58 , C07C243/36 , C07C243/38 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/06 , C07D207/09 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/20 , C07D209/48 , C07D211/06 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D223/04 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D241/54 , C07D251/54 , C07D263/34 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D311/16 , C07D317/66 , C07D333/34 , C07D401/04 , C07D403/14 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/5011 , G01N33/6872 , G01N2500/10 , A61K2300/00
Abstract: Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
Abstract translation: 提供的是小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物以及用于鉴定和表征新型小分子Trp-p8调节剂的方法和方法 降低Trp-p8表达细胞的生存力和/或抑制Trp-p8表达细胞的生长，用于激活Trp-p8介导的阳离子流入的方法，用于刺激细胞凋亡和/或坏死的方法以及用于治疗疾病的相关方法，包括癌症如肺，乳腺 ，结肠癌和/或前列腺癌以及与Trp-p8表达相关的其它疾病，例如良性前列腺增生。
-
公开(公告)号：US20070232603A1
公开(公告)日：2007-10-04
申请号：US11707546
申请日：2007-02-15
Applicant: Ofir Moreno , Sateesh Natarajan , David Duncan
Inventor： Ofir Moreno , Sateesh Natarajan , David Duncan
IPC: A61K31/5377 , A61K31/496 , A61K31/416 , A61K31/4184 , A61K31/415 , A61K31/16 , C07D413/02 , C07D403/02
CPC classification number: C07C237/04 , C07C233/60 , C07C233/62 , C07C237/10 , C07C237/42 , C07C237/44 , C07C323/40 , C07C323/63 , C07C2601/14 , C07D231/40 , C07D235/26 , C07D401/12 , C07D403/04 , C07D405/04
Abstract: Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
Abstract translation: 提供的是小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物以及用于鉴定和表征新型小分子Trp-p8调节剂的方法和方法 降低Trp-p8表达细胞的生存力和/或抑制Trp-p8表达细胞的生长，用于激活Trp-p8介导的阳离子流入的方法，用于刺激细胞凋亡和/或坏死的方法以及用于治疗疾病的相关方法，包括癌症如肺，乳腺 ，结肠癌和/或前列腺癌以及与Trp-p8表达相关的其它疾病，例如良性前列腺增生。
-
10.发明申请Compositions and methods for the treatment of disease associated with Trp-p8 expression 有权用于治疗与Trp-p8表达相关的疾病的组合物和方法公开(公告)号：US20050054651A1
公开(公告)日：2005-03-10
申请号：US10923413
申请日：2004-08-20
Applicant: Sateesh Natarajan , Ofir Moreno , Thomas Graddis , David Duncan , Reiner Laus , Feng Chen
Inventor： Sateesh Natarajan , Ofir Moreno , Thomas Graddis , David Duncan , Reiner Laus , Feng Chen
IPC: A61K31/498 , A61K31/517 , A61K45/06 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07D207/06 , C07D207/09 , C07D207/32 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/20 , C07D209/48 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D251/54 , C07D263/34 , C07D263/56 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/26 , C07D307/52 , C07D317/66 , C07D333/34 , C07D401/04 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/68
CPC classification number: C07C233/60 , A61K31/498 , A61K31/517 , A61K45/06 , C07C233/58 , C07C243/36 , C07C243/38 , C07C311/20 , C07C311/37 , C07C323/40 , C07C323/44 , C07C333/06 , C07C2601/14 , C07C2601/18 , C07C2602/42 , C07D207/06 , C07D207/09 , C07D207/325 , C07D209/08 , C07D209/14 , C07D209/16 , C07D209/20 , C07D209/48 , C07D211/06 , C07D213/40 , C07D215/04 , C07D215/08 , C07D215/46 , C07D217/06 , C07D223/04 , C07D231/12 , C07D231/14 , C07D231/56 , C07D235/18 , C07D235/26 , C07D239/42 , C07D241/18 , C07D241/44 , C07D241/54 , C07D251/54 , C07D263/34 , C07D263/57 , C07D279/12 , C07D295/096 , C07D295/135 , C07D295/155 , C07D295/26 , C07D307/52 , C07D311/16 , C07D317/66 , C07D333/34 , C07D401/04 , C07D403/14 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04 , C07D493/08 , C07D495/04 , C07D513/04 , G01N33/5011 , G01N33/6872 , G01N2500/10 , A61K2300/00
Abstract: Provided are small-molecule Trp-p8 modulators, including Trp-p8 agonists and Trp-p8 antagonists, and compositions comprising small-molecule Trp-p8 agonists as well as methods for identifying and characterizing novel small-molecule Trp-p8 modulators and methods for decreasing viability and/or inhibiting growth of Trp-p8 expressing cells, methods for activating Trp-p8-mediated cation influx, methods for stimulating apoptosis and/or necrosis, and related methods for the treatment of diseases, including cancers such as lung, breast, colon, and/or prostate cancers as well as other diseases, such as benign prostatic hyperplasia, that are associated with Trp-p8 expression.
Abstract translation: 提供的是小分子Trp-p8调节剂，包括Trp-p8激动剂和Trp-p8拮抗剂，以及包含小分子Trp-p8激动剂的组合物以及用于鉴定和表征新型小分子Trp-p8调节剂的方法和方法 降低Trp-p8表达细胞的生存力和/或抑制Trp-p8表达细胞的生长，用于激活Trp-p8介导的阳离子流入的方法，用于刺激细胞凋亡和/或坏死的方法以及用于治疗疾病的相关方法，包括癌症如肺，乳腺 ，结肠癌和/或前列腺癌以及与Trp-p8表达相关的其它疾病，例如良性前列腺增生。
-
-
-
-
-
-
-
-
-
Search Results
17
records
(took 0.022 seconds)
