公开(公告)号：US07262211B2

公开(公告)日：2007-08-28

申请号：US10309781

申请日：2002-12-04

Applicant: Amir P. Tamiz ,  L. Josue Alfaro-Lopez ,  Odile Esther Levy ,  Joseph Edward Semple

Inventor： Amir P. Tamiz ,  L. Josue Alfaro-Lopez ,  Odile Esther Levy ,  Joseph Edward Semple

IPC: A61K31/4412 ,  C07D211/04

CPC classification number: C07D213/76 ,  A61K38/00 ,  C07D241/20 ,  C07D405/12 ,  C07D471/04 ,  C07D513/04 ,  C07K5/06139

Abstract: Novel compounds having activity as non-covalent inhibitors of urokinase and having activity in reducing or inhibiting blood vessel formation are provided. These compounds have at a group having a guanidino moiety or derivative thereof. These compounds are useful in vitro for monitoring plasminogen activator levels and in vivo in treatment of conditions which are ameliorated by inhibition of or decreased activity of urokinase and in treating pathologic conditions wherein blood vessel formation is related to a pathologic condition.

Abstract translation: 提供了具有作为尿激酶非共价抑制剂的活性并具有减少或抑制血管形成活性的新型化合物。 这些化合物在具有胍基部分或其衍生物的基团中具有。 这些化合物在体外可用于监测纤溶酶原激活物水平和体内治疗通过抑制或降低尿激酶活性和改善血管形成与病理状况相关的病理状况而改善的病症。

公开(公告)号：US07019019B2

公开(公告)日：2006-03-28

申请号：US10740946

申请日：2003-12-18

Applicant: David F. Duncan ,  L. Josue Alfaro-Lopez ,  Mallareddy Komandla ,  Odile Esther Levy ,  Ofir Moreno ,  Joseph E. Semple ,  Amir P. Tamiz

Inventor： David F. Duncan ,  L. Josue Alfaro-Lopez ,  Mallareddy Komandla ,  Odile Esther Levy ,  Ofir Moreno ,  Joseph E. Semple ,  Amir P. Tamiz

IPC: A61K31/44 ,  A61K31/425 ,  A61K31/38 ,  C07D333/22 ,  C07D211/72

CPC classification number: C07D231/56 ,  C07D333/38

Abstract: The present invention provides matriptase inhibitors and compositions thereof useful for treating cancer. Martripase is a trypsin-like serine protease active in the development of cancerous conditions, such as tumors and metastasis of cancer.

Abstract translation: 本发明提供了可用于治疗癌症的基质酶抑制剂及其组合物。 枸杞子是一种胰蛋白酶样的丝氨酸蛋白酶，可在肿瘤和肿瘤转移等癌症病症中起积极作用。