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公开(公告)号：US20160124201A1
公开(公告)日：2016-05-05
申请号：US14924435
申请日：2015-10-27
Applicant: OLYMPUS CORPORATION
Inventor： Yu KIKUCHI
CPC classification number: G02B21/0048 , G02B21/16
Abstract: A light sheet illumination microscope includes a detection optical system and an illumination optical system. The illumination optical system includes a first optical element for forming a sheet-shaped illumination beam that travels in a first direction and that has a width in a second direction that is perpendicular to both the optical axis of the detection optical system and the first direction in a specimen, and a scanner that relatively scans the specimen with the sheet-shaped illumination beam in the second direction.
Abstract translation: 光照片显微镜包括检测光学系统和照明光学系统。 照明光学系统包括：第一光学元件，用于形成沿第一方向行进的片状照明光束，并且具有与检测光学系统的光轴和第一方向垂直的第二方向的宽度 样本和扫描仪，其沿着第二方向与片状照明光束相对地扫描样本。
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公开(公告)号：US20150198796A1
公开(公告)日：2015-07-16
申请号：US14546910
申请日：2014-11-18
Applicant: OLYMPUS CORPORATION
Inventor： Yu KIKUCHI
CPC classification number: G02B21/0076 , G01N21/645 , G01N21/6456 , G01N21/6458 , G02B7/16 , G02B21/12 , G02B21/16 , G02B21/248 , G02B27/1006 , G02B27/141
Abstract: A microscope is a microscope that switches an observation method between the bright-field observation and the fluorescence observation. The microscope includes an objective that irradiates a sample with excitation light and converts fluorescence from the sample into a parallel light flux, a beam splitter that splits fluorescence and excitation light from each other, and a collecting lens that is arranged in such a manner that it is freely set in and removed from an optical path between the beam splitter and the objective, that has a positive power, and that is set in the optical path for fluorescence observation and is removed from the optical path for bright-field observation.
Abstract translation: 显微镜是在明场观察和荧光观察之间切换观察方法的显微镜。 显微镜包括用激发光照射样品并将样品中的荧光转换为平行光束的目标，将荧光和激发光彼此分离的分束器和以这样的方式布置的收集透镜： 可自由地设置在分束器和物镜之间的光路上，并且具有正光焦度，并被设置在用于荧光观察的光路中，并从光场观察光路中去除。
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公开(公告)号：US20160306154A1
公开(公告)日：2016-10-20
申请号：US15094847
申请日：2016-04-08
Applicant: OLYMPUS CORPORATION
Inventor： Yoshihito IGUCHI , Yu KIKUCHI
CPC classification number: G02B21/06 , G02B21/0032 , G02B21/0076 , G02B21/16 , G02B21/367
Abstract: A light sheet illumination microscope includes an illumination optical system configured to illuminate a sample from a direction substantially perpendicular to an optical axis of a detection optical system. The illumination optical system includes a first optical element configured to convert light emitted from a light source into a light sheet that forms an illumination area having a sheet shape substantially perpendicular to the optical axis of the detection optical system when the sample is irradiated with the light sheet. The illumination optical system further includes a second optical element that configured to act on the light emitted from the light source such that the light sheet is converged, diverged or diffracted in a width direction of the light sheet.
Abstract translation: 照明照明显微镜包括照明光学系统，其配置为从基本上垂直于检测光学系统的光轴的方向照射样品。 照明光学系统包括：第一光学元件，被配置为将光源发射的光转换成光片，所述光片形成具有基本垂直于检测光学系统的光轴的片状的照明区域， 片。 照明光学系统还包括第二光学元件，其被配置为作用于从光源发射的光，使得光片在光片的宽度方向上会聚，发散或衍射。
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公开(公告)号：US20160241758A1
公开(公告)日：2016-08-18
申请号：US15041330
申请日：2016-02-11
Applicant: OLYMPUS CORPORATION
Inventor： Masahito DOHI , Yu KIKUCHI
CPC classification number: H04N5/2256 , G02B21/16 , G02B21/361
Abstract: An object of the present invention is to obtain clear images when observing a specimen at different positions in the optical-axis direction of a detection optical system, using the sheet illumination. A fluorescence microscope of the present invention includes a sheet-illumination optical system that causes sheet-like excitation light along a plane of incidence to be incident on a specimen; an image-acquisition optical system that includes an objective lens having an optical axis intersecting the plane of incidence and that images fluorescence collected by the objective lens to obtain a fluorescence image; a driving part that moves the specimen in the optical-axis direction of the objective lens; and a positional-shift correction unit that, when a focus position of the image-acquisition optical system relative to an illumination position of the excitation light changes due to movement of the specimen in the optical-axis direction by the driving part, corrects a positional shift between the illumination position of the excitation light and the focus position of the image-acquisition optical system.
Abstract translation: 本发明的目的在于，使用片材照明，在检测光学系统的光轴方向上的不同位置观察样本时获得清晰的图像。 本发明的荧光显微镜包括使沿着入射面的片状激发光入射到试样上的片状照明光学系统; 图像采集光学系统，包括具有与入射平面相交的光轴的物镜，以及由物镜收集的图像以获得荧光图像; 驱动部，使所述检体沿所述物镜的光轴方向移动; 以及位置偏移校正单元，当所述摄像光学系统的相对于所述激发光的照明位置的焦点位置由于所述驱动部分的所述样本在光轴方向上的移动而改变时，校正位置 激发光的照明位置与摄像光学系统的焦点位置之间的偏移。
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