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公开(公告)号：US11859022B2
公开(公告)日：2024-01-02
申请号：US16663830
申请日：2019-10-25
发明人： Rong Guan , Michael D. Gagnon , Nikita Iltchenko , Yefim Brun , Laurie A. Howe
CPC分类号： C08B37/0009 , C12N9/1048 , C12P19/04 , C12P19/18
摘要： Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising an alpha-1,3-glucan ether or ester compound, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in various applications.
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公开(公告)号：US20230235096A1
公开(公告)日：2023-07-27
申请号：US17865904
申请日：2022-07-15
发明人： Rakesh Nambiar , Rong Guan , Qiong Cheng , Robert Dicosimo , Jayme L. Paullin , Yuanfeng Liang , Charles R. Powley , Yefim Brun
CPC分类号： C08B37/0021 , C12P19/08 , C11D3/222 , C08L5/02
摘要： Compositions are disclosed herein comprising dextran that comprises (i) 87-93 wt % glucose linked at positions 1 and 6; (ii) 0.1-1.2 wt % glucose linked at positions 1 and 3; (iii) 0.1-0.7 wt % glucose linked at positions 1 and 4; (iv) 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; and (v) about 0.4-1.7 wt % glucose linked at (a) positions 1, 2 and 6, or (b) positions 1, 4 and 6. Aqueous forms of this composition have enhanced viscosity profiles. Further disclosed are methods of using compositions comprising dextran, such as increasing the viscosity of an aqueous composition. Enzymatic reactions for producing dextran are also disclosed.
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公开(公告)号：US11098334B2
公开(公告)日：2021-08-24
申请号：US16218518
申请日：2018-12-13
发明人： Rong Guan , James Joshua Ohane , Nikita Iltchenko , Yefim Brun , Brian McCauley , Laurie A. Howe , Yougen Li
摘要： Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.
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公开(公告)号：US10995435B2
公开(公告)日：2021-05-04
申请号：US15763965
申请日：2016-11-08
发明人： Natnael Behabtu , Joseph F. Roeske , Yefim Brun
IPC分类号： C08B37/00 , D01F9/00 , D01D5/14 , C08L5/00 , D04H1/724 , D04H3/08 , D04H1/4326 , D04H3/009 , C12P19/18 , D04H1/4258 , D04H3/013
摘要： Nonwoven webs comprising a water insoluble α-(1,3→glucan) polymer and methods of forming the nonwoven webs are disclosed. The water insoluble α-(1,3→glucan) polymer comprises 90% or greater α-1,3-glycosidic linkages, less than 1% by weight of α-1,3,6-glycosidic branch points, a number average degree of polymerization in the range of from 55 to 10,000, and a ratio of apparent DPw to true DPw in the range of from 2 to 10. The nonwoven webs can be used for personal hygiene wipes, filtration media, apparel, or other uses.
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公开(公告)号：US11932890B2
公开(公告)日：2024-03-19
申请号：US17406386
申请日：2021-08-19
发明人： Rong Guan , James Joshua Ohane , Nikita Iltchenko , Yefim Brun , Brian McCauley , Laurie A. Howe , Yougen Li
CPC分类号： C12P19/08 , C08B37/0009 , C08B37/0021 , C08J5/18 , C08L5/02 , C11D3/3707 , C12P19/18 , C08J2305/00 , C08J2305/02
摘要： Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.
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公开(公告)号：US11685907B2
公开(公告)日：2023-06-27
申请号：US17015426
申请日：2020-09-09
CPC分类号： C12N9/1048 , C12P19/04 , C12P19/18 , C08B37/0009 , C08B37/0021 , C08L5/00 , C12N15/102 , C12Q1/48 , C12Y204/01027
摘要： A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.
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公开(公告)号：US11608388B2
公开(公告)日：2023-03-21
申请号：US17089817
申请日：2020-11-05
发明人： Kyle Hyun Chang Kim , Yefim Brun , Lucia Daniela Ionescu , Juan David Londono , Jorge Mok , James Joshua Ohane , Lemuel Tong
IPC分类号： C08B37/00 , A61K8/73 , A61K47/36 , A61Q17/04 , C09D7/65 , D21H19/12 , C08L7/00 , C09D175/04 , C08L75/04 , D21H17/24 , A23B7/154 , A23B7/16 , A23L3/349
摘要： Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.
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公开(公告)号：US20210130504A1
公开(公告)日：2021-05-06
申请号：US17089817
申请日：2020-11-05
发明人： Kyle Hyun Chang Kim , Yefim Brun , Lucia Daniela Ionescu , Juan David Londono , Jorge Mok , James Joshua Ohane , Lemuel Tong
IPC分类号： C08B37/00 , A61K8/73 , A61K47/36 , A61Q17/04 , C09D7/65 , D21H19/12 , C08L7/00 , C09D175/04 , C08L75/04 , D21H17/24 , A23B7/154 , A23B7/16 , A23L3/349
摘要： Disclosed herein are compositions comprising insoluble alpha-glucan particles having a high degree of crystallinity and small particle size. For example, the alpha-glucan particles can have a degree of crystallinity of at least about 0.65, and/or an average size of less than a micron. At least 50% of the glycosidic linkages of the insoluble alpha-glucan in the disclosed particles are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing insoluble alpha-glucan particles, as well as their use in various applications and products.
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公开(公告)号：US10988789B2
公开(公告)日：2021-04-27
申请号：US16791030
申请日：2020-02-14
发明人： Mark S. Payne , Yefim Brun , Hongxian He , Thomas Scholz
摘要： Reaction solutions are disclosed herein comprising water, sucrose and a glucosyltransferase enzyme that synthesizes poly alpha-1,3-glucan. The glucosyltransferase enzyme can synthesize insoluble glucan polymer having at least 50% alpha-1,3 glycosidic linkages and a number average degree of polymerization of at least 100. Further disclosed are methods of using such glucosyltransferase enzymes to produce insoluble poly alpha-1,3-glucan.
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公开(公告)号：US20210108240A1
公开(公告)日：2021-04-15
申请号：US17015426
申请日：2020-09-09
摘要： A method for producing insoluble alpha-1,3-glucan is disclosed. Embodiments of the method comprise providing (i) oligosaccharides that comprise alpha-1,3 and alpha-1,6 glycosidic linkages, or (ii) oligosaccharides derived from a glucosyltransferase reaction; and contacting at least water, sucrose, a glucosyltransferase enzyme, and the oligosaccharides provided in the first step. Glucosyltransferase reaction compositions embodying such a method, and insoluble products thereof, are also disclosed. Yield and other product benefits can be realized when practicing the disclosed subject matter.
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