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    DRIED POWDER OF MICROORGANISMS AND METHOD FOR PRODUCING SAME
    1.
    发明申请
    DRIED POWDER OF MICROORGANISMS AND METHOD FOR PRODUCING SAME 有权

    公开(公告)号：US20210040439A1

    公开(公告)日：2021-02-11

    申请号：US16966188

    申请日：2019-01-31

    申请人： Nippon Suisan Kaisha, Ltd.

    发明人： Seizo SATO ,  Takayoshi SEKIGUCHI ,  Yuko ISHIWATA

    IPC分类号： C12N1/12 ,  A61K8/99 ,  A23L5/46 ,  A23L33/115

    摘要： Provided is a dried powder of microorganisms, which is highly suitable for processing and has excellent usefulness as one component of various products. The present invention provides: a dried powder of microorganisms, the dried powder exhibiting a brightness of 55 or more and a chromaticness of 18 or less; and a method for producing a dried powder of microorganisms, the method comprising: washing microorganisms at least once with a liquid having an osmotic pressure lower than that of a liquid culture medium for culturing the microorganisms; and drying and heating the microorganisms after the washing to thereby obtain the dried powder of the microorganisms, which exhibits a brightness of 55 or more and a chromaticness of 18 or less.

    MICROBIAL OIL, PRODUCTION METHOD FOR MICROBIAL OIL, CONCENTRATED MICROBIAL OIL, AND PRODUCTION METHOD FOR CONCENTRATED MICROBIAL OIL
    6.
    发明申请
    MICROBIAL OIL, PRODUCTION METHOD FOR MICROBIAL OIL, CONCENTRATED MICROBIAL OIL, AND PRODUCTION METHOD FOR CONCENTRATED MICROBIAL OIL 审中-公开
    微生物油，微生物油的生产方法，浓缩微生物油和浓缩微生物油的生产方法

    公开(公告)号：US20160317592A1

    公开(公告)日：2016-11-03

    申请号：US15101436

    申请日：2014-12-04

    申请人： NIPPON SUISAN KAISHA, LTD.

    发明人： Hideaki YAMAGUCHI ,  Yuhei KOSUGE ,  Rie IKEDA ,  Nobushige DOISAKI ,  Seizo SATO

    IPC分类号： A61K36/06 ,  A61K31/202 ,  A23K20/158 ,  A23D9/013 ,  A23D9/02

    CPC分类号： A01N37/06 ,  A23D9/013 ,  A23D9/02 ,  A23K20/158 ,  A23L33/115 ,  A61K8/361 ,  A61K8/99 ,  A61K31/202 ,  A61K36/06 ,  A61Q19/00 ,  C11B1/025 ,  C11B3/10 ,  C11B3/12 ,  C11C1/005 ,  C11C3/10 ,  C12N1/28 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463

    摘要： A microbial oil comprising: a specific amount of at least one polyunsaturated fatty acid having at least 20 carbon atoms in fatty acid alkyl ester form and/or in free fatty acid form; and specific amount of thermally-produced fatty acid having from 16 to 22 carbon atoms in a fatty acid alkyl ester form and/or a free fatty acid form. A production method thereof comprising: providing a starting oil containing at least one polyunsaturated fatty acid having at least 20 carbon atoms in an alkyl ester form and/or a free fatty acid form obtained from microbial biomass; performing a rectification of the starting oil under specific conditions; and obtaining the aforementioned microbial oil. A concentrated microbial oil obtained using the production method described above, and a production method thereof. An agent for treating or preventing an inflammatory disease comprising the microbial oil or the concentrated microbial oil.

    摘要翻译： 一种微生物油，其包含：特定量的至少一种在脂肪酸烷基酯形式和/或游离脂肪酸形式中具有至少20个碳原子的多不饱和脂肪酸; 特定量的脂肪酸烷基酯形式的碳原子数为16〜22的热产生脂肪酸和/或游离脂肪酸形式。 一种制备方法，其包括：提供含有至少一种具有至少20个碳原子的多不饱和脂肪酸的起始油，其为烷基酯形式和/或由微生物生物质获得的游离脂肪酸形式; 在特定条件下对原油进行整改; 得到上述微生物油。 使用上述制造方法得到的浓缩微生物油及其制造方法。 用于治疗或预防包含微生物油或浓缩微生物油的炎性疾病的药剂。

    MICROBIAL OIL/LIPID AND METHOD FOR PRODUCING MICROBIAL OIL/LIPID
    7.
    发明申请
    MICROBIAL OIL/LIPID AND METHOD FOR PRODUCING MICROBIAL OIL/LIPID 有权

    公开(公告)号：US20210047663A1

    公开(公告)日：2021-02-18

    申请号：US17050133

    申请日：2019-04-26

    申请人： Nippon Suisan Kaisha, Ltd.

    发明人： Takayoshi SEKIGUCHI ,  Seizo SATO ,  Yuko ISHIWATA

    IPC分类号： C12P7/64 ,  C12N1/12

    摘要： To provide a microbial oil that contains eicosapentaenoic acid (EPA) at a high concentration and can effectively exert the function of EPA. A microbial oil containing EPA and docosahexaenoic acid (DHA), in which the content of EPA is 38% by area or greater relative to the total fatty acids and which has at least one fatty acid ratio selected from the group consisting of (a) to (c): (a) a ratio of the content of EPA to the content of DHA of 1.7 or more; (b) a ratio of the content of fatty acid(s) having 18 carbon atoms to the content of fatty acid(s) having 20 carbon atoms of 0.3 or less; and (c) a ratio of the content of fatty acid(s) having 18 carbon atoms to the content of fatty acid(s) having 22 carbon atoms of 1.5 or less.

    FREE-POLYUNSATURATED-FATTY-ACID-CONTAINING COMPOSITION AND METHOD FOR MANUFACTURING SAME
    8.
    发明申请
    FREE-POLYUNSATURATED-FATTY-ACID-CONTAINING COMPOSITION AND METHOD FOR MANUFACTURING SAME 审中-公开

    公开(公告)号：US20180187126A1

    公开(公告)日：2018-07-05

    申请号：US15906645

    申请日：2018-02-27

    申请人： NIPPON SUISAN KAISHA, LTD.

    发明人： Hideaki YAMAGUCHI ,  Nobushige DOISAKI ,  Seizo SATO ,  Yuhei KOSUGE

    IPC分类号： C11C3/00

    CPC分类号： C11C3/00 ,  A23D9/007 ,  A23L33/12 ,  A23V2002/00 ,  A61K31/201 ,  A61K31/202 ,  C07C57/12 ,  C07C69/58

    摘要： Provided is a free-polyunsaturated-fatty-acid-containing composition that has a total metal content of 0.1 ppm or less and that comprises at least one free polyunsaturated fatty acid having 20 or more carbon atoms, in an amount that is at least 80.0% of the amount of fatty acids in the composition; and a method for manufacturing a free-polyunsaturated-fatty-acid-containing composition, comprising: providing a raw material composition containing at least one polyunsaturated fatty acid having 20 or more carbon atoms; performing a hydrolysis treatment on a reaction solution prepared by combining the provided raw material composition, a lower alcohol, water having a total metal content of 0.01 ppm or less, and an alkali catalyst; and limiting the contact between the reaction composition and the metal after the hydrolysis treatment so that the product T [cm2×days] of the contact surface area [cm2] per 1 g and the contact time [days] between the composition and the metal is 100 or less.

    TRICYCLIC CONDENSED HETEROCYCLIC COMPOUND, METHOD FOR PRODUCING SAME, AND USE THEREOF
    10.
    发明申请
    TRICYCLIC CONDENSED HETEROCYCLIC COMPOUND, METHOD FOR PRODUCING SAME, AND USE THEREOF 审中-公开
    三聚稠合杂环化合物，其生产方法及其用途

    公开(公告)号：US20160237053A1

    公开(公告)日：2016-08-18

    申请号：US15066603

    申请日：2016-03-10

    申请人： NIPPON SUISAN KAISHA, LTD.

    发明人： Seizo SATO ,  Fumie IWATA ,  Shoichi YAMADA ,  Jiro TAKEO ,  Akihisa ABE ,  Hiroyuki KAWAHARA

    IPC分类号： C07D307/93 ,  C12P17/04

    CPC分类号： C07D307/93 ,  C07D307/77 ,  C12P17/04 ,  C12R1/465

    摘要： A compound derived from the culture product of an actinomycete and having an antitumor activity is provided. Provided is a compound represented by any one of formulas (I), (II) and (III) or an optical isomer thereof or a pharmaceutically acceptable salt thereof which can be isolated from the culture fluid of an actinomycete which belongs to the genus Streptomyces, wherein R1, R2, R5 and R6 each independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or a double bond by which R1 and R2 or R5 and R6 are bonded; R3, R4, R7 and R8 each independently represent a methyl group or a hydroxymethyl group; and R9 represents a hydrogen atom or a hydroxyl group.

    摘要翻译： 提供了源自放线菌培养物并具有抗肿瘤活性的化合物。 提供可以从属于链霉菌属的放线菌的培养液中分离出的由式（I），（II）和（III）中任一项所示的化合物或其旋光异构体或其药学上可接受的盐， 其中R1，R2，R5和R6各自独立地表示氢原子，甲基，羟甲基，羟基或R1和R2或R5和R6键合的双键; R 3，R 4，R 7和R 8各自独立地表示甲基或羟甲基; 并且R 9表示氢原子或羟基。