公开(公告)号：US20160237053A1

公开(公告)日：2016-08-18

申请号：US15066603

申请日：2016-03-10

申请人： NIPPON SUISAN KAISHA, LTD.

发明人： Seizo SATO ,  Fumie IWATA ,  Shoichi YAMADA ,  Jiro TAKEO ,  Akihisa ABE ,  Hiroyuki KAWAHARA

IPC分类号： C07D307/93 ,  C12P17/04

CPC分类号： C07D307/93 ,  C07D307/77 ,  C12P17/04 ,  C12R1/465

摘要： A compound derived from the culture product of an actinomycete and having an antitumor activity is provided. Provided is a compound represented by any one of formulas (I), (II) and (III) or an optical isomer thereof or a pharmaceutically acceptable salt thereof which can be isolated from the culture fluid of an actinomycete which belongs to the genus Streptomyces, wherein R1, R2, R5 and R6 each independently represent a hydrogen atom, a methyl group, a hydroxymethyl group, a hydroxyl group, or a double bond by which R1 and R2 or R5 and R6 are bonded; R3, R4, R7 and R8 each independently represent a methyl group or a hydroxymethyl group; and R9 represents a hydrogen atom or a hydroxyl group.

摘要翻译： 提供了源自放线菌培养物并具有抗肿瘤活性的化合物。 提供可以从属于链霉菌属的放线菌的培养液中分离出的由式（I），（II）和（III）中任一项所示的化合物或其旋光异构体或其药学上可接受的盐， 其中R1，R2，R5和R6各自独立地表示氢原子，甲基，羟甲基，羟基或R1和R2或R5和R6键合的双键; R 3，R 4，R 7和R 8各自独立地表示甲基或羟甲基; 并且R 9表示氢原子或羟基。