公开(公告)号：US11786168B2

公开(公告)日：2023-10-17

申请号：US16616898

申请日：2018-06-01

申请人： NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： John A. Rogers ,  Johnathan T. Reeder ,  Amay J. Bandodkar ,  Sungbong Kim ,  Yurina Sekine ,  Jungil Choi ,  Tyler R. Ray ,  Aurelie Hourlier-Fargette ,  Philipp Gutruf ,  Kun Hyuck Lee ,  Milan Raj

IPC分类号： A61B5/00 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/145 ,  A61B5/1477 ,  A61B5/01 ,  A61B5/103

CPC分类号： A61B5/4266 ,  A61B5/0022 ,  A61B5/01 ,  A61B5/1032 ,  A61B5/1455 ,  A61B5/1477 ,  A61B5/1486 ,  A61B5/14517 ,  A61B5/14532 ,  A61B5/14539 ,  A61B5/14546 ,  A61B2562/0242 ,  A61B2562/0276 ,  A61B2562/164

摘要： The invention provides a versatile sensing platform for sensing and analysis of biofluids, particularly well-suited for sensing and analysis of sweat. Systems of the invention allows for sensitive and selective detection of a range of analytes in sweat including metabolites, electrolytes and biomarkers. Systems of the invention provide a noninvasive and accurate means for quantitative characterization of important sweat characteristics including sweat volume, sweat loss and sweat rate. Systems of the invention are compatible with materials and device geometries for important class of conformal tissue mounted electronic devices, including epidermal electronic devices.

公开(公告)号：US10925523B2

公开(公告)日：2021-02-23

申请号：US16616770

申请日：2018-06-01

申请人： NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： John A. Rogers ,  Jungil Choi ,  Tyler R. Ray ,  Johnathan T. Reeder ,  Yurina Sekine ,  Amay J. Bandodkar ,  Yi Zhang ,  Hexia Guo ,  Sungbong Kim ,  Diana Ostojich

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/053 ,  A61B5/103 ,  A61B5/1455 ,  B01L3/00

摘要： Provided are microfluidic systems for monitoring a biofluid property and related methods. Specially configured microfluidic networks and associated structural support and functional elements, including flexible substrates, capping layers, and fluidic conduits and controllers, provide reliable biofluid collection. Optical components and indicators provide a reliable and readily observable readout, including of any of a number of biofluid properties, including directly from biofluid collected in the microfluidic network.

公开(公告)号：US11977082B2

公开(公告)日：2024-05-07

申请号：US17183638

申请日：2021-02-24

申请人： NORTHWESTERN UNIVERSITY

发明人： John A. Rogers ,  Jungil Choi ,  Johnathan T. Reeder

IPC分类号： G01N33/68 ,  A61B5/00 ,  A61B5/145 ,  C12M3/06 ,  G01N33/543

CPC分类号： G01N33/6881 ,  A61B5/0002 ,  A61B5/14517 ,  A61B5/6833 ,  C12M23/16 ,  G01N33/54366 ,  A61B2503/10 ,  A61B2562/164

摘要： Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.

公开(公告)号：US11883165B2

公开(公告)日：2024-01-30

申请号：US17027887

申请日：2020-09-22

申请人： NORTHWESTERN UNIVERSITY ,  THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： John A. Rogers ,  Jungil Choi ,  Tyler R. Ray ,  Johnathan T. Reeder ,  Yurina Sekine ,  Amay J. Bandodkar ,  Yi Zhang ,  Hexia Guo ,  Sungbong Kim ,  Diana Ostojich

IPC分类号： A61B5/145 ,  A61B5/00 ,  A61B5/053 ,  A61B5/103 ,  A61B5/1455 ,  B01L3/00

CPC分类号： A61B5/14539 ,  A61B5/0002 ,  A61B5/053 ,  A61B5/1032 ,  A61B5/1455 ,  A61B5/14517 ,  A61B5/14546 ,  A61B5/4842 ,  A61B5/6806 ,  B01L3/502715 ,  A61B5/6833 ,  A61B2562/028 ,  A61B2562/164 ,  B01L2300/025 ,  B01L2300/0663 ,  B01L2300/0803 ,  B01L2300/0864 ,  B01L2300/123 ,  B01L2400/0406 ,  B01L2400/0688

摘要： A microfluidic system includes a flexible substrate having a skin-facing surface and a back-facing surface; a microfluidic network at least partially embedded in or supported by the flexible substrate; a sensor fluidically connected to the microfluidic network, wherein the microfluidic network is configured to transport a biofluid from a skin surface to the sensor; and a capping layer, having a capping layer skin-facing surface and a back-facing surface, wherein the back-facing surface of the capping layer is attached to the skin-facing surface of the substrate. The flexible substrate is at least partially formed of a thermoplastic elastomer or a polymer configured to provide a high barrier to vapor or liquid water transmission.

公开(公告)号：US10969395B2

公开(公告)日：2021-04-06

申请号：US16616859

申请日：2018-06-01

申请人： NORTHWESTERN UNIVERSITY

发明人： John A. Rogers ,  Jungil Choi ,  Johnathan T. Reeder

IPC分类号： G01N33/68 ,  A61B5/145 ,  A61B5/00 ,  C12M3/06 ,  G01N33/543

摘要： Provided herein are epidermal microfluidic systems and methods that allow for the collection of biofluids in a wet or aquatic environment, for example, from the surface of the skin. The described systems allow for the efficient collection of biofluids, without loss of the biofluid to the surrounding environment or introduction of extraneous liquids from the environment. The described microfluidic systems are versatile and can provide information regarding a number of biofluid properties both electronically and colorimetrically/visually.