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公开(公告)号：US07611781B1
公开(公告)日：2009-11-03
申请号：US10111388
申请日：2000-10-31
申请人： Tadashi Kokubo , Masahiro Nawa , Masaki Uchida
发明人： Tadashi Kokubo , Masahiro Nawa , Masaki Uchida
CPC分类号： A61L27/10 , A61K6/0008 , A61K6/0017 , A61K6/0044 , A61K6/024 , A61K6/025 , A61K6/033 , A61L27/025 , A61L27/32 , A61L27/425
摘要： A hard tissue repairing material includes zirconia as a base material. A surface of the base material has a hydrophilic group. The hydrophilic group is bonded to zirconium atom in the base material. The base material may contain at least an ionic component that is selected from a group consisting of calcium ion, sodium ion, potassium ion, and phosphate ions within the surface. A hard tissue repairing material may include zirconia as a base material and a layer of a main component of an apatite. The layer of the apatite may be formed on a hydrophilic group bonded to zirconium atom in the base material.
摘要翻译： 硬组织修复材料包括氧化锆作为基材。 基材的表面具有亲水性基团。 亲水基团与基材中的锆原子结合。 基材可以含有至少一种选自表面内的钙离子，钠离子，钾离子和磷酸根离子的离子成分。 硬组织修复材料可以包括作为基础材料的氧化锆和磷灰石的主要成分的层。 磷灰石层可以在基材中与锆原子结合的亲水基上形成。
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公开(公告)号：US06569547B2
公开(公告)日：2003-05-27
申请号：US09969772
申请日：2001-10-04
申请人： Masahiro Nawa , Tadashi Kokubo , Masaki Uchida
发明人： Masahiro Nawa , Tadashi Kokubo , Masaki Uchida
IPC分类号： B32B900
CPC分类号： A61L27/306
摘要： A hard tissue repairing material including a base material and a surface layer having a crystalline zirconia covering the base material, being characterized in that the film includes a Zr—OH group. A middle layer may be formed between the base material and the surface layer and, in such case, includes at least one element of the base material and at least one element of the surface layer having a crystalline zirconia.
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公开(公告)号：US07829196B2
公开(公告)日：2010-11-09
申请号：US12420244
申请日：2009-04-08
申请人： Tadashi Kokubo , Masahiro Nawa , Masaki Uchida
发明人： Tadashi Kokubo , Masahiro Nawa , Masaki Uchida
IPC分类号： B32B9/00
CPC分类号： A61L27/10 , A61K6/0008 , A61K6/0017 , A61K6/0044 , A61K6/024 , A61K6/025 , A61K6/033 , A61L27/025 , A61L27/32 , A61L27/425
摘要： A hard tissue repairing material includes zirconia as a base material. A surface of the base material has a hydrophilic group. The hydrophilic group is bonded to zirconium atom in the base material. The base material may contain at least an ionic component that is selected from a group consisting of calcium ion, sodium ion, potassium ion, and phosphate ions within the surface. A hard tissue repairing material may include zirconia as a base material and a layer of a main component of an apatite. The layer of the apatite may be formed on a hydrophilic group bonded to zirconium atom in the base material.
摘要翻译： 硬组织修复材料包括氧化锆作为基材。 基材的表面具有亲水性基团。 亲水基团与基材中的锆原子结合。 基材可以含有至少一种选自表面内的钙离子，钠离子，钾离子和磷酸根离子的离子成分。 硬组织修复材料可以包括作为基础材料的氧化锆和磷灰石的主要成分的层。 磷灰石层可以在基材中与锆原子结合的亲水基上形成。
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4.发明授权Curable resin composition, curable resin composition tablet, molded body, semiconductor package, semiconductor component and light emitting diode 有权可固化树脂组合物，可固化树脂组合物片，模塑体，半导体封装，半导体组件和发光二极管公开(公告)号：US09178120B2
公开(公告)日：2015-11-03
申请号：US13638992
申请日：2011-03-30
申请人： Tadashi Kokubo , Katsuya Ouchi , Takahisa Iwahara , Kazuhiko Hirabayashi , Hiroshi Okoshi , Tomokazu Tozawa , Shuhei Ozaki
发明人： Tadashi Kokubo , Katsuya Ouchi , Takahisa Iwahara , Kazuhiko Hirabayashi , Hiroshi Okoshi , Tomokazu Tozawa , Shuhei Ozaki
IPC分类号： H01L33/56 , H01L23/29 , H01L33/60 , H01L23/31 , C08K3/22 , C08K3/36 , C08K5/098 , H01L23/495 , H01L33/62
CPC分类号： H01L33/56 , C08K3/22 , C08K3/36 , C08K5/098 , C08K2003/2241 , H01L23/295 , H01L23/296 , H01L23/3171 , H01L23/49586 , H01L33/60 , H01L33/62 , H01L2924/0002 , H01L2924/00
摘要： The present invention aims to provide a curable resin composition which gives a cured product having a low linear expansion coefficient. The curable resin composition of the present invention contains, as essential components, (A) an organic compound having at least two carbon-carbon double bonds reactive with SiH groups per molecule, (B) a compound containing at least two SiH groups per molecule, (C) a hydrosilylation catalyst, (D) a silicone compound having at least one carbon-carbon double bond reactive with a SiH group per molecule, and (E) an inorganic filler.
摘要翻译： 本发明的目的在于提供一种固化性树脂组合物，其具有低的线性膨胀系数的固化物。 本发明的固化性树脂组合物含有作为必要成分的（A）每分子具有至少两个与SiH基反应的碳 - 碳双键的有机化合物，（B）每分子含有至少两个SiH基的化合物， （C）氢化硅烷化催化剂，（D）每分子具有至少一个与SiH基反应的碳 - 碳双键的硅氧烷化合物和（E）无机填料。
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公开(公告)号：US08784864B2
公开(公告)日：2014-07-22
申请号：US13147082
申请日：2010-01-29
CPC分类号： A61F2/30767 , A61F2002/30838 , A61F2002/3084 , A61F2310/00023 , A61F2310/00616 , A61L27/06 , A61L2400/18 , A61L2430/02
摘要： Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 μm in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 μm in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.
摘要翻译： 公开了骨修复材料，其中离子几乎不在生物体中洗脱，并且磷灰石形成能力和磷灰石剥离性都优异，并且具有足够高的实用用途的耐擦伤性。 该材料包括由钛或钛合金制成的基材，以及基本上由氧化钛制成的表面层。 基板在表面上的宽度和深度均匀地具有1nm至10μm的不规则性。 在pH6〜8的水溶液环境下，该层的ζ电位为+4.5mV以上，当振幅为100μm的振幅加入弹簧常数为200的触针时，临界耐擦伤性为35mN以上 表面层上的g / mm和触针以10毫米/秒的速率移动，负载以100毫微米/分钟的速率增加。
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6.发明申请公开(公告)号：US20060204491A1
公开(公告)日：2006-09-14
申请号：US10560744
申请日：2004-03-29
CPC分类号： A61K33/24 , A61F2/28 , A61F2/3094 , A61F2310/00227 , A61L27/446
摘要： The titanium oxide-organic polymer composite material for artificial bone obtained by forming titania gel on the surface of said base material by titania solution treatment to dip into a solution of 0° C. to 50° C. temperature for from several seconds to 1 week obtained by adding a solution consisting of acidic alcohol and water into alcohol solution of titaniumtetraalcoxide to a base material composed of a polymer compound selected from a group consisting of polyolefin, polyester and nylon, and modifying to a titanium oxide membrane which forms apatite having similar Ca/P atom ratio to an apatite of mammalian's bone in supersaturated aqueous solution to apatite or from a body fluid of mammalian by dipping said base material on the surface of which titania gel is formed into hot water of 50° C. to 95° C. or solution of room temperature to 95° C. to which acid is added.
摘要翻译： 通过二氧化钛溶液处理在所述基材的表面上形成二氧化钛凝胶而获得的用于人造骨的二氧化钛 - 有机聚合物复合材料，以将其浸入0℃至50℃的温度下从数秒到1周 通过将由酸性醇和水组成的溶液加入到由四氯环氧化物的醇溶液中组成的基材上，所述基材由选自聚烯烃，聚酯和尼龙的聚合物化合物组成，并且改性成形成具有类似Ca的磷灰石的氧化钛膜 / P原子与哺乳动物骨骼的磷灰石相对于磷灰石或来自哺乳动物的体液的哺乳动物骨骼的磷酸盐，将其形成的热水中的所述基材浸渍在50℃至95℃的热水中 或室温至95℃的溶液加入酸。
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公开(公告)号：US20060122708A1
公开(公告)日：2006-06-08
申请号：US10541671
申请日：2004-01-07
IPC分类号： A61F2/28
CPC分类号： A61L27/06 , A61L27/306 , A61L27/56 , A61L2430/02
摘要： An artificial bone is disclosed. The artificial bone comprises: a porous body comprising a lump of titanium or titanium alloy and having a porosity of 30 to 80%, the body having a interconnected pore (3) with a diameter of 100 to 3000 μm and a hole (4) with a diameter of 50 μm or less on an inner surface of the pore; and a film formed on at least a part of a surface of the pore and the hole, the film comprising at least one phase selected from an amorphous titanium oxide phase, an amorphous alkali titanate phase, an anatase phase and a rutile phase aligned with (101) plane. The artificial bone has high strength and osteoinductivity.
摘要翻译： 公开了一种人造骨。 人造骨包括：多孔体，其包含钛或钛合金块，孔隙率为30〜80％，主体具有直径为100〜3000μm的互连孔（3），孔（4）具有 在孔的内表面上的直径为50μm或更小; 以及形成在所述孔和孔的表面的至少一部分上的膜，所述膜包含选自非晶态氧化钛相，无定形碱金属钛酸盐相，锐钛矿相和与（ 101）飞机。 人造骨具有高强度和骨诱导性。
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公开(公告)号：US08470387B2
公开(公告)日：2013-06-25
申请号：US12995850
申请日：2009-06-01
CPC分类号： A61L27/06 , A61F2/30767 , A61F2310/00023 , A61L27/30 , A61L2430/02
摘要： A bone repair material being superior in apatite-forming ability and its stability in a storage and high in scratch resistance is disclosed. The material is produced by a method comprising the steps of: immersing a substrate made of titanium or a titanium alloy in a first aqueous solution that does not contain calcium ions but contains at least one cation selected from the group consisting of sodium ions and potassium ions and is alkaline; immersing the substrate in a second aqueous solution that does not contain phosphate ions but contains calcium ions; heating the substrate in a dry atmosphere; and treating the substrate with hot water of 60° C. or higher or with steam.
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公开(公告)号：US20110287070A1
公开(公告)日：2011-11-24
申请号：US13147082
申请日：2010-01-29
CPC分类号： A61F2/30767 , A61F2002/30838 , A61F2002/3084 , A61F2310/00023 , A61F2310/00616 , A61L27/06 , A61L2400/18 , A61L2430/02
摘要： Bone repair materials are disclosed, from which ions are hardly eluted in living body and which are superior in apatite-forming ability and resistance to apatite peeling and have a scratch resistance high enough for practical use. The material comprises a substrate made of titanium or titanium alloys, and a surface layer, made substantially of titanium oxide, along the surface of the substrate. The substrate has on the surface thereof irregularities of from 1 nm to 10 μm in average in both width and depth. The layer has a zeta potential of +4.5 mV or more under an aqueous solution environment of pH 6 to 8, and a critical scratch resistance of 35 mN or more when vibration 100 μm in amplitude is added to a stylus with a spring constant of 200 g/mm on the surface layer and the stylus is moved at a rate of 10 mm/sec under a load increasing at a rate of 100 mN/min.
摘要翻译： 公开了骨修复材料，其中离子几乎不在生物体中洗脱，并且磷灰石形成能力和磷灰石剥离性都优异，并且具有足够高的实用用途的耐擦伤性。 该材料包括由钛或钛合金制成的基材，以及基本上由氧化钛制成的表面层。 基板在表面上的宽度和深度均匀地具有1nm至10μm的不规则性。 在pH6〜8的水溶液环境下，该层的ζ电位为+4.5mV以上，当将振幅为100μm的振幅加到弹簧常数为200的触笔上时，临界耐擦伤性为35mN以上 表面层上的g / mm和触针以10毫米/秒的速率移动，负载以100毫微米/分钟的速率增加。
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公开(公告)号：US20090317278A1
公开(公告)日：2009-12-24
申请号：US12439326
申请日：2007-08-28
申请人： Tadashi Kokubo
发明人： Tadashi Kokubo
CPC分类号： A61L27/06 , A61F2/28 , A61F2/4455 , A61F2/4465 , A61F2/447 , A61F2002/30006 , A61F2002/30011 , A61F2002/30133 , A61F2002/30153 , A61F2002/30156 , A61F2002/30271 , A61F2002/30593 , A61F2002/30787 , A61F2002/30843 , A61F2002/30892 , A61F2002/30957 , A61F2002/30968 , A61F2002/4475 , A61F2230/0015 , A61F2230/0019 , A61F2230/0023 , A61F2230/0082 , A61F2250/0015 , A61F2250/0023 , A61F2310/00023 , A61L27/56 , A61L2430/02
摘要： An artificial bone which is easy to bond to a living bone and has a mechanical property approximate to that of a living bone is disclosed. The artificial bone comprises: a dense part made of titanium or a titanium alloy, in the shape of a frame that is approximate to a part of an outer face of a living bone, having a density of 95% or more; and a porous part made of sintered particles of titanium or a titanium alloy having the same or different composition as the titanium alloy for the dense part, in the shape approximate to the remaining part of the living bone, having a porosity of 40% or more, the dense part and the particles of the porous part being sintered to each other at an interface between the dense part and the porous part.
摘要翻译： 公开了一种人造骨，其容易结合活性骨并具有接近于活骨的机械性能。 人造骨包括：密度为95％以上的由钛或钛合金制成的致密部分，其形状为近似于活骨的外表面的一部分的框架; 以及具有与用于致密部分的钛合金相同或不同的组成的钛或钛合金的烧结颗粒制成的多孔部分，其形状接近活体骨的剩余部分，孔隙率为40％以上 ，多孔部分的致密部分和颗粒在致密部分和多孔部分之间的界面处彼此烧结。
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