公开(公告)号：US20050026829A1

公开(公告)日：2005-02-03

申请号：US10824075

申请日：2004-04-14

申请人： Mary Gerritsen ,  Jo-Anne Hongo ,  Constance Zlot

发明人： Mary Gerritsen ,  Jo-Anne Hongo ,  Constance Zlot

IPC分类号： A61K38/00 ,  A61K38/17 ,  C07K14/575

CPC分类号： C07K14/575 ,  A61K38/00

摘要： The invention provides methods and compositions for modulating vascularization and angiogenesis, including selective modulation of stages of multi-step vascularization and angiogenesis.

摘要翻译： 本发明提供了用于调节血管形成和血管发生的方法和组合物，包括多步血管形成和血管发生的阶段的选择性调节。

公开(公告)号：US20070092513A1

公开(公告)日：2007-04-26

申请号：US11581221

申请日：2006-10-13

申请人： Mary Gerritsen ,  Mark Sliwkowski

发明人： Mary Gerritsen ,  Mark Sliwkowski

IPC分类号： A61K39/395

CPC分类号： C07K14/82 ,  A61K38/00 ,  C07K14/4756 ,  C07K16/32 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  C07K2319/30 ,  G01N33/5061

摘要： The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.

摘要翻译： 本发明涉及通过使用天然ErbB4受体的拮抗剂来控制平滑肌细胞的过度增殖和/或迁移，特别是用于治疗狭窄的方法和手段。 本发明还涉及鉴定能够抑制或增强平滑肌细胞增殖或迁移的ErbB4激动剂和拮抗剂的方法。

公开(公告)号：US20060074221A1

公开(公告)日：2006-04-06

申请号：US10219064

申请日：2002-08-13

申请人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

发明人： Kevin Baker ,  Luc Desnoyers ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Victoria Smith ,  Jean-Philippe Stephan ,  Colin Watanabe ,  William Wood

IPC分类号： C07K14/47 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K16/18

CPC分类号： C07K14/705 ,  C07K14/47 ,  G01N33/574

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20060040351A1

公开(公告)日：2006-02-23

申请号：US10973115

申请日：2004-10-22

申请人： Kevin Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy Stewart ,  Daniel Tumas ,  Colin Watanabe ,  William Wood ,  Zemin Zhang

发明人： Kevin Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy Stewart ,  Daniel Tumas ,  Colin Watanabe ,  William Wood ,  Zemin Zhang

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20050227328A1

公开(公告)日：2005-10-13

申请号：US11129762

申请日：2005-05-13

申请人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

发明人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

IPC分类号： A61K38/00 ,  A61K39/395 ,  C07K14/47 ,  C07K14/705 ,  C07K16/28 ,  C12N5/10 ,  C12N15/12 ,  C12N15/62 ,  C12N15/63 ,  C07H21/04 ,  C07K16/18 ,  C12N9/00 ,  C12N15/09

CPC分类号： C07K14/47 ,  A61K38/00

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20050202008A1

公开(公告)日：2005-09-15

申请号：US11032294

申请日：2005-01-10

申请人： P. Mickey Williams ,  Mary Gerritsen

发明人： P. Mickey Williams ,  Mary Gerritsen

IPC分类号： G01N33/50 ,  A61K38/00 ,  A61K38/17 ,  A61K39/395 ,  A61K45/00 ,  A61P1/04 ,  A61P3/10 ,  A61P7/02 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P15/00 ,  A61P17/02 ,  A61P17/06 ,  A61P19/10 ,  A61P21/00 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P35/00 ,  A61P41/00 ,  A61P43/00 ,  C07K14/47 ,  C12N15/09 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/53 ,  G01N33/566 ,  G01N33/574

CPC分类号： G01N33/566 ,  A61K38/177 ,  C07K14/47 ,  C07K2319/30 ,  C12N2799/026 ,  G01N2333/525 ,  G01N2333/70575 ,  G01N2333/70578

摘要： Compositions and methods are disclosed for stimulating or inhibiting angiogenesis and/or cardiovascularization in mammals, including humans. Pharmaceutical compositions are based on polypeptides or antagonists thereto that have been identified for one or more of these uses. Disorders that can be diagnosed, prevented, or treated by the compositions herein include trauma such as wounds, various cancers, and disorders of the vessels including atherosclerosis and cardiac hypertrophy.

摘要翻译： 公开了用于刺激或抑制哺乳动物，包括人类的血管发生和/或心血管化的组合物和方法。 药物组合物基于已被鉴定为一种或多种这些用途的多肽或其拮抗剂。 可以通过本文组合物诊断，预防或治疗的疾病包括创伤，例如创伤，各种癌症和血管障碍，包括动脉粥样硬化和心脏肥大。

公开(公告)号：US20050124789A9

公开(公告)日：2005-06-09

申请号：US09978824

申请日：2001-10-16

申请人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William Wood

发明人： Avi Ashkenazi ,  Kevin Baker ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  J. Christopher Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Sophia Kuo ,  Mary Napier ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  David Shelton ,  Timothy Stewart ,  Daniel Tumas ,  P. Mickey Williams ,  William Wood

IPC分类号： A61K31/17 ,  A61K38/00 ,  A61K38/17 ,  A61K38/43 ,  A61K39/395 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/435 ,  C07K14/47 ,  C07K14/52 ,  C07K14/54 ,  C07K14/705 ,  C07K16/18 ,  C07K16/28 ,  C07K16/40 ,  C12N5/06 ,  C12N9/00 ,  C12P21/02 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/574 ,  G01N33/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00 ,  C07K14/4702 ,  C07K14/4703 ,  C07K14/475 ,  C07K14/52 ,  C07K14/521 ,  C07K14/54 ,  C07K14/705 ,  C07K14/70503 ,  C07K14/70578 ,  C07K16/18 ,  C07K16/28 ,  C07K2317/24 ,  C07K2319/00 ,  C07K2319/30 ,  C12N9/00 ,  C12N2799/026 ,  C12N2799/027 ,  G01N33/573 ,  G01N33/57484 ,  G01N33/68 ,  G01N2333/99 ,  G01N2800/042

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20050079582A1

公开(公告)日：2005-04-14

申请号：US10963467

申请日：2004-10-11

申请人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Jennie Mather ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

发明人： Avi Ashkenazi ,  David Botstein ,  Luc Desnoyers ,  Dan Eaton ,  Napoleone Ferrara ,  Ellen Filvaroff ,  Sherman Fong ,  Wei-Qiang Gao ,  Hanspeter Gerber ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Christopher Grimaldi ,  Austin Gurney ,  Kenneth Hillan ,  Ivar Kljavin ,  Jennie Mather ,  James Pan ,  Nicholas Paoni ,  Margaret Roy ,  Timothy Stewart ,  Daniel Tumas ,  P. Williams ,  William Wood

IPC分类号： C07H21/04 ,  C07K14/47 ,  C07K16/18 ,  C12N1/21 ,  C12N5/10 ,  C12N9/00 ,  C12N15/12 ,  C12N15/63

CPC分类号： C07K14/47 ,  C07K16/18 ,  C07K16/28

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

公开(公告)号：US20070264686A1

公开(公告)日：2007-11-15

申请号：US11553810

申请日：2006-10-27

申请人： Kevin Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy Stewart ,  Daniel Tumas ,  Colin Watanabe ,  William Wood ,  Zemin Zhang

发明人： Kevin Baker ,  Maureen Beresini ,  Laura DeForge ,  Luc Desnoyers ,  Ellen Filvaroff ,  Wei-Qiang Gao ,  Mary Gerritsen ,  Audrey Goddard ,  Paul Godowski ,  Austin Gurney ,  Steven Sherwood ,  Victoria Smith ,  Timothy Stewart ,  Daniel Tumas ,  Colin Watanabe ,  William Wood ,  Zemin Zhang

IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C07K14/47 ,  C07K16/18

摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。

公开(公告)号：US20070141068A1

公开(公告)日：2007-06-21

申请号：US11671987

申请日：2007-02-06

申请人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

发明人： Mary Gerritsen ,  Franklin Peale ,  Thomas Wu

IPC分类号： A61K39/395 ,  C07K16/30

CPC分类号： G01N33/57438 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/82 ,  C07K16/30 ,  C07K16/3076 ,  G01N33/57484 ,  G01N2333/726 ,  G01N2500/00

摘要： The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based upon the identification of genes that are amplified in the genome of tumor cells, such as renal cell carcinoma. Such gene amplification is expected to be associated with the overexpression of the gene product as compared to normal cells of the same tissue type and contribute to tumorigenesis. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, such as renal cell carcinoma, and may act as predictors of the prognosis of tumor treatment. The present invention is directed to novel methods of diagnosing and treating tumor, such as renal cell carcinoma or Wilms tumor.