公开(公告)号：US20220235028A1

公开(公告)日：2022-07-28

申请号：US17615718

申请日：2020-06-08

Applicant: Yongxin HAN ,  Yongqi DENG ,  Hua ZHOU ,  Meredeth A. MCGOWAN ,  Hongjun ZHANG ,  Wensheng YU ,  Brett A. HOPKINS ,  Xavier FRADERA ,  Nunzio SCIAMMETTA ,  Merck Sharp & Dohme Corp.

Inventor： Yongxin Han ,  Yongqi Deng ,  Hua Zhou ,  Meredeth A. McGowan ,  Hongjun Zhang ,  Wensheng Yu ,  Brett A. Hopkins ,  Xavier Fradera ,  Nunzio Sciammetta

IPC: C07D401/06 ,  C07D401/08 ,  C07D471/04 ,  C07D519/00

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11319283B2

公开(公告)日：2022-05-03

申请号：US16753035

申请日：2018-10-04

Applicant: MERCK SHARP & DOHME CORP. ,  Meredeth Ann McGowan ,  Abdelghani Achab ,  Xavier Fradera ,  Yongxin Han ,  Derun Li ,  Jongwon Lim ,  Kun Liu ,  Nunzio Sciammetta ,  Catherine M. White ,  Wensheng Yu ,  Hongjun Zhang ,  Hua Zhou

Inventor： Meredeth Ann McGowan ,  Abdelghani Achab ,  Xavier Fradera ,  Yongxin Han ,  Derun Li ,  Jongwon Lim ,  Kun Liu ,  Nunzio Sciammetta ,  Catherine M. White ,  Wensheng Yu ,  Hongjun Zhang ,  Hua Zhou

IPC: C07D205/04 ,  C07C237/42 ,  C07D213/75 ,  C07D213/82 ,  C07D231/14 ,  C07D233/90 ,  C07D237/20 ,  C07D239/28 ,  C07D241/24 ,  C07D263/34 ,  C07D277/56 ,  C07D285/06 ,  C07D307/14 ,  C07D309/14 ,  C07D487/04

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: (Formula (I)). Also disclosed herein are uses of a compound disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of a composition in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11034661B2

公开(公告)日：2021-06-15

申请号：US16495883

申请日：2018-03-23

Applicant: Merck Sharp & Dohme Corp. ,  Liangqin Guo ,  Yongxin Han ,  Kun Liu ,  Shuwen He ,  Joseph Kozlowski ,  Ravi Nargund ,  Wensheng Yu ,  Hongjun Zhang ,  Qinglin Pu ,  Derun Li ,  Abdelghani Achab ,  Guoqing Li

Inventor： Liangqin Guo ,  Yongxin Han ,  Kun Liu ,  Shuwen He ,  Joseph Kozlowski ,  Ravi Nargund ,  Wensheng Yu ,  Hongjun Zhang ,  Qinglin Pu ,  Derun Li ,  Abdelghani Achab ,  Guoqing Li

IPC: C07D271/08 ,  C07D413/12

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof. Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10988487B2

公开(公告)日：2021-04-27

申请号：US16326408

申请日：2017-08-24

Applicant: Merck Sharp & Dohme Corp.

Inventor： Kun Liu ,  Abdelghani Achab ,  Purakkattle Biju ,  Timothy A. Cernak ,  Yongqi Deng ,  Xavier Fradera ,  Liangqin Guo ,  Yongxin Han ,  Shuwen He ,  Joseph Kozlowski ,  Derun Li ,  Guoqing Li ,  Qinglin Pu ,  Zhi-Cai Shi ,  Wensheng Yu ,  Hongjun Zhang

IPC: C07F5/02 ,  C07D271/08 ,  C07D413/12

Abstract: Disclosed herein is a compound of formula (I), or a pharmaceutically acceptable salt thereof: Formula (I). Also disclosed herein are uses of the compounds disclosed herein in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising a compound disclosed herein. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10538497B2

公开(公告)日：2020-01-21

申请号：US16061597

申请日：2016-12-12

Applicant: Merck Sharp & Dohme Corp.

Inventor： Yongxin Han ,  Abdelghani Achab ,  Purakkattle Biju ,  Yongqi Deng ,  Xavier Fradera ,  Liangqin Guo ,  Shuwen He ,  Joseph Kozlowski ,  Ravi Kurukulasuriya ,  Kun Liu ,  Meredeth Ann McGowan ,  Qinglin Pu ,  Nunzio Sciammetta ,  Hongjun Zhang ,  Hua Zhou

IPC: A61K31/4245 ,  A61K31/433 ,  C07D271/08 ,  C07D285/10 ,  C07D413/12 ,  C07D417/12 ,  A61P35/00 ,  A61P31/12 ,  A61P25/24 ,  A61P25/28 ,  A61P37/06 ,  A61P27/12 ,  A61P31/14 ,  A61P35/02

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US10221142B2

公开(公告)日：2019-03-05

申请号：US15549465

申请日：2016-02-11

Applicant: Merck Sharp & Dohme Corp.

Inventor： Blair T. Lapointe ,  Peter H. Fuller ,  Hakan Gunaydin ,  Kun Liu ,  Nunzio Sciammetta ,  Benjamin Wesley Trotter ,  Hongjun Zhang ,  Kenneth J. Barr ,  John K. F. Maclean ,  Danielle F. Molinari ,  Vladimir Simov

IPC: C07D231/56 ,  C07D487/04 ,  A61K45/06 ,  A61K31/416 ,  C07D471/04 ,  C07D491/052 ,  C07D491/107 ,  C07D495/04 ,  C07D403/12 ,  C07D487/14 ,  C07D405/12 ,  C07D413/06 ,  C07D487/06 ,  C07D513/04

Abstract: The present invention relates to compounds according to Formula (I-1) and pharmaceutically acceptable salts thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.

公开(公告)号：US20180305320A1

公开(公告)日：2018-10-25

申请号：US15770255

申请日：2016-10-27

Applicant: Merck Sharp & Dohme Corp.

Inventor： Blair T. Lapointe ,  Peter H. Fuller ,  Hakan Gunaydin ,  Kun Liu ,  Danielle F. Molinari ,  Qinglin Pu ,  Mark E. Scott ,  B. Wesley Trotter ,  Hongjun Zhang

IPC: C07D231/56 ,  C07D401/04 ,  C07D491/052 ,  C07D471/04 ,  C07D491/107 ,  A61P19/02 ,  A61P17/06 ,  A61P29/00 ,  A61P37/02 ,  A61P11/06

CPC classification number: C07D231/56 ,  A61K2121/00 ,  A61P11/06 ,  A61P17/06 ,  A61P19/02 ,  A61P29/00 ,  A61P37/02 ,  C07D401/04 ,  C07D471/04 ,  C07D491/052 ,  C07D491/107

Abstract: The present invention relates to compounds according to Formula I: and pharmaceutically acceptable salts thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.

公开(公告)号：US09487490B2

公开(公告)日：2016-11-08

申请号：US14421057

申请日：2013-08-14

Applicant: Merck Sharp & Dohme Corp.

Inventor： Kenneth J. Barr ,  John K. Maclean ,  Hongjun Zhang ,  Richard T. Beresis ,  Dongshan Zhang ,  Brian M. Andresen ,  Neville J. Anthony ,  Blair T. Lapointe ,  Nunzio Sciammetta

IPC: C07D471/04 ,  A61K31/4745 ,  C07D231/56 ,  A61K31/404 ,  A61K31/416 ,  A61K31/437 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  C07D209/26 ,  C07D401/06 ,  C07D403/06 ,  C07D405/12 ,  C07D413/06

CPC classification number: C07D231/56 ,  A61K31/404 ,  A61K31/416 ,  A61K31/437 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  C07D209/26 ,  C07D401/06 ,  C07D403/06 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04 ,  Y02A50/409

Abstract: The present invention relates to compounds according to Formula I and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.

公开(公告)号：US11352320B2

公开(公告)日：2022-06-07

申请号：US17057921

申请日：2019-05-28

Applicant: Merck Sharp & Dohme Corp.

Inventor： Shuwen He ,  Dane Clausen ,  Liangqin Guo ,  Yongxin Han ,  Xianhai Huang ,  Alexander Pasternak ,  Qinglin Pu ,  Dong Xiao ,  Li Xiao ,  Feng Ye ,  Hongjun Zhang

IPC: C07C13/06 ,  C07C233/65 ,  C07C233/80 ,  A61K31/166 ,  C07C271/14 ,  A61P35/00 ,  C07D213/74 ,  C07D237/34 ,  C07D239/42 ,  C07D239/94 ,  C07D241/20 ,  C07D471/04 ,  A61K45/06

Abstract: Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.

公开(公告)号：US11274111B2

公开(公告)日：2022-03-15

申请号：US16973623

申请日：2019-06-14

Applicant: Merck Sharp & Dohme Corp.

Inventor： Abdelghani Abe Achab ,  Jared N. Cumming ,  Christian Fischer ,  Symon Gathiaka ,  Charles A. Lesburg ,  Derun Li ,  Min Lu ,  Matthew J. Mitcheltree ,  Anandan Palani ,  Rachel L. Palte ,  David L. Sloman ,  Hongjun Zhang

IPC: C07F5/02 ,  C07K16/28

Abstract: Described herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. The compounds of Formula (I) act as arginase inhibitors and can be useful in preventing, treating or acting as a remedial agent for arginase-related diseases.