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    Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples
    3.
    发明授权
    Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples 有权

    公开(公告)号：US11041216B2

    公开(公告)日：2021-06-22

    申请号：US15361228

    申请日：2016-11-25

    申请人： Longhorn Vaccines and Diagnostics, LLC

    发明人： Jeffrey D. Fischer ,  Luke T. Daum ,  Gerald W. Fischer

    IPC分类号： C12Q1/68 ,  C12N15/10 ,  C12Q1/70 ,  C12Q1/689 ,  C12Q1/6806

    摘要： The invention is directed to compositions and methods for rapidly detecting, amplifying, and quantitating one or more pathogen-specific nucleic acids in a biological sample, and in particular, samples obtained from patients with sepsis. The invention also provides diagnostic kits containing specific amplification primers, and labeled detection probes that specifically bind to the amplification products obtained therefrom. The invention is also directed to detecting the quantity or ratio of genomic sequences and mRNA sequences of an individual suspected of being infected with an infectious agent over time to assess the progress of the infection over time. Also disclosed are compositions and methods for the isolation and characterization of nucleic acids that are specific to one or more pathogens, such as, for example, Influenza virus, Mycobacterium tuberculosis, Plasmodium, and/or HIV from a wide variety of samples including those of biological, environmental, clinical and/or veterinary origin.

    Immunogenic Antigens
    5.
    发明申请
    Immunogenic Antigens 有权

    公开(公告)号：US20220118079A1

    公开(公告)日：2022-04-21

    申请号：US17506237

    申请日：2021-10-20

    申请人： Longhorn Vaccines and Diagnostics, LLC

    发明人： Jeffrey D. Fischer ,  Clara J. Sei ,  Luke T. Daum ,  Gerald W. Fischer

    IPC分类号： A61K39/145 ,  A61K39/04 ,  A61K39/102 ,  A61P31/16

    摘要： The invention relates to composite antigens comprising an antigen obtained or derived from an antigenic epitope of one or more pathogens that induces an immune response in a mammal, an antigen obtained or derived from bacterial cell wall material that induces an immune response in a mammal such as LTA, PNG or LPS, and a T cell stimulating antigen such as CRM. Preferably the composite antigen comprises an immunogenic composition or a vaccine that is effective against the pathogen or can generate antibodies that can be collected that are protective against infection by the pathogen. In addition, the invention relates to vaccines comprising composite antigens and to method for treating and preventing an infection.

    Immunogenic Antigens
    6.
    发明公开
    Immunogenic Antigens 审中-公开

    公开(公告)号：US20230226166A1

    公开(公告)日：2023-07-20

    申请号：US18162032

    申请日：2023-01-31

    申请人： Longhorn Vaccines and Diagnostics, LLC

    发明人： Jeffrey D. Fischer ,  Clara J. Sei ,  Gerald W. Fischer

    IPC分类号： A61K39/145 ,  A61K39/04 ,  A61P31/16 ,  A61P31/06

    CPC分类号： A61K39/145 ,  A61K39/04 ,  A61P31/16 ,  A61P31/06 ,  A61K2039/525

    摘要： The invention relates to immunogenic compositions comprising an antigen obtained or derived from an antigenic epitope of one or more pathogens that induces an immune response in a mammal, an antigen obtained or derived from bacterial cell wall or viral material that induces an immune response in a mammal such as LTA, PNG or LPS, and a T cell stimulating antigen such as CRM. Preferably the immunogenic composition is a vaccine that is effective against a pathogenic infection or can generate antibodies that can be collected that are protective against infection by the pathogen. In addition, the invention relates to vaccines comprising antigens and to method for treating and preventing an infection.

    Immunogenic Antigens
    7.
    发明申请
    Immunogenic Antigens 有权

    公开(公告)号：US20220296696A1

    公开(公告)日：2022-09-22

    申请号：US17506254

    申请日：2021-10-20

    申请人： Longhorn Vaccines and Diagnostics, LLC

    发明人： Jeffrey D. Fischer ,  Clara J. Sei ,  Luke T. Daum ,  Gerald W. Fischer

    IPC分类号： A61K39/095 ,  A61K47/64 ,  A61K39/09 ,  A61K39/102 ,  A61P37/04 ,  A61K39/385 ,  A61K39/116

    摘要： The invention relates to composite antigens comprising an antigen obtained or derived from an antigenic epitope of one or more pathogens that induces an immune response in a mammal, an antigen obtained or derived from bacterial cell wall material that induces an immune response in a mammal such as LTA, PNG or LPS, and a T cell stimulating antigen such as CRM. Preferably the composite antigen comprises an immunogenic composition or a vaccine that is effective against the pathogen or can generate antibodies that can be collected that are protective against infection by the pathogen. In addition, the invention relates to vaccines comprising composite antigens and to method for treating and preventing an infection.

    Compositions and Methods for Detecting and Quantifying Nucleic Acid Sequences in Blood Samples
    8.
    发明申请
    Compositions and Methods for Detecting and Quantifying Nucleic Acid Sequences in Blood Samples 审中-公开
    用于检测和定量血液样品中核酸序列的组合物和方法

    公开(公告)号：US20170073738A1

    公开(公告)日：2017-03-16

    申请号：US15361228

    申请日：2016-11-25

    申请人： Longhorn Vaccines and Diagnostics, LLC

    发明人： Jeffrey D. Fischer ,  Luke T. Daum ,  Gerald W. Fischer

    IPC分类号： C12Q1/68 ,  C12Q1/70

    CPC分类号： C12Q1/689 ,  C12N15/1003 ,  C12Q1/6806 ,  C12Q1/701 ,  C12Q2600/16 ,  C12Q2600/166 ,  Y02A50/58 ,  C12Q2527/119 ,  C12Q2527/125 ,  C12Q2527/137 ,  C12Q2527/143

    摘要： The invention is directed to compositions and methods for rapidly detecting, amplifying, and quantitating one or more pathogen-specific nucleic acids in a biological sample, and in particular, samples obtained from patients with sepsis. The invention also provides diagnostic kits containing specific amplification primers, and labeled detection probes that specifically bind to the amplification products obtained therefrom. The invention is also directed to detecting the quantity or ratio of genomic sequences and mRNA sequences of an individual suspected of being infected with an infectious agent over time to assess the progress of the infection over time. Also disclosed are compositions and methods for the isolation and characterization of nucleic acids that are specific to one or more pathogens, such as, for example, Influenza virus, Mycobacterium tuberculosis, Plasmodium, and/or HIV from a wide variety of samples including those of biological, environmental, clinical and/or veterinary origin.

    摘要翻译： 本发明涉及用于快速检测，扩增和定量生物样品中的一种或多种病原体特异性核酸的组合物和方法，特别是从败血症患者获得的样品。 本发明还提供了包含特异性扩增引物的诊断试剂盒，以及特异性结合从其获得的扩增产物的标记检测探针。 本发明还涉及检测怀疑随时间感染的感染因子的个体的基因组序列和mRNA序列的数量或比例，以评估感染随时间的进展。 还公开了用于分离和表征一种或多种病原体特异性的核酸的组合物和方法，所述病原体例如来自多种样品的流感病毒，结核分枝杆菌，疟原虫和/或HIV的样品，包括 生物，环境，临床和/或兽医来源。