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    Methods for Improving Efficiency of Cell Electroporation Using Dielectrophoreses
    1.
    发明申请
    Methods for Improving Efficiency of Cell Electroporation Using Dielectrophoreses 审中-公开
    提高细胞电穿孔效率的方法

    公开(公告)号：US20090000948A1

    公开(公告)日：2009-01-01

    申请号：US12097409

    申请日：2007-01-04

    Applicant: Lei Wang ,  Lei Wang ,  Min Guo ,  Jing Cheng

    Inventor： Lei Wang ,  Lei Wang ,  Min Guo ,  Jing Cheng

    IPC: G01N27/26 ,  G01N27/00

    CPC classification number: C12N13/00 ,  C12M23/16 ,  C12M33/00 ,  C12M35/02

    Abstract: The present invention provides methods for enhancing the efficiency of cell electroporation using dielectrophoresis-assisted cell localization and uses thereof in a microfluidic biochip system. Cells are first subject to dielectrophoresis and localized to regions where the electric field intensity is high enough to render cells electroporated. The invention enhances the efficiency of in situ cell electroporation on a traditional microfluidic biochip.

    Abstract translation: 本发明提供使用介电电泳辅助细胞定位提高细胞电穿孔效率的方法及其在微流体生物芯片系统中的用途。 细胞首先进行介导电泳，并定位于电场强度足以使细胞电穿孔的区域。 本发明增强了传统微流体生物芯片上原位细胞电穿孔的效率。

    MULTI-CHANNEL CAPILLARY ELECTROPHORESIS MICROCHIPS AND USES THEREOF
    6.
    发明申请
    MULTI-CHANNEL CAPILLARY ELECTROPHORESIS MICROCHIPS AND USES THEREOF 审中-公开
    多通道毛细管电泳细胞及其用途

    公开(公告)号：US20090127114A1

    公开(公告)日：2009-05-21

    申请号：US12158489

    申请日：2006-12-22

    Applicant: Min Guo ,  Guibin Du ,  Guangsheng Gu ,  Wanli Xing ,  Jing Cheng

    Inventor： Min Guo ,  Guibin Du ,  Guangsheng Gu ,  Wanli Xing ,  Jing Cheng

    IPC: G01N27/447

    CPC classification number: G01N27/44791

    Abstract: A multi-channel capillary electrophoresis microchip for analysis of multiple samples comprising: at least two sample reservoirs, at least two sample channels corresponding to said sample reservoirs, a sample buffer reservoir, a sample waste reservoir, a separation buffer reservoir, a separation waste reservoir, a sample loading channel, and a separation channel, wherein each of said sample channels is connected at one end to said sample loading channel at a place between said sample buffer reservoir and said intersection of said sample loading channel and said separation channel, and the other end of each of said sample channels is connected to each of said sample reservoirs. A method of capillary electrophoresis separation for sequentially analysis of multiple samples.

    Abstract translation: 一种用于分析多个样品的多通道毛细管电泳微芯片，包括：至少两个样品储存器，对应于所述样品储存器的至少两个样品通道，样品缓冲液储存器，样品废物储存器，分离缓冲液储存器，分离废液储存器 ，样品加载通道和分离通道，其中每个所述样品通道在一端连接到所述样品缓冲液储存器和所述样品加载通道与所述分离通道的交叉点之间的位置处的所述样品加载通道，并且 每个所述样品通道的另一端连接到每个所述样品储存器。 毛细管电泳分离方法，用于顺序分析多个样品。

    Method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction
    8.
    发明申请
    Method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction 审中-公开
    杂交反应后用超声波洗涤固体底物的方法和装置

    公开(公告)号：US20060124152A1

    公开(公告)日：2006-06-15

    申请号：US10524903

    申请日：2002-12-10

    Applicant: Gang Li ,  Wanli Xing ,  Ruige Wu ,  Min Guo ,  Jing Cheng

    Inventor： Gang Li ,  Wanli Xing ,  Ruige Wu ,  Min Guo ,  Jing Cheng

    IPC: B08B3/10

    CPC classification number: B08B3/12 ,  C12Q1/6813 ,  C12Q2523/301

    Abstract: A method and apparatus for washing solid substrate with ultrasonic wave after hybridization reaction are provided. The method includes (1) putting the solid substrate into a container having a washing solution, on which the hybridization reaction has been completed, (2) using an ultrasonic generator to produce a certain strength of ultrasonic wave and transmit it into the washing solution, (3) washing the substrate by means of the cavitation effect being produced in the washing solution by the ultrasonic wave. Since the cavitation bubbles in the washing solution can produce intensive efflux and local microslipstream against the solid surface, evidently reducing the liquid surface tension and friction and enhance the liquid flow, non-specific adsorbate and deposit bound weakly on the solid substrate can be washed down rapidly.

    Abstract translation: 提供了一种用于在杂交反应之后用超声波洗涤固体底物的方法和装置。 该方法包括：（1）将固体基质置于具有杂交反应完成的洗涤液的容器中，（2）使用超声波发生器产生一定强度的超声波并将其输送到洗涤液中， （3）通过超声波在洗涤液中产生的空化作用洗涤基板。 由于洗涤液中的气穴气泡能够对固体表面产生强烈的流出和局部微滑流，明显降低了液面张力和摩擦力，增强了液体流动，固体基质上弱结合的非特异性吸附物和沉积物可以被冲洗掉 迅速

    Method for fluid transfer and the micro peristaltic pump
    9.
    发明授权
    Method for fluid transfer and the micro peristaltic pump 有权
    流体转移方法和微蠕动泵

    公开(公告)号：US08353685B2

    公开(公告)日：2013-01-15

    申请号：US10543619

    申请日：2003-07-14

    Applicant: Chengxun Liu ,  Min Guo ,  Jing Cheng

    Inventor： Chengxun Liu ,  Min Guo ,  Jing Cheng

    IPC: F04B17/00

    CPC classification number: F04B43/02 ,  F04B43/028 ,  F04B43/14

    Abstract: This invention relates generally to the field of peristaltic pump. In particular, the invention provides a peristaltic pump, which peristaltic pump comprises, inter alia, an actuating part, a cartridge part comprising at least three chambers and mechanisms for controlling movement of the actuating part to and from the cartridge part to control opening or closing of the inlet and outlet to the chamber(s).

    Abstract translation: 本发明一般涉及蠕动泵领域。 特别地，本发明提供了一种蠕动泵，蠕动泵尤其包括致动部件，包括至少三个腔室的药筒部分和用于控制致动部件到药筒部分和从药筒部分移动以控制打开或关闭的机构 的入口和出口到腔室。

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