公开(公告)号：US10246410B2

公开(公告)日：2019-04-02

申请号：US15529437

申请日：2015-12-03

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Wenjun Zhou ,  Kyle Gee ,  Yolanda Tennico ,  Peter Slade ,  Hee Chol Kang ,  Shaheer Khan ,  Brian Evans ,  James Stray

IPC: C07C309/47 ,  G01N33/58 ,  C07D311/84 ,  C07C309/51

Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.

公开(公告)号：US11535885B2

公开(公告)日：2022-12-27

申请号：US15733557

申请日：2019-03-01

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Khairuzzaman Bashar Mullah ,  Brian Evans ,  Scott C. Benson ,  Chu-An Chang ,  Xiongwei Yan

IPC: C12Q1/68 ,  C12Q1/6818 ,  C12Q1/686

Abstract: Disclosed is a probe for use in biological assays. The probe includes a fluorescent dye bound to a quencher compound through an oligonucleotide linker. Also disclosed are methods of using the probe, such as for a polymerase chain reaction (PCR), such as in a quantitative PCR reaction (qPCR), as well as kits including the probe.

公开(公告)号：US11046727B2

公开(公告)日：2021-06-29

申请号：US15682103

申请日：2017-08-21

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Tom Xu ,  Christopher Trinh ,  Carole Bornarth ,  Brian Evans ,  Mousumi Rath ,  Kathy Tran

IPC: C07H21/02 ,  C12Q1/6876 ,  C12N15/10 ,  C12Q1/6809 ,  C12Q1/6834

Abstract: Method and compositions and kits for isolation, identification, and quantification of miRNAs and other small RNAs, including but not limited to, siRNAs, mRNAs, and snRNAs are disclosed. Methods of diagnosing a disease or its progression are also disclosed.

公开(公告)号：US10793518B2

公开(公告)日：2020-10-06

申请号：US15894057

申请日：2018-02-12

Applicant: LIFE TECHNOLOGIES CORPORATION

Inventor： Wenjun Zhou ,  Kyle Gee ,  Yolanda Tennico ,  Peter Slade ,  Hee Chol Kang ,  Shaheer Khan ,  Brian Evans ,  James Stray

IPC: C07C309/47 ,  C07D311/84 ,  C07C309/51 ,  G01N33/58

Abstract: The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.