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    Catalyst systems, olefin polymerization catalyst components comprising at least an internal electron donor compound, and methods of making and using the same
    1.
    再颁专利
    Catalyst systems, olefin polymerization catalyst components comprising at least an internal electron donor compound, and methods of making and using the same 有权

    公开(公告)号：USRE48346E1

    公开(公告)日：2020-12-08

    申请号：US16400294

    申请日：2019-05-01

    Applicant: BRASKEM AMERICA, INC.

    Inventor： Binh Thanh Nguyen ,  Jonas Alves Fernandes

    IPC: C08F110/06 ,  C07D311/84

    Abstract: An olefin polymerization catalyst component comprising an internal electron donor compound shown in formula (I) below is provided in this disclosure: wherein X is O, S, NRa, PRb, or POORc, Ra is independently hydrogen, halogen, carbonyl hydrocarbon, linear or branched unsaturated or saturated alkyl hydrocarbon, cyclic, aromatic, or aliphatic hydrocarbon, Rb is independently hydrogen, halogen, carbonyl hydrocarbon, linear or branched unsaturated or saturated alkyl hydrocarbon, linear or branched unsaturated or saturated alkoxy hydrocarbon, cyclic, aromatic, or aliphatic hydrocarbon, Rc is independently hydrogen, carbonyl hydrocarbon, linear or branched unsaturated or saturated alkyl hydrocarbon, cyclic, aromatic, or aliphatic hydrocarbon, R1-R8 are identical or different hydrogen, halogen, linear or branched unsaturated or saturated C1-C30 alkyl, alone or in combination with C5-C30 substituted or unsubstituted 5-or 6-membered aliphatic or aromatic hydrocarbon rings, each of Ra, Rb, Rc, and/or R1-R8 are optionally substituted with halogen.

    Catalyst system, olefin polymerization catalyst components comprising at least an internal electron donor compound, and methods of making and using the same
    6.
    发明授权
    Catalyst system, olefin polymerization catalyst components comprising at least an internal electron donor compound, and methods of making and using the same 有权

    公开(公告)号：US09637575B2

    公开(公告)日：2017-05-02

    申请号：US14588379

    申请日：2014-12-31

    Applicant: W.R. Grace & Co.-Conn.

    Inventor： Binh Thanh Nguyen ,  Jonas Alves Fernandes

    IPC: C07D311/84 ,  C08F110/06

    CPC classification number: C08F110/06 ,  C07D311/84 ,  C08F2500/12 ,  C08F2500/15 ,  C08F4/651

    Abstract: An olefin polymerization catalyst component comprising an internal electron donor compound shown in formula (I) below is provided in this disclosure: wherein X is O, S, NRa, PRb, or POORc, Ra is independently hydrogen, halogen, carbonyl hydrocarbon, linear or branched unsaturated or saturated alkyl hydrocarbon, cyclic, aromatic, or aliphatic hydrocarbon, Rb is independently hydrogen, halogen, carbonyl hydrocarbon, linear or branched unsaturated or saturated alkyl hydrocarbon, linear or branched unsaturated or saturated alkoxy hydrocarbon, cyclic, aromatic, or aliphatic hydrocarbon, Rc is independently hydrogen, carbonyl hydrocarbon, linear or branched unsaturated or saturated alkyl hydrocarbon, cyclic, aromatic, or aliphatic hydrocarbon, R1-R8 are identical or different hydrogen, halogen, linear or branched unsaturated or saturated C1-C30 alkyl, alone or in combination with C5-C30 substituted or unsubstituted 5-or 6-membered aliphatic or aromatic hydrocarbon rings, each of Ra, Rb, Rc, and/or R1-R8 are optionally substituted with halogen.

    Amides of pyrrolidinoethylamine which can be used in lung therapy
    9.
    发明授权
    Amides of pyrrolidinoethylamine which can be used in lung therapy 失效
    可用于肺部治疗的吡咯烷基乙胺的酰胺

    公开(公告)号：US4192883A

    公开(公告)日：1980-03-11

    申请号：US931489

    申请日：1978-08-07

    Applicant: Henri Cousse ,  Bernard Bonnaud ,  Jean-Pierre Tarayre ,  Silvano Casadio

    Inventor： Henri Cousse ,  Bernard Bonnaud ,  Jean-Pierre Tarayre ,  Silvano Casadio

    IPC: C07D279/30 ,  C07D295/13 ,  C07D311/12 ,  C07D311/84 ,  A61K31/40 ,  C07D295/14

    CPC classification number: C07D295/13 ,  C07D279/30 ,  C07D311/12 ,  C07D311/84

    Abstract: New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith.In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic,.alpha.-phenyl-.alpha.-ethylacetic, diphenylacetic, benzilic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 10-phenothiazinecarboxylic, benzoic, halobenzoic, 3-coumarincarboxylic, 9-xanthenecarboxylic, salicylic, cresotic, halocresotic, lower-alkoxybenzoic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, cinnamic, or 9-fluorene carboxylic acid, and wherein R'H represents an inorganic or organic acid, and wherein R may be, for example, a substituted aromatic ring of the formula: ##STR3## wherein R.sub.1 and R.sub.2 may independently be lower-alkyl, lower-alkoxy, hydrogen, lower-alkenyloxy, or lower-alkynyloxy, and X may be hydrogen or halogen.Medicaments containing these active principles may be used, inter alia, in the treatment of coughs and respiratory complaints.

    Abstract translation: 新的化合物，它们是吡咯烷基乙胺酰胺，其形式为游离碱和盐，它们可用作镇咳药，其药物组合物及其处理方法。 以它们的盐的形式，化合物具有下式：其中是苯乙酸，α-苯基-α-乙基乙酸，二苯基乙酸，苯偶酰，α-低级烷氧基-α，α 二苯乙酸，10-吩噻嗪羧酸，苯甲酸，卤代苯甲酸，3-香豆素羧酸，9-呫吨羧酸，水杨酸，间歇，卤代，低级烷氧基苯甲酸，苯氧基乙酸，苯氧基异丁酰，卤代苯氧基异丁酸，肉桂酸或9-芴羧酸，其中R'H代表 无机或有机酸，其中R可以是例如下式的取代芳环：其中R 1和R 2可以独立地为低级烷基，低级烷氧基，氢，低级烯氧基或低级 - 炔氧基，X可以是氢或卤素。 含有这些积极原则的药物，除其他外，可用于治疗咳嗽和呼吸道疾病。

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