Invention Grant
- Patent Title: Amides of pyrrolidinoethylamine which can be used in lung therapy
- Patent Title (中): 可用于肺部治疗的吡咯烷基乙胺的酰胺
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Application No.: US931489Application Date: 1978-08-07
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Publication No.: US4192883APublication Date: 1980-03-11
- Inventor: Henri Cousse , Bernard Bonnaud , Jean-Pierre Tarayre , Silvano Casadio
- Applicant: Henri Cousse , Bernard Bonnaud , Jean-Pierre Tarayre , Silvano Casadio
- Applicant Address: FRX
- Assignee: Pierre Fabre, S.A.
- Current Assignee: Pierre Fabre, S.A.
- Current Assignee Address: FRX
- Priority: FRX7610754 19760409
- Main IPC: C07D279/30
- IPC: C07D279/30 ; C07D295/13 ; C07D311/12 ; C07D311/84 ; A61K31/40 ; C07D295/14
Abstract:
New chemical compounds, which are pyrrolidinoethylamine amides, in the form of free bases and salts thereof, which are useful as antitussives, pharmaceutical compositions thereof, and method of treating therewith.In the form of their salts, the compounds have the formula: ##STR1## wherein ##STR2## is an acyl radical of a phenylacetic,.alpha.-phenyl-.alpha.-ethylacetic, diphenylacetic, benzilic, .alpha.-lower-alkoxy-.alpha.,.alpha.-diphenylacetic, 10-phenothiazinecarboxylic, benzoic, halobenzoic, 3-coumarincarboxylic, 9-xanthenecarboxylic, salicylic, cresotic, halocresotic, lower-alkoxybenzoic, phenoxyacetic, phenoxyisobutyric, halophenoxyisobutyric, cinnamic, or 9-fluorene carboxylic acid, and wherein R'H represents an inorganic or organic acid, and wherein R may be, for example, a substituted aromatic ring of the formula: ##STR3## wherein R.sub.1 and R.sub.2 may independently be lower-alkyl, lower-alkoxy, hydrogen, lower-alkenyloxy, or lower-alkynyloxy, and X may be hydrogen or halogen.Medicaments containing these active principles may be used, inter alia, in the treatment of coughs and respiratory complaints.
Public/Granted literature
- USD346501S Chair Public/Granted day:1994-05-03
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