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公开(公告)号：US10246410B2
公开(公告)日：2019-04-02
申请号：US15529437
申请日：2015-12-03
发明人： Wenjun Zhou , Kyle Gee , Yolanda Tennico , Peter Slade , Hee Chol Kang , Shaheer Khan , Brian Evans , James Stray
IPC分类号： C07C309/47 , G01N33/58 , C07D311/84 , C07C309/51
摘要： The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.
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2.发明授权公开(公告)号：US10908164B2
公开(公告)日：2021-02-02
申请号：US15460491
申请日：2017-03-16
发明人： Peter Slade
IPC分类号： G01N33/68 , G01N27/447 , C12Q1/34
摘要： An apparatus for glycan analysis is disclosed. The apparatus includes a plurality of loading wells adapted to receive a plurality of samples; a plurality of capillaries arranged in correspondence with the loading wells, each of the capillaries including a first portion including a stacking gel and a second portion including a resolving gel; and a plurality of eluting wells arranged in correspondence with the capillaries and adapted to receive a portion of the samples having traversed the capillaries.
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公开(公告)号：US10793518B2
公开(公告)日：2020-10-06
申请号：US15894057
申请日：2018-02-12
发明人： Wenjun Zhou , Kyle Gee , Yolanda Tennico , Peter Slade , Hee Chol Kang , Shaheer Khan , Brian Evans , James Stray
IPC分类号： C07C309/47 , C07D311/84 , C07C309/51 , G01N33/58
摘要： The present disclosure is directed dye compounds containing a hydrazinyl substituent and optionally, one or more negatively charged groups, such as sulfonate, phosphate, phosphonate, and/or carboxylate groups and dye compounds containing an aminooxy substitutent. The compounds are useful in the detection of analytes containing aldehyde and ketone groups, including, for example, glycans.
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4.发明申请公开(公告)号：US20170248606A1
公开(公告)日：2017-08-31
申请号：US15460491
申请日：2017-03-16
发明人： Peter Slade
IPC分类号： G01N33/68 , G01N27/447
CPC分类号： G01N33/6842 , C12Q1/34 , G01N27/44726 , G01N27/44782 , G01N27/44791 , G01N33/6803 , G01N2333/924 , G01N2400/00 , G01N2400/38
摘要： An apparatus for glycan analysis is disclosed. The apparatus includes a plurality of loading wells adapted to receive a plurality of samples; a plurality of capillaries arranged in correspondence with the loading wells, each of the capillaries including a first portion including a stacking gel and a second portion including a resolving gel; and a plurality of eluting wells arranged in correspondence with the capillaries and adapted to receive a portion of the samples having traversed the capillaries.
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