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公开(公告)号：US20210355106A1
公开(公告)日：2021-11-18
申请号：US17282898
申请日：2019-10-18
发明人： Csaba WÉBER , András KOTSCHY , Attila VASAS , Árpád KISS , Balázs MOLNÁR , Andrea FIUMANA , Alba MACIAS , James Brooke MURRAY , Didier DEMARLES , Lisa IVANSCHITZ , Olivier GENESTE , Kristóf HEGEDÜS , Péter SPRÁNITZ , Tibor SOÓS
IPC分类号： C07D401/14 , A61P35/00 , A61K45/06 , A61K31/513 , C07D417/14 , A61K31/517 , C07D409/14 , C07D405/14
摘要： wherein R1, R2, R3, R4, R5, n and Q are as defined in the description.
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公开(公告)号：US20190144449A1
公开(公告)日：2019-05-16
申请号：US16306941
申请日：2017-06-09
发明人： András KOTSCHY , Csaba WÉBER , Attila VASAS , Balázs MOLNÁR , Árpád KISS , Alba MACIAS , James Brooke MURRAY , Elodie LEWKOWICZ , Olivier GENESTE , Maïa CHANRION , Didier DEMARLES , Lisa IVANSCHITZ
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D495/04 , A61K31/519 , A61K31/522
摘要： Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
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3.发明申请公开(公告)号：US20190144448A1
公开(公告)日：2019-05-16
申请号：US16306933
申请日：2017-06-09
发明人： András KOTSCHY , Csaba WÉBER , Attila VASAS , Balázs MOLNÁR , Árpád KISS , Alba MACIAS , James Brooke MURRAY , Elodie LEWKOWICZ , Olivier GENESTE , Maïa CHANRION , Didier DEMARLES
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , A61P37/02
摘要： Compounds of formula (I): wherein R1, R2, R3, n and W are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
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4.发明公开公开(公告)号：US20240245699A1
公开(公告)日：2024-07-25
申请号：US18591522
申请日：2024-02-29
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K9/20 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
摘要： Compounds of formula (I):
wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.
Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.-
![6,7-DIHYDRO-5H-PYRIDO[2,3-C]PYRIDAZINE DERIVATIVES AND RELATED COMPOUNDS AS BCL-XL PROTEIN INHIBITORS AND PRO-APOPTOTIC AGENTS FOR TREATING CANCER](/abs-image/US/2022/11/17/US20220363677A1/abs.jpg.150x150.jpg)
公开(公告)号：US20220363677A1
公开(公告)日：2022-11-17
申请号：US17630673
申请日：2020-07-28
发明人： Tibor NOVÁK , James Edward Paul DAVIDSON , Attila PACZAL , Jérôme-Benoît STARCK , András KOTSCHY , James Brooke MURRAY , Simon BEDFORD , Maïa CHANRION , Frédéric COLLAND , Mark Philip DODSWORTH , Andràs HERNER , Ana Leticia MARAGNO , Emma SANDERS , Mátyás Pál TIMÁRI , Paul WEBB
IPC分类号： C07D417/14 , C07D471/04 , C07D487/04 , A61P35/02 , A61P35/00
摘要： Compounds of formula (I): wherein Het, Het1, Het2, A4, A5, Z1, R1, R2 and R3 are as defined in the description. Medicaments.
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公开(公告)号：US20220289734A1
公开(公告)日：2022-09-15
申请号：US17630655
申请日：2020-07-28
发明人： James Edward Paul DAVIDSON , Tibor NOVÁK , Attila PACZAL , András KOTSCHY , Jérôme-Benoît STARCK , James Brooke MURRAY , Simon BEDFORD , Maïa CHANRION , Frédéric COLLAND , Patrice DESOS , Mark Philip DODSWORTH , Petra DUNKEL , Andràs HERNER , Zoltán MADARÁSZ , Ana Leticia MARAGNO , Márk MOLNÁR , Miklós NYERGES , Rachel Jane PARSONS , Monika RUDASOVÁ , Ágnes STROFEK , Marianna SZIGETI , Mátyás Pál TIMÁRI , Paul WEBB
IPC分类号： C07D417/14 , A61K31/501 , A61P35/00 , A61K45/06 , C07D417/12
摘要： Compounds of formula (I): wherein Het1, Het2, R1, R2 and R3 are as defined in the description.
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7.发明申请公开(公告)号：US20180258098A1
公开(公告)日：2018-09-13
申请号：US15738186
申请日：2016-06-22
发明人： Balazs BALINT , Márton CSÉKEI , Zoltán SZABÓ , Zoltan SZLAVIK , András KOTSCHY , Maia CHANRION , Olivier GENESTE , I-Jen CHEN , James Edward Paul DAVIDSON , James Brooke MURRAY , Szabolcs SIPOS , Levente ONDI , Ágnes PROSZENYÁK
IPC分类号： C07D495/04 , C07D491/048 , C07D487/04 , C07D471/04 , C07D409/12 , C07D405/12 , C07D405/04 , C07D403/12 , C07D333/56 , C07D307/81 , C07D307/80 , C07D209/12 , A61P35/02
CPC分类号： C07D495/04 , A61K45/06 , A61K2300/00 , A61P35/02 , C07D209/12 , C07D307/80 , C07D307/81 , C07D333/56 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048
摘要： Compounds of formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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8.发明公开公开(公告)号：US20240150293A1
公开(公告)日：2024-05-09
申请号：US18262231
申请日：2022-01-11
发明人： Stephen STOKES , Simon BEDFORD , l-Jen CHEN , James Edward Paul DAVIDSON , Nicholas DAVIES , Christopher John GRAHAM , Sean Martin MCKENNA , Johannes W.G. MEISSNER , James Brooke MURRAY , Rachel Jane PARSONS , Stuart RAY , Emma SANDERS , Claire Louise WALMSLEY , Paul Andrew BROUGH , András KOTSCHY , Ágnes PROSZENYÁK , Ádám SINAI , Balázs Károly BÁLINT , Márton CSÉKEI , Márton ZWILLINGER , Rita GARAMVÖLGYI , Szabolcs SIPOS , Vilibald KUN , Zoltán SZABÓ , Maïa CHANRION , Francesca ROCCHETTI , Frédéric COLLAND , Ana Leticia MARAGNO , Laura BRESSON
IPC分类号： C07D215/233 , A61K45/06 , A61P35/00 , C07C229/50 , C07D317/70 , C07D401/12 , C07D405/10 , C07D491/056
CPC分类号： C07D215/233 , A61K45/06 , A61P35/00 , C07C229/50 , C07D317/70 , C07D401/12 , C07D405/10 , C07D491/056
摘要： Compounds of Formula (I):
wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.-
9.发明申请公开(公告)号：US20210290631A1
公开(公告)日：2021-09-23
申请号：US17341751
申请日：2021-06-08
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14
摘要： wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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10.发明申请公开(公告)号：US20200261464A1
公开(公告)日：2020-08-20
申请号：US16865855
申请日：2020-05-04
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , C07D498/14 , C07D491/107 , A61K31/506 , A61K31/496 , C07D498/04 , C07D491/10 , C07D471/04 , C07D401/10 , C07D405/14 , C07D401/14 , A61K9/20 , A61K31/5377 , A61K31/4725 , A61K45/06
摘要： Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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