专利检索 ap:("LES LABORATOIRES SERVIER" OR "VERNALIS (R&D) LTD") AND inv:"Jean-Michel HENLIN" 第 1 页

1.

发明公开
PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开

公开(公告)号：US20240245699A1

公开(公告)日：2024-07-25

申请号：US18591522

申请日：2024-02-29

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND

IPC分类号： A61K31/5383 , A61K9/20 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14

CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14

摘要： Compounds of formula (I):

wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.
Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

2.

发明申请
PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权

公开(公告)号：US20210290631A1

公开(公告)日：2021-09-23

申请号：US17341751

申请日：2021-06-08

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND

IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14

摘要： wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

3.

发明申请
PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开

公开(公告)号：US20200261464A1

公开(公告)日：2020-08-20

申请号：US16865855

申请日：2020-05-04

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND

IPC分类号： A61K31/5383 , C07D498/14 , C07D491/107 , A61K31/506 , A61K31/496 , C07D498/04 , C07D491/10 , C07D471/04 , C07D401/10 , C07D405/14 , C07D401/14 , A61K9/20 , A61K31/5377 , A61K31/4725 , A61K45/06

摘要： Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

4.

发明申请
PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权
标题翻译：磷酸盐化合物，其制备方法和含有它们的药物组合物

公开(公告)号：US20150313923A1

公开(公告)日：2015-11-05

申请号：US14800871

申请日：2015-07-16

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN

IPC分类号： A61K31/675 , A61N5/10 , A61K45/06

CPC分类号： A61K31/675 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07F9/09 , C07F9/65583 , C07F9/6561

摘要： Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

摘要翻译： 式（I）化合物：其中X，Y，A1，A2，Ra，Rb，Rc，Rd，R3，R4，T和R5如说明书中所定义。含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。

5.

发明申请
INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权

公开(公告)号：US20180186771A1

公开(公告)日：2018-07-05

申请号：US15906389

申请日：2018-02-27

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Guillaume DE NANTEUIL , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN

IPC分类号： C07D401/14 , A61K9/20 , C07D519/00 , A61K31/475 , C07D471/04 , A61K31/5377 , A61N5/10 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D487/04 , A61K31/4985

摘要： Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

6.

发明申请
INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：吲哚化合物，其制备方法及含有它们的药物组合物

公开(公告)号：US20150313911A1

公开(公告)日：2015-11-05

申请号：US14799840

申请日：2015-07-15

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Thierry LE DIGUARHER , Patrick CASARA , Jérôme-Benoît STARCK , Jean-Michel HENLIN , James Edward Paul DAVIDSON , James Brooke MURRAY , Christopher John GRAHAM , I-Jen CHEN , Olivier GENESTE , John HICKMAN , Stéphane DEPIL , Arnaud LE TIRAN , Miklos NYERGES , Guillaume DE NANTEUIL

IPC分类号： A61K31/553 , A61K31/496 , A61K31/4725 , A61N5/10 , A61K31/55 , A61K45/06 , A61K31/541 , A61K31/5377 , A61K31/5383

CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04

摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

摘要翻译： 式（I）化合物：其中R a，R b，R c，R d，R 1，R 2，R 3，R 4，R 5，X，Y和Het如说明书中所定义。含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。

7.

发明申请
PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：吡咯化合物，其制备方法及含有它们的药物组合物

公开(公告)号：US20150313907A1

公开(公告)日：2015-11-05

申请号：US14797532

申请日：2015-07-13

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , Janos TATAI , Miklos NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND

IPC分类号： A61K31/5377 , A61K31/4725 , A61K45/06

CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00

摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.

摘要翻译： 式（I）化合物：其中A1，A2，Ra，Rb，Rc，Rd，R3，R4，R5和T如说明书中所定义。含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。