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1.发明公开公开(公告)号：US20240245699A1
公开(公告)日：2024-07-25
申请号：US18591522
申请日：2024-02-29
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K9/20 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
摘要： Compounds of formula (I):
wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.
Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.-
2.发明申请PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开吡咯化合物，其制备方法及含有它们的药物组合物公开(公告)号：US20150313907A1
公开(公告)日：2015-11-05
申请号：US14797532
申请日：2015-07-13
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , Janos TATAI , Miklos NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5377 , A61K31/4725 , A61K45/06
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中A1，A2，Ra，Rb，Rc，Rd，R3，R4，R5和T如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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3.发明申请公开(公告)号：US20150031648A1
公开(公告)日：2015-01-29
申请号：US14337577
申请日：2014-07-22
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN
IPC分类号： C07F9/6561 , A61N5/10 , C07F9/6558 , A61K31/675 , A61K45/06
CPC分类号： A61K31/675 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07F9/09 , C07F9/65583 , C07F9/6561
摘要： Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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4.发明申请公开(公告)号：US20200262816A1
公开(公告)日：2020-08-20
申请号：US16865799
申请日：2020-05-04
发明人： James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Claire WALMSLEY , Mark DODSWORTH , Johannes W.G. MEISSNER , Paul BROUGH , lmre FEJES , János TATAI , Miklós NYERGES , András KOTSCHY , Zoltán SZLÁVIK , Olivier GENESTE , Arnaud LE TIRAN , Thierry LE DIGUARHER , Jean-Michel HENLIN , Jérôme-Benoît STARCK , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL
IPC分类号： C07D401/14 , C07F9/6561 , C07D417/14 , A61N5/10 , A61K45/06 , A61K31/675 , A61K31/5377 , A61K31/497 , A61K31/496 , C07D471/04 , C07D409/14 , A61K31/4725 , C07D405/14
摘要： Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p′, q, and q′ are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.
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5.发明申请公开(公告)号：US20150031673A1
公开(公告)日：2015-01-29
申请号：US14336311
申请日：2014-07-21
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , Janos TATAI , Miklos NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： C07D491/107 , A61K31/4725 , A61K31/496 , C07D401/10 , A61K45/06 , C07D405/14 , A61K31/506 , C07D471/04 , C07D498/14 , A61K31/5383 , C07D401/14 , A61K31/5377
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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6.发明申请公开(公告)号：US20210290631A1
公开(公告)日：2021-09-23
申请号：US17341751
申请日：2021-06-08
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14
摘要： wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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7.发明申请公开(公告)号：US20200261464A1
公开(公告)日：2020-08-20
申请号：US16865855
申请日：2020-05-04
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , C07D498/14 , C07D491/107 , A61K31/506 , A61K31/496 , C07D498/04 , C07D491/10 , C07D471/04 , C07D401/10 , C07D405/14 , C07D401/14 , A61K9/20 , A61K31/5377 , A61K31/4725 , A61K45/06
摘要： Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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8.发明申请PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权磷酸盐化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20150313923A1
公开(公告)日：2015-11-05
申请号：US14800871
申请日：2015-07-16
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN
IPC分类号： A61K31/675 , A61N5/10 , A61K45/06
CPC分类号： A61K31/675 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07F9/09 , C07F9/65583 , C07F9/6561
摘要： Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中X，Y，A1，A2，Ra，Rb，Rc，Rd，R3，R4，T和R5如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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