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1.发明申请公开(公告)号：US20200253993A1
公开(公告)日：2020-08-13
申请号：US16757052
申请日：2018-10-24
发明人： Jérôme-Benoît STARCK , Didier DURAND , I-Jen CHEN , Arnaud LE TIRAN , Jean-Claude ORTUNO , Miklós NYERGES , Melinda LIGETI , Imre FEJES
IPC分类号： A61K31/675 , A61K45/06 , C07F9/6533 , C07D498/18 , C07D498/22 , A61K31/5377 , A61K31/4748 , A61P35/02
摘要： Compound of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, X, Y and G are as defined in the description, and their use in the manufacture of medicaments.
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2.发明申请公开(公告)号：US20170143746A1
公开(公告)日：2017-05-25
申请号：US15425119
申请日：2017-02-06
发明人： Arnaud LE TIRAN , Thierry Le Diguarher , Jérôme-Benoit Starck , Jean-Michel Henlin , Anne-Francoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen
IPC分类号： A61K31/675
CPC分类号： A61K31/675 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07F9/09 , C07F9/65583 , C07F9/6561
摘要： Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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3.发明公开公开(公告)号：US20240245699A1
公开(公告)日：2024-07-25
申请号：US18591522
申请日：2024-02-29
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K9/20 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
摘要： Compounds of formula (I):
wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.
Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.-
公开(公告)号：US20180186771A1
公开(公告)日：2018-07-05
申请号：US15906389
申请日：2018-02-27
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Guillaume DE NANTEUIL , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN
IPC分类号： C07D401/14 , A61K9/20 , C07D519/00 , A61K31/475 , C07D471/04 , A61K31/5377 , A61N5/10 , A61K31/4709 , A61K31/4725 , A61K45/06 , C07D487/04 , A61K31/4985
摘要： Compounds of formula (I) wherein Ra, Rb, Rc, Rd, T, R3, R4, R5, X, Y and Het are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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5.发明申请INDOLIZINE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开吲哚化合物，其制备方法及含有它们的药物组合物公开(公告)号：US20150313911A1
公开(公告)日：2015-11-05
申请号：US14799840
申请日：2015-07-15
发明人： Thierry LE DIGUARHER , Patrick CASARA , Jérôme-Benoît STARCK , Jean-Michel HENLIN , James Edward Paul DAVIDSON , James Brooke MURRAY , Christopher John GRAHAM , I-Jen CHEN , Olivier GENESTE , John HICKMAN , Stéphane DEPIL , Arnaud LE TIRAN , Miklos NYERGES , Guillaume DE NANTEUIL
IPC分类号： A61K31/553 , A61K31/496 , A61K31/4725 , A61N5/10 , A61K31/55 , A61K45/06 , A61K31/541 , A61K31/5377 , A61K31/5383
CPC分类号： A61K31/5377 , A61K31/4725 , A61K31/475 , A61K31/496 , A61K31/5383 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61N5/10 , A61N5/1001 , C07D207/30 , C07D211/06 , C07D211/80 , C07D471/00 , C07D471/04 , C07D487/04 , C07D491/052 , C07D498/04
摘要： Compounds of formula (I): wherein Ra, Rb, Rc, Rd, R1, R2, R3, R4, R5, X, Y and Het are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中R a，R b，R c，R d，R 1，R 2，R 3，R 4，R 5，X，Y和Het如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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6.发明申请PYRROLE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开吡咯化合物，其制备方法及含有它们的药物组合物公开(公告)号：US20150313907A1
公开(公告)日：2015-11-05
申请号：US14797532
申请日：2015-07-13
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , Janos TATAI , Miklos NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5377 , A61K31/4725 , A61K45/06
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14 , A61K2300/00
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中A1，A2，Ra，Rb，Rc，Rd，R3，R4，R5和T如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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7.发明申请公开(公告)号：US20150031648A1
公开(公告)日：2015-01-29
申请号：US14337577
申请日：2014-07-22
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN
IPC分类号： C07F9/6561 , A61N5/10 , C07F9/6558 , A61K31/675 , A61K45/06
CPC分类号： A61K31/675 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07F9/09 , C07F9/65583 , C07F9/6561
摘要： Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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8.发明申请公开(公告)号：US20210290631A1
公开(公告)日：2021-09-23
申请号：US17341751
申请日：2021-06-08
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14
摘要： wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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9.发明申请公开(公告)号：US20200261464A1
公开(公告)日：2020-08-20
申请号：US16865855
申请日：2020-05-04
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , C07D498/14 , C07D491/107 , A61K31/506 , A61K31/496 , C07D498/04 , C07D491/10 , C07D471/04 , C07D401/10 , C07D405/14 , C07D401/14 , A61K9/20 , A61K31/5377 , A61K31/4725 , A61K45/06
摘要： Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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10.发明申请公开(公告)号：US20190192528A1
公开(公告)日：2019-06-27
申请号：US16271171
申请日：2019-02-08
发明人： Arnaud LE TIRAN , Thierry Le Diguarher , Jérôme-Benoît Starck , Jean-Michel Henlin , Anne-Françoise Guillouzic , Guillaume De Nanteuil , Olivier Geneste , Imre Fejes , János Tatai , Miklós Nyerges , James Edward Paul Davidson , James Brooke Murray , I-Jen Chen , Didier Durand
IPC分类号： A61K31/5383 , A61K31/5377 , A61K31/4725 , A61K45/06 , C07D491/107 , A61K9/20 , C07D498/04 , A61K31/506 , C07D471/04 , C07D401/10 , C07D405/14 , C07D401/14 , C07D498/14 , A61K31/496 , C07D491/10
摘要： Compounds of formula (I): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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