公开(公告)号：US20240150293A1

公开(公告)日：2024-05-09

申请号：US18262231

申请日：2022-01-11

申请人： LES LABORATOIRES SERVIER ,  VERNALIS (R&D) LTD

发明人： Stephen STOKES ,  Simon BEDFORD ,  l-Jen CHEN ,  James Edward Paul DAVIDSON ,  Nicholas DAVIES ,  Christopher John GRAHAM ,  Sean Martin MCKENNA ,  Johannes W.G. MEISSNER ,  James Brooke MURRAY ,  Rachel Jane PARSONS ,  Stuart RAY ,  Emma SANDERS ,  Claire Louise WALMSLEY ,  Paul Andrew BROUGH ,  András KOTSCHY ,  Ágnes PROSZENYÁK ,  Ádám SINAI ,  Balázs Károly BÁLINT ,  Márton CSÉKEI ,  Márton ZWILLINGER ,  Rita GARAMVÖLGYI ,  Szabolcs SIPOS ,  Vilibald KUN ,  Zoltán SZABÓ ,  Maïa CHANRION ,  Francesca ROCCHETTI ,  Frédéric COLLAND ,  Ana Leticia MARAGNO ,  Laura BRESSON

IPC分类号： C07D215/233 ,  A61K45/06 ,  A61P35/00 ,  C07C229/50 ,  C07D317/70 ,  C07D401/12 ,  C07D405/10 ,  C07D491/056

CPC分类号： C07D215/233 ,  A61K45/06 ,  A61P35/00 ,  C07C229/50 ,  C07D317/70 ,  C07D401/12 ,  C07D405/10 ,  C07D491/056

摘要： Compounds of Formula (I):




wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.