专利检索 ap:("LES LABORATOIRES SERVIER" OR "VERNALIS (R&D) LTD.") AND inv:"Attila PACZAL" 第 1 页

1.

发明申请
HYDROXYESTER DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开

公开(公告)号：US20180170947A1

公开(公告)日：2018-06-21

申请号：US15737479

申请日：2016-06-22

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Zoltan SZLAVIK , András KOTSCHY , Maïa CHANRION , Didier DEMARLES , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , Szabolcs SIPOS , Attila PACZAL , Balazs BALINT

IPC分类号： C07D495/04 , A61K45/06 , A61K31/519 , A61P35/00

CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , A61P35/00

摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R13, Ra, Rb, A and n are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.

2.

发明申请
AMINOACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开

公开(公告)号：US20190031675A1

公开(公告)日：2019-01-31

申请号：US15737783

申请日：2016-06-22

申请人： LES LABORATOIRES SERVIER , Vernalis (R&D) LTD.

发明人： Zoltan SZLAVIK , Zoltán SZABÓ , Márton CSÉKEI , Attila PACZAL , András KOTSCHY , Alain BRUNO , Olivier GENESTE , I-Jen CHEN , James Edward Paul DAVIDSON , James Brooke MURRAY , Levente ONDI , Gábor RADICS , Szabolcs SIPOS , Ágnes PROSZENYÁK , Françoise PERRON-SIERRA , Balázs BÁLINT

IPC分类号： C07D495/04 , A61P35/00 , A61P37/00

CPC分类号： C07D495/04 , A61P35/00 , A61P37/00

摘要： Compounds of formula (I): wherein R1, R2, R5, R6, R7, R12, X, Y, A, E and n are as defined in the description.Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.

3.

发明申请
6,7-DIHYDRO-5H-PYRIDO[2,3-C]PYRIDAZINE DERIVATIVES AND RELATED COMPOUNDS AS BCL-XL PROTEIN INHIBITORS AND PRO-APOPTOTIC AGENTS FOR TREATING CANCER 有权

公开(公告)号：US20220363677A1

公开(公告)日：2022-11-17

申请号：US17630673

申请日：2020-07-28

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD.

发明人： Tibor NOVÁK , James Edward Paul DAVIDSON , Attila PACZAL , Jérôme-Benoît STARCK , András KOTSCHY , James Brooke MURRAY , Simon BEDFORD , Maïa CHANRION , Frédéric COLLAND , Mark Philip DODSWORTH , Andràs HERNER , Ana Leticia MARAGNO , Emma SANDERS , Mátyás Pál TIMÁRI , Paul WEBB

IPC分类号： C07D417/14 , C07D471/04 , C07D487/04 , A61P35/02 , A61P35/00

摘要： Compounds of formula (I): wherein Het, Het1, Het2, A4, A5, Z1, R1, R2 and R3 are as defined in the description. Medicaments.

4.

发明申请
3,6-DIAMINO-PYRIDAZIN-3-YL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS 有权

公开(公告)号：US20220289734A1

公开(公告)日：2022-09-15

申请号：US17630655

申请日：2020-07-28

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD.

发明人： James Edward Paul DAVIDSON , Tibor NOVÁK , Attila PACZAL , András KOTSCHY , Jérôme-Benoît STARCK , James Brooke MURRAY , Simon BEDFORD , Maïa CHANRION , Frédéric COLLAND , Patrice DESOS , Mark Philip DODSWORTH , Petra DUNKEL , Andràs HERNER , Zoltán MADARÁSZ , Ana Leticia MARAGNO , Márk MOLNÁR , Miklós NYERGES , Rachel Jane PARSONS , Monika RUDASOVÁ , Ágnes STROFEK , Marianna SZIGETI , Mátyás Pál TIMÁRI , Paul WEBB

IPC分类号： C07D417/14 , A61K31/501 , A61P35/00 , A61K45/06 , C07D417/12

摘要： Compounds of formula (I): wherein Het1, Het2, R1, R2 and R3 are as defined in the description.

5.

发明申请
AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开

公开(公告)号：US20190031677A1

公开(公告)日：2019-01-31

申请号：US16069891

申请日：2016-12-19

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Attila PACZAL , Zoltán SZLÁVIK , András KOTSCHY , Maïa CHANRION , Ana Leticia MARAGNO , Olivier GENESTE , Didier DEMARLES , Balázs BÁLINT , Szabolcs SIPOS

IPC分类号： C07D495/04 , A61P35/02

摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6 and Y are as defined in the description. Medicaments.

6.

发明申请
HYDROXYACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开

公开(公告)号：US20180185369A1

公开(公告)日：2018-07-05

申请号：US15738601

申请日：2016-06-22

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： Zoltán SZLÁVIK , Attila PACZAL , Balázs BÁLINT , András KOTSCHY , Maïa CHANRION , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , Szabolcs SIPOS , Ágnes PROSZENYÁK

IPC分类号： A61K31/519 , A61K31/381 , A61K31/215 , A61P35/00

CPC分类号： A61K31/519 , A61K31/215 , A61K31/381 , A61P35/00 , C07D495/04

摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, A and n are as defined in the description.

7.

发明申请
THIENOPYRIMIDINE DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开

公开(公告)号：US20170216293A1

公开(公告)日：2017-08-03

申请号：US15492306

申请日：2017-04-20

申请人： LES LABORATOIRES SERVIER , VERNALIS (R&D) LTD

发明人： András KOTSCHY , Zoltán SZLÁVIK , Márton CSÉKEI , Attila PACZAL , Zoltán SZABÓ , Szabolcs SIPOS , Gábor RADICS , Ágnes PROSZENYÁK , Balázs BÁLINT , Alain BRUNO , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Frarnçoise PERRON-SIERRA

IPC分类号： A61K31/519 , A61K45/06 , A61K31/5377

CPC分类号： A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/55 , A61K45/06 , A61N5/10 , C07D495/04

摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R12, X, A and n are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.