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1.发明公开公开(公告)号：US20240245699A1
公开(公告)日：2024-07-25
申请号：US18591522
申请日：2024-02-29
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K9/20 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
CPC分类号： A61K31/5383 , A61K9/2059 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D401/10 , C07D401/14 , C07D405/14 , C07D471/04 , C07D491/10 , C07D491/107 , C07D498/04 , C07D498/14
摘要： Compounds of formula (I):
wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description.
Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.-
2.发明申请公开(公告)号：US20180258098A1
公开(公告)日：2018-09-13
申请号：US15738186
申请日：2016-06-22
发明人： Balazs BALINT , Márton CSÉKEI , Zoltán SZABÓ , Zoltan SZLAVIK , András KOTSCHY , Maia CHANRION , Olivier GENESTE , I-Jen CHEN , James Edward Paul DAVIDSON , James Brooke MURRAY , Szabolcs SIPOS , Levente ONDI , Ágnes PROSZENYÁK
IPC分类号： C07D495/04 , C07D491/048 , C07D487/04 , C07D471/04 , C07D409/12 , C07D405/12 , C07D405/04 , C07D403/12 , C07D333/56 , C07D307/81 , C07D307/80 , C07D209/12 , A61P35/02
CPC分类号： C07D495/04 , A61K45/06 , A61K2300/00 , A61P35/02 , C07D209/12 , C07D307/80 , C07D307/81 , C07D333/56 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D491/04 , C07D491/048
摘要： Compounds of formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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公开(公告)号：US20210355106A1
公开(公告)日：2021-11-18
申请号：US17282898
申请日：2019-10-18
发明人： Csaba WÉBER , András KOTSCHY , Attila VASAS , Árpád KISS , Balázs MOLNÁR , Andrea FIUMANA , Alba MACIAS , James Brooke MURRAY , Didier DEMARLES , Lisa IVANSCHITZ , Olivier GENESTE , Kristóf HEGEDÜS , Péter SPRÁNITZ , Tibor SOÓS
IPC分类号： C07D401/14 , A61P35/00 , A61K45/06 , A61K31/513 , C07D417/14 , A61K31/517 , C07D409/14 , C07D405/14
摘要： wherein R1, R2, R3, R4, R5, n and Q are as defined in the description.
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公开(公告)号：US20190144449A1
公开(公告)日：2019-05-16
申请号：US16306941
申请日：2017-06-09
发明人： András KOTSCHY , Csaba WÉBER , Attila VASAS , Balázs MOLNÁR , Árpád KISS , Alba MACIAS , James Brooke MURRAY , Elodie LEWKOWICZ , Olivier GENESTE , Maïa CHANRION , Didier DEMARLES , Lisa IVANSCHITZ
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D495/04 , A61K31/519 , A61K31/522
摘要： Compounds of formula (I): wherein R1, R2, J, K, L, n and W are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
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5.发明申请公开(公告)号：US20190144448A1
公开(公告)日：2019-05-16
申请号：US16306933
申请日：2017-06-09
发明人： András KOTSCHY , Csaba WÉBER , Attila VASAS , Balázs MOLNÁR , Árpád KISS , Alba MACIAS , James Brooke MURRAY , Elodie LEWKOWICZ , Olivier GENESTE , Maïa CHANRION , Didier DEMARLES
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , A61P37/02
摘要： Compounds of formula (I): wherein R1, R2, R3, n and W are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic and/or anti-proliferative agents.
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6.发明申请公开(公告)号：US20210290631A1
公开(公告)日：2021-09-23
申请号：US17341751
申请日：2021-06-08
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , Imre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , A61K45/06 , A61K31/4725 , A61K31/5377 , A61K9/20 , C07D401/14 , C07D405/14 , C07D401/10 , C07D471/04 , C07D491/10 , C07D498/04 , A61K31/496 , A61K31/506 , C07D491/107 , C07D498/14
摘要： wherein A1, A2, R3, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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7.发明申请公开(公告)号：US20200261464A1
公开(公告)日：2020-08-20
申请号：US16865855
申请日：2020-05-04
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , lmre FEJES , János TATAI , Miklós NYERGES , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Didier DURAND
IPC分类号： A61K31/5383 , C07D498/14 , C07D491/107 , A61K31/506 , A61K31/496 , C07D498/04 , C07D491/10 , C07D471/04 , C07D401/10 , C07D405/14 , C07D401/14 , A61K9/20 , A61K31/5377 , A61K31/4725 , A61K45/06
摘要： Compounds of formula (1): wherein A1, A2, Ra, Rb, Rc, Rd, R3, R4, R5 and T are as defined in the description. Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
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8.发明申请公开(公告)号：US20180170947A1
公开(公告)日：2018-06-21
申请号：US15737479
申请日：2016-06-22
发明人： Zoltan SZLAVIK , András KOTSCHY , Maïa CHANRION , Didier DEMARLES , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , Szabolcs SIPOS , Attila PACZAL , Balazs BALINT
IPC分类号： C07D495/04 , A61K45/06 , A61K31/519 , A61P35/00
CPC分类号： C07D495/04 , A61K31/519 , A61K45/06 , A61P35/00
摘要： Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R13, Ra, Rb, A and n are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.
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9.发明申请PHOSPHATE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权磷酸盐化合物，其制备方法和含有它们的药物组合物公开(公告)号：US20150313923A1
公开(公告)日：2015-11-05
申请号：US14800871
申请日：2015-07-16
发明人： Arnaud LE TIRAN , Thierry LE DIGUARHER , Jérôme-Benoît STARCK , Jean-Michel HENLIN , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL , Olivier GENESTE , James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN
IPC分类号： A61K31/675 , A61N5/10 , A61K45/06
CPC分类号： A61K31/675 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07F9/09 , C07F9/65583 , C07F9/6561
摘要： Compounds of formula (I): wherein X, Y, A1, A2, Ra, Rb, Rc, Rd, R3, R4, T and R5 are as defined in the description.Medicinal products containing the same which are useful in treating pathologies involving a deficit in apoptosis, such as cancer, auto-immune diseases, and diseases of the immune system.
摘要翻译： 式（I）化合物：其中X，Y，A1，A2，Ra，Rb，Rc，Rd，R3，R4，T和R5如说明书中所定义。 含有该物质的药物可用于治疗涉及细胞凋亡缺陷的病症，如癌症，自身免疫疾病和免疫系统疾病。
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10.发明申请公开(公告)号：US20200262816A1
公开(公告)日：2020-08-20
申请号：US16865799
申请日：2020-05-04
发明人： James Edward Paul DAVIDSON , James Brooke MURRAY , I-Jen CHEN , Claire WALMSLEY , Mark DODSWORTH , Johannes W.G. MEISSNER , Paul BROUGH , lmre FEJES , János TATAI , Miklós NYERGES , András KOTSCHY , Zoltán SZLÁVIK , Olivier GENESTE , Arnaud LE TIRAN , Thierry LE DIGUARHER , Jean-Michel HENLIN , Jérôme-Benoît STARCK , Anne-Françoise GUILLOUZIC , Guillaume DE NANTEUIL
IPC分类号： C07D401/14 , C07F9/6561 , C07D417/14 , A61N5/10 , A61K45/06 , A61K31/675 , A61K31/5377 , A61K31/497 , A61K31/496 , C07D471/04 , C07D409/14 , A61K31/4725 , C07D405/14
摘要： Compound of formula (I): wherein Het, R3, R4, R5, R7, R8, R9, t, p, p′, q, and q′ are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring pro-apoptotic agent.
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