公开(公告)号：US20180258098A1

公开(公告)日：2018-09-13

申请号：US15738186

申请日：2016-06-22

Applicant: LES LABORATOIRES SERVIER ,  VERNALIS (R&D) LTD

Inventor： Balazs BALINT ,  Márton CSÉKEI ,  Zoltán SZABÓ ,  Zoltan SZLAVIK ,  András KOTSCHY ,  Maia CHANRION ,  Olivier GENESTE ,  I-Jen CHEN ,  James Edward Paul DAVIDSON ,  James Brooke MURRAY ,  Szabolcs SIPOS ,  Levente ONDI ,  Ágnes PROSZENYÁK

IPC: C07D495/04 ,  C07D491/048 ,  C07D487/04 ,  C07D471/04 ,  C07D409/12 ,  C07D405/12 ,  C07D405/04 ,  C07D403/12 ,  C07D333/56 ,  C07D307/81 ,  C07D307/80 ,  C07D209/12 ,  A61P35/02

CPC classification number: C07D495/04 ,  A61K45/06 ,  A61K2300/00 ,  A61P35/02 ,  C07D209/12 ,  C07D307/80 ,  C07D307/81 ,  C07D333/56 ,  C07D403/12 ,  C07D405/04 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/04 ,  C07D491/048

Abstract: Compounds of formula (I); wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description.Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.

公开(公告)号：US20190031675A1

公开(公告)日：2019-01-31

申请号：US15737783

申请日：2016-06-22

Applicant: LES LABORATOIRES SERVIER ,  Vernalis (R&D) LTD.

Inventor： Zoltan SZLAVIK ,  Zoltán SZABÓ ,  Márton CSÉKEI ,  Attila PACZAL ,  András KOTSCHY ,  Alain BRUNO ,  Olivier GENESTE ,  I-Jen CHEN ,  James Edward Paul DAVIDSON ,  James Brooke MURRAY ,  Levente ONDI ,  Gábor RADICS ,  Szabolcs SIPOS ,  Ágnes PROSZENYÁK ,  Françoise PERRON-SIERRA ,  Balázs BÁLINT

IPC: C07D495/04 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07D495/04 ,  A61P35/00 ,  A61P37/00

Abstract: Compounds of formula (I): wherein R1, R2, R5, R6, R7, R12, X, Y, A, E and n are as defined in the description.Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.