公开(公告)号：US07413707B2

公开(公告)日：2008-08-19

申请号：US11430741

申请日：2006-05-09

Applicant: Kwang-wook Oh ,  Yu-jin Seo

Inventor： Kwang-wook Oh ,  Yu-jin Seo

IPC: B01D59/44

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/043 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N2035/00158

Abstract: Provided is a microchip assembly including a base holder, a microchip installed on the base holder and having at least one input hole into which a reaction sample is input and at least one microchamber accommodating the input reaction sample, a flipper rotatably installed at the outside of the microchip on the base holder and opening and closing the input hole of the microchip while flipping up in a vertically erected state or flipping down in a horizontal state, and slider installed at the outside of the flipper on the base holder to be capable of sliding and supporting the flipper in the erected state and flipping down the flipper while moving inside.

Abstract translation: 提供了一种微芯片组件，其包括基座，安装在基座上的微芯片，并具有输入反应样品的至少一个输入孔和容纳该输入反应样品的至少一个微室， 该微型芯片位于基座上，并且在垂直竖立状态下翻转或以水平状态翻转时打开和关闭微芯片的输入孔，以及滑块安装在底架上的导板外侧以能够滑动 并且在竖立状态下支撑导板，并在向内移动的情况下翻转导板。

公开(公告)号：US20060246487A1

公开(公告)日：2006-11-02

申请号：US11391850

申请日：2006-03-29

Applicant: Kwang-wook Oh ,  Yu-jin Seo

Inventor： Kwang-wook Oh ,  Yu-jin Seo

IPC: C12Q1/68

CPC classification number: B01L3/502715 ,  B01L3/565 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

Abstract: Provided is an apparatus for performing a chemical reaction using a microchip having at least one micro-channel. The device, which is a semiautomatic operating device for a microchip on which at least one micro-channel with a reagent inlet is formed, includes: a base which accommodates the microchip; a slider with injection inlets corresponding to the reagent inlets that reciprocally move parallel to the base; and a slider moving unit which selectively moves the slider to a first location at which the microchip is opened, after the injection inlet of the slider and the reagent inlet are aligned, and to a second location where the microchip is sealed by a bottom surface of the slider covering the reagent inlet.

Abstract translation: 提供一种使用具有至少一个微通道的微芯片进行化学反应的装置。 该装置是其上形成有至少一个具有试剂入口的微通道的微芯片的半自动操作装置，包括：容纳微芯片的基座; 具有与所述试剂入口相对应的注射入口的滑块，所述试剂入口与所述底座平行地往复移动; 以及滑块移动单元，其在滑块和试剂入口的注入口对齐之后，将滑块选择性地移动到微芯片打开的第一位置，并且在第二位置，微芯片被底部表面密封 滑块覆盖试剂入口。

公开(公告)号：US20060078931A1

公开(公告)日：2006-04-13

申请号：US11245348

申请日：2005-10-06

Applicant: Kwang-wook Oh ,  Yu-jin Seo ,  Gyeong-sik Ok ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

Inventor： Kwang-wook Oh ,  Yu-jin Seo ,  Gyeong-sik Ok ,  Jin-tae Kim ,  Kak Namkoong ,  Chin-sung Park

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: B01L3/502715 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

Abstract: Provided is a microchip unit, including a microchip on which a plurality of micro-channels are formed, a housing disposed below the microchip to fix the microchip; and at least two injecting and sealing elements having through-holes corresponding to inlets of the microchip. The injecting and sealing elements are vertically fixed on the top of the housing and slide in a horizontal direction from a first location to a second location and vice versa. The through-holes are aligned with inlets of the microchip so that a reaction solution can be injected through the through-holes when the injecting and sealing elements are placed at the first location. The inlets of the microchip are sealed by elastic members formed on bottom surfaces of the injecting and sealing elements when the injecting and sealing elements are placed at the second location.

Abstract translation: 提供一种微芯片单元，其包括形成有多个微通道的微芯片，设置在微芯片下面以固定微芯片的壳体; 以及至少两个具有对应于微芯片的入口的通孔的注入和密封元件。 注射和密封元件垂直地固定在壳体的顶部上，并且在从第一位置到第二位置的水平方向上滑动，反之亦然。 通孔与微芯片的入口对准，使得当注射和密封元件放置在第一位置时，反应溶液可以通过通孔注入。 当注射和密封元件放置在第二位置时，微芯片的入口由形成在注射和密封元件的底表面上的弹性构件密封。

公开(公告)号：US07892490B2

公开(公告)日：2011-02-22

申请号：US11391850

申请日：2006-03-29

Applicant: Kwang-wook Oh ,  Yu-jin Seo

Inventor： Kwang-wook Oh ,  Yu-jin Seo

IPC: G01N21/00 ,  G01N31/00 ,  C12M1/36 ,  C12M1/38

CPC classification number: B01L3/502715 ,  B01L3/565 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/0816 ,  B01L2400/065

Abstract: Provided is an apparatus for performing a chemical reaction using a microchip having at least one micro-channel. The device, which is a semiautomatic operating device for a microchip on which at least one micro-channel with a reagent inlet is formed, includes: a base which accommodates the microchip; a slider with injection inlets corresponding to the reagent inlets that reciprocally move parallel to the base; and a slider moving unit which selectively moves the slider to a first location at which the microchip is opened, after the injection inlet of the slider and the reagent inlet are aligned, and to a second location where the microchip is sealed by a bottom surface of the slider covering the reagent inlet.

Abstract translation: 提供一种使用具有至少一个微通道的微芯片进行化学反应的装置。 该装置是其上形成有至少一个具有试剂入口的微通道的微芯片的半自动操作装置，包括：容纳微芯片的基座; 具有与所述试剂入口相对应的注射入口的滑块，所述试剂入口与所述底座平行地往复移动; 以及滑块移动单元，其在滑块和试剂入口的注入口对齐之后，将滑块选择性地移动到微芯片打开的第一位置，并且在第二位置，微芯片被底部表面密封 滑块覆盖试剂入口。

公开(公告)号：US20060286582A1

公开(公告)日：2006-12-21

申请号：US11430741

申请日：2006-05-09

Applicant: Kwang-wook Oh ,  Yu-jin Seo

Inventor： Kwang-wook Oh ,  Yu-jin Seo

IPC: C12Q1/68

CPC classification number: B01L3/502715 ,  B01L3/502707 ,  B01L7/52 ,  B01L9/527 ,  B01L2200/027 ,  B01L2300/043 ,  B01L2300/0816 ,  B01L2400/0406 ,  G01N2035/00158

Abstract: Provided is a microchip assembly including a base holder, a microchip installed on the base holder and having at least one input hole into which a reaction sample is input and at least one microchamber accommodating the input reaction sample, a flipper rotatably installed at the outside of the microchip on the base holder and opening and closing the input hole of the microchip while flipping up in a vertically erected state or flipping down in a horizontal state, and slider installed at the outside of the flipper on the base holder to be capable of sliding and supporting the flipper in the erected state and flipping down the flipper while moving inside.

Abstract translation: 提供了一种微芯片组件，其包括基座，安装在基座上的微芯片，并具有输入反应样品的至少一个输入孔和容纳该输入反应样品的至少一个微室， 该微型芯片位于基座上，并且在垂直竖立状态下翻转或以水平状态翻转时打开和关闭微芯片的输入孔，以及滑块安装在底架上的导板外侧以能够滑动 并且在竖立状态下支撑导板，并在向内移动的情况下翻转导板。

公开(公告)号：US20060246580A1

公开(公告)日：2006-11-02

申请号：US11377793

申请日：2006-03-16

Applicant: Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chi-sung Park ,  Yu-jin Seo

Inventor： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chi-sung Park ,  Yu-jin Seo

IPC: C12M1/34

CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686

Abstract: Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.

Abstract translation: 提供了聚合酶链反应（PCR）模块和包括其的PCR系统。 所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离， 分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

公开(公告)号：US07754452B2

公开(公告)日：2010-07-13

申请号：US11377793

申请日：2006-03-16

Applicant: Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

Inventor： Jin-tae Kim ,  Kak Namkoong ,  Kwang-wook Oh ,  Chin-sung Park ,  Yu-jin Seo

IPC: C12P19/34 ,  C12M1/36 ,  G01N15/06

CPC classification number: B01L7/52 ,  B01L3/5027 ,  B01L9/52 ,  B01L2300/0822 ,  B01L2300/1827 ,  B01L2300/1844 ,  C12Q1/686

Abstract: Provided are a polymerase chain reaction (PCR) module and a PCR system including the same. The PCR module includes: a detachable PCR chip including a PCR chamber unit in which a PCR solution is accommodated; a heater unit for heating the PCR solution in the PCR chip with a preset temperature; a detecting unit for detecting a PCR signal of the PCR solution; a PCR chip installation unit for mounting/detaching the PCR chip using a one-touch method, in which the heater unit is adhered to the PCR chip with a predetermined pressure when mounting the PCR chip and the heater unit is separated from the PCR chip when detaching the PCR chip; and a housing covering at least the heater unit and the detecting unit so that they are not exposed to the outside.

Abstract translation: 提供了聚合酶链反应（PCR）模块和包括其的PCR系统。 所述PCR模块包括：可拆卸PCR芯片，其包括其中容纳PCR溶液的PCR室单元; 用于以预设温度加热PCR芯片中的PCR溶液的加热器单元; 用于检测PCR溶液的PCR信号的检测单元; 用于使用一触式方法安装/分离PCR芯片的PCR芯片安装单元，其中当将PCR芯片和加热器单元安装在PCR芯片上时，将加热器单元以预定的压力粘附到PCR芯片上，与PCR芯片分离， 分离PCR芯片; 以及至少覆盖加热器单元和检测单元的壳体，使得它们不暴露于外部。

公开(公告)号：US08403292B2

公开(公告)日：2013-03-26

申请号：US13402271

申请日：2012-02-22

Applicant: Kwang-wook Oh ,  Kak Namkoong ,  Chin-sung Park

Inventor： Kwang-wook Oh ,  Kak Namkoong ,  Chin-sung Park

IPC: F16K31/00 ,  F16K31/18

CPC classification number: F15C5/00 ,  F16K99/0001 ,  F16K99/0032 ,  F16K99/0044 ,  F16K99/0046 ,  F16K2099/0084 ,  F16K2099/0086 ,  F16K2099/0092 ,  Y10T137/0391 ,  Y10T137/2191 ,  Y10T137/2196 ,  Y10T137/2224 ,  Y10T137/4643

Abstract: Provided is a microvalve having a magnetic wax plug which includes a micro fluidic structure having an inlet portion and an outlet portion, a magnetic wax plug provided at a predetermined 5 section where the inlet portion and the outlet portion meet, existing in a solid state, melted at a temperature higher than a predetermined temperature, and reversibly moving along a magnetic field, so as to control flux of a fluid through the micro fluidic structure, a heating portion provided corresponding to the section and heating the magnetic wax plug to be melted, and a magnetic field 10 application portion selectively applying a magnetic field to a position where the melted magnetic wax plug arrives.

Abstract translation: 本发明提供一种具有磁性蜡塞的微型阀，其包括具有入口部和出口部的微流体结构，以固态存在的入口部和出口部相遇的规定5部设置的磁性蜡塞， 在高于预定温度的温度下熔化，并且沿着磁场可逆地移动，以便控制通过微流体结构的流体的流量，对应于该部分设置的加热部分并加热要熔化的磁性蜡塞， 以及选择性地将磁场施加到熔融的磁性蜡塞到达的位置的磁场10施加部。

公开(公告)号：US07579151B2

公开(公告)日：2009-08-25

申请号：US11191221

申请日：2005-07-27

Applicant: Young-sun Lee ,  Jung-im Han ,  Hyo-yeon Lee ,  Kak Namkoong ,  Kwang-wook Oh

Inventor： Young-sun Lee ,  Jung-im Han ,  Hyo-yeon Lee ,  Kak Namkoong ,  Kwang-wook Oh

IPC: C12Q1/68 ,  C07H21/00

CPC classification number: C12N15/1006

Abstract: Provided is a method of isolating and purifying biomolecules using a hydrogel, the method including: bring a sample containing charged biomolecules into contact with a hydrogel to bind the biomolecules to the hydrogel; washing the hydrogel bound with the biomolecules; and eluting the bound biomolecules using an elution solvent. According to the method, the use of a hydrogel with a large surface area reduces the isolation time of biomolecules to 5 min or less, an external device such as an electromagnet is not required, and small-sized systems or LOC can be easily implemented due to applicability to microsystems through a polymer patterning technique.

Abstract translation: 提供了使用水凝胶分离和纯化生物分子的方法，该方法包括：使含有带电生物分子的样品与水凝胶接触以将生物分子结合至水凝胶; 洗涤与生物分子结合的水凝胶; 并使用洗脱溶剂洗脱结合的生物分子。 根据该方法，使用具有大表面积的水凝胶将生物分子的隔离时间减少到5分钟以下，不需要诸如电磁体的外部装置，并且可以容易地实现小尺寸系统或LOC 通过聚合物图案化技术适用于微系统。

公开(公告)号：US07424995B2

公开(公告)日：2008-09-16

申请号：US11327236

申请日：2006-01-05

Applicant: Kwang-wook Oh ,  Kak Namkoong

Inventor： Kwang-wook Oh ,  Kak Namkoong

IPC: F16K31/02

CPC classification number: F16K31/0679 ,  Y10T137/87788

Abstract: A valve is provided. The valve includes a plunger, a chamber having a first region and a second region where the plunger moves back and forth, a first electromagnet and a second electromagnet which are located around the first region and the second region to apply a magnetic field to the plunger, a fluid inlet through which a fluid enters into the chamber, located between the first region and the second region of the chamber, and a second fluid outlet located on a vertical end part of the second region away from the first region.

Abstract translation: 提供阀门。 阀包括柱塞，具有第一区域和柱塞前后移动的第二区域的腔室，位于第一区域和第二区域周围的第一电磁体和第二电磁体，以向柱塞施加磁场 ，流体入口，流体通过所述流体入口位于所述室的所述第一区域和所述第二区域之间，以及位于所述第二区域的远离所述第一区域的垂直端部的第二流体出口。