Ultrasound based tracking system using triangulation and spatial positioning with detachable reference frame and ultrasound emitters

    公开(公告)号:US11633171B2

    公开(公告)日:2023-04-25

    申请号:US17860314

    申请日:2022-07-08

    摘要: The present invention relates to an ultrasound-based system for localizing a medical device within the field of view of an ultrasound imaging probe. A localization system is provided that includes at least three ultrasound emitters that are arranged on a frame; and a position triangulation unit. The frame is adapted for attachment to an ultrasound imaging probe. The position triangulation unit determines a spatial position of the ultrasound detector relative to the at least three ultrasound emitters based on signals received from an ultrasound detector that is attached to the medical device. The frame includes a detachable reference volume comprising a background volume and an inclusion or void. When the detachable reference volume is attached to the frame and the frame is attached to the ultrasound imaging probe the inclusion or void provides a corresponding image feature within the field of view of the ultrasound imaging probe for use in calibrating the field of view of the ultrasound imaging probe with the coordinate system of the localization system.

    Ultrasound based tracking
    4.
    发明授权

    公开(公告)号:US11413011B2

    公开(公告)日:2022-08-16

    申请号:US16063858

    申请日:2016-12-13

    摘要: The present invention relates to an ultrasound-based system for localizing a medical device within the field of view of an ultrasound imaging probe. A localization system is provided that includes at least three ultrasound emitters that are arranged on a frame; and a position triangulation unit. The frame is adapted for attachment to an ultrasound imaging probe. The position triangulation unit determines a spatial position of the ultrasound detector relative to the at least three ultrasound emitters based on signals received from an ultrasound detector that is attached to the medical device. The frame includes a detachable reference volume comprising a background volume and an inclusion or void. When the detachable reference volume is attached to the frame and the frame is attached to the ultrasound imaging probe the inclusion or void provides a corresponding image feature within the field of view of the ultrasound imaging probe for use in calibrating the field of view of the ultrasound imaging probe with the coordinate system of the localization system.

    Synchronized tracking of multiple interventional medical devices

    公开(公告)号:US11497563B2

    公开(公告)日:2022-11-15

    申请号:US17059811

    申请日:2019-06-06

    IPC分类号: A61B34/20 A61B8/08 A61B8/00

    摘要: A controller (240/340) for simultaneously tracking multiple interventional medical devices includes a memory (242/342) that stores instructions and a processor (241/341) that executes the instructions. When executed by the processor (241/341), the instructions cause the controller to execute a process that includes receiving timing information from a first signal emitted from an ultrasound probe (252/352) and reflective of timing when the ultrasound probe (252/352) transmits ultrasound beams to generate ultrasound imagery. The process executed by the controller also includes forwarding the timing information to be available for use by a first acquisition electronic component (232/332). The first acquisition electronic component (232/332) also receives sensor information from a first passive ultrasound sensor (S1) on a first interventional medical device (212/312). The timing information is used to synchronize the sensor information from the first passive ultrasound sensor (S1) on the first interventional medical device (212/312) with sensor information from a second passive ultrasound sensor (S2) on a second interventional medical device (216/316).

    Tracking a feature of an interventional device

    公开(公告)号:US11369340B2

    公开(公告)日:2022-06-28

    申请号:US16337230

    申请日:2017-09-29

    摘要: The present invention relates to a system for indicating a position of an interventional device feature (11a) of an interventional device (11) respective an image plane (12) defined by an ultrasound imaging probe (18) of a beamforming ultrasound imaging system (15) in which the position of the interventional device feature (11a) is determined based on ultrasound signals transmitted between the ultrasound imaging probe (18) and an ultrasound transducer (16) attached to the interventional device at a predetermined distance (Lp) from the interventional device feature (11a). An icon providing unit (IPU) provides a first icon (Cde) indicative of a circular zone with a radius corresponding to the predetermined distance (Lp). The first icon (Cde) is displayed in a fused image that includes a reconstructed ultrasound image (RUI) from the beamforming ultrasound imaging system.

    Interventional device recognition

    公开(公告)号:US11275150B2

    公开(公告)日:2022-03-15

    申请号:US15778715

    申请日:2016-12-02

    摘要: The present invention relates to an apparatus (10) for tracking a position of an interventional device (11) respective an image plane (12) of an ultrasound field. The position includes an out-of-plane distance (Dop). A geometry-providing unit (GPU) includes a plurality of transducer-to-distal-end lengths (Ltde1 . . . n), each length corresponding to a predetermined distance (Ltde) between a distal end (17, 47) of an interventional device (11, 41) and an ultrasound detector (16, 46) attached to the interventional device, for each of a plurality of interventional device types (T1 . . . N). An image fusion unit (IFU) receives data indicative of the type (T) of the interventional device being tracked; and based on the type (T): selects from the geometry-providing unit (GPU), a corresponding transducer-to-distal-end length (Ltde); and indicates in a reconstructed ultrasound image (RUI) both the out-of-plane distance (Dop) and the transducer-to-distal-end length (Ltde) for the interventional device within the ultrasound field.

    Detecting target molecules in a sample
    9.
    发明授权

    公开(公告)号:US10670589B2

    公开(公告)日:2020-06-02

    申请号:US15710887

    申请日:2017-09-21

    摘要: The invention relates to detection the presence of a target molecule in a sample, wherein the sample is contacted with a substrate, the substrate subsequently being washed in a wash step. In particular, the invention relates to a method of detecting the presence of a target molecule in a sample, the method comprising: (a) contacting the sample (37) with a substrate having immobilized thereon probe molecules that specifically binds to the target molecule; (b) washing the substrate (38) in a wash step by a wash fluid in order to remove or dilute unbound target molecules; (c) detect the presence of resultant binding complexes (39) on the substrate to determine whether the target molecule is present in the sample—The wash fluid being substantially refractive index matched to the substrate.