知搜-全球专利检索

  1. 登录
  2. 注册

搜索结果

46 条记录 (耗时 0.027 秒)

    Treatment methods using Dkk-1 antibodies
    2.
    发明授权
    Treatment methods using Dkk-1 antibodies 有权
    使用Dkk-1抗体的治疗方法

    公开(公告)号：US08101184B2

    公开(公告)日：2012-01-24

    申请号：US12603303

    申请日：2009-10-21

    申请人： Ji Li ,  Wenyan Shen ,  Hsieng Sen Lu ,  William Gleason Richards

    发明人： Ji Li ,  Wenyan Shen ,  Hsieng Sen Lu ,  William Gleason Richards

    IPC分类号： A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

    摘要翻译： 本发明提供了特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。

    Antibodies to Dkk-1
    3.
    发明授权
    Antibodies to Dkk-1 有权
    Dkk-1抗体

    公开(公告)号：US07709611B2

    公开(公告)日：2010-05-04

    申请号：US11197665

    申请日：2005-08-04

    申请人： Ji Li ,  Wenyan Shen ,  Hsieng Sen Lu ,  William Gleason Richards

    发明人： Ji Li ,  Wenyan Shen ,  Hsieng Sen Lu ,  William Gleason Richards

    IPC分类号： C07K16/00 ,  C07K16/32 ,  A61K39/00 ,  A61K39/395

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

    摘要翻译： 本发明提供了特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。

    Antibodies to Dkk-1
    4.
    发明申请
    Antibodies to Dkk-1 有权
    Dkk-1抗体

    公开(公告)号：US20060127393A1

    公开(公告)日：2006-06-15

    申请号：US11197665

    申请日：2005-08-04

    申请人： Ji Li ,  Wenyan Shen ,  Hsieng Lu ,  William Richards

    发明人： Ji Li ,  Wenyan Shen ,  Hsieng Lu ,  William Richards

    IPC分类号： A61K39/395 ,  C07H21/04 ,  C12P21/06 ,  C07K16/28 ,  C07K16/44 ,  C12N5/06

    CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

    摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.

    摘要翻译： 本发明提供了特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。

    Ozone contact tank and ozone contact method
    6.
    发明授权
    Ozone contact tank and ozone contact method 有权

    公开(公告)号：US09764970B2

    公开(公告)日：2017-09-19

    申请号：US13807751

    申请日：2011-01-28

    申请人： Ji Li ,  Wenyi Dong

    发明人： Ji Li ,  Wenyi Dong

    IPC分类号： B01F3/04 ,  B01F5/06 ,  C02F1/78

    CPC分类号： C02F1/78 ,  B01F3/04106 ,  B01F3/04524 ,  B01F5/0688 ,  B01F2003/04886 ,  C02F2201/78 ,  C02F2301/022 ,  C02F2303/04 ,  C02F2303/18

    摘要： The disclosure provides an ozone contact tank, which includes a water inlet gallery (1), an aeration gallery (2), a water distribution zone (3), a reaction zone (4) and a water outlet trough (5) which are disposed according to the intake order and are communicated in sequence; the top of the water inlet gallery (1) is communicated with the top of the aeration gallery (2); the bottom of the aeration gallery (2) is communicated with a water inlet end of the water distribution zone (3) via a narrow passage (6); the top of the water distribution zone (3) is communicated with the bottom of the reaction zone (4) via a perforated plate (41); the top of the reaction zone (4) is communicated with the water outlet trough (5). The disclosure also provides an ozone contact method using the ozone contact tank, which can greatly improve the disinfection effect.

    Integrated multi-datastream transmission technology
    8.
    发明授权
    Integrated multi-datastream transmission technology 有权
    集成多数据流传输技术

    公开(公告)号：US09054839B2

    公开(公告)日：2015-06-09

    申请号：US13576198

    申请日：2010-12-31

    申请人： Hua Chao ,  Ji Li ,  Yonggang Wang ,  Zhongji Hu

    发明人： Hua Chao ,  Ji Li ,  Yonggang Wang ,  Zhongji Hu

    IPC分类号： H04L27/28 ,  H04W4/00 ,  H04H20/71 ,  H04L5/00 ,  H04L27/34

    CPC分类号： H04L5/0044 ,  H04L5/0091 ,  H04L27/3488

    摘要： The present invention is related to integrated multi-datastream transmission technology, more particularly, to integrated multi-datastream modulation technology. According to one aspect of the present invention, there is provided a modulation equipment (10), including: a symbol integration means (101), configured to combine a first bit stream with a second bit stream to form a symbol to be modulated; a symbol mapping means (102), configured to map the symbol to be modulated into a QAM modulation symbol according to a set of predetermined mapping rules; wherein, in the set of predetermined mapping rules, multiple constellations corresponding to any first bit stream are located in at least two quadrants in the constellation diagram, while multiple constellations corresponding to any second bit stream are located in at least two quadrants in the constellation diagram. The integrated transmission of a first service data and a second service data (e.g., unicast service data and MBMS data) may be supported and has a better performance than the prior art especially in single cell scenario by using the method, equipment and device in the present invention.

    摘要翻译： 本发明涉及集成多数据流传输技术，更具体地涉及集成多数据流调制技术。 根据本发明的一个方面，提供了一种调制设备（10），包括：符号集成装置（101），被配置为将第一比特流与第二比特流组合以形成要调制的符号; 符号映射装置（102），被配置为根据一组预定映射规则将要调制的符号映射到QAM调制符号中; 其中，在所述预定映射规则集合中，对应于任何第一比特流的多个星座位于星座图中的至少两个象限中，而对应于任何第二比特流的多个星座位于星座图中的至少两个象限中 。 可以支持第一服务数据和第二服务数据（例如，单播服务数据和MBMS数据）的集成传输，并且具有比现有技术更好的性能，特别是在单小区场景中，通过使用方法，设备和设备在 本发明。

    INTEGRATED MULTI-DATASTREAM TRANSMISSION TECHNOLOGY
    9.
    发明申请
    INTEGRATED MULTI-DATASTREAM TRANSMISSION TECHNOLOGY 有权
    综合多数据传输技术

    公开(公告)号：US20120300691A1

    公开(公告)日：2012-11-29

    申请号：US13576198

    申请日：2010-12-31

    申请人： Hua Chao ,  Ji Li ,  Yonggang Wang ,  Zhongji Hu

    发明人： Hua Chao ,  Ji Li ,  Yonggang Wang ,  Zhongji Hu

    IPC分类号： H04L27/36 ,  H04H20/71 ,  H04L27/20 ,  H04W72/04

    CPC分类号： H04L5/0044 ,  H04L5/0091 ,  H04L27/3488

    摘要： The present invention is related to integrated multi-datastream transmission technology, more particularly, to integrated multi-datastream modulation technology. According to one aspect of the present invention, there is provided a modulation equipment (10), including: a symbol integration means (101), configured to combine a first bit stream with a second bit stream to form a symbol to be modulated; a symbol mapping means (102), configured to map the symbol to be modulated into a QAM modulation symbol according to a set of predetermined mapping rules; wherein, in the set of predetermined mapping rules, multiple constellations corresponding to any first bit stream are located in at least two quadrants in the constellation diagram, while multiple constellations corresponding to any second bit stream are located in at least two quadrants in the constellation diagram. The integrated transmission of a first service data and a second service data (e.g., unicast service data and MBMS data) may be supported and has a better performance than the prior art especially in single cell scenario by using the method, equipment and device in the present invention.

    摘要翻译： 本发明涉及集成多数据流传输技术，更具体地涉及集成多数据流调制技术。 根据本发明的一个方面，提供了一种调制设备（10），包括：符号集成装置（101），被配置为将第一比特流与第二比特流组合以形成要调制的符号; 符号映射装置（102），被配置为根据一组预定映射规则将要调制的符号映射到QAM调制符号中; 其中，在所述预定映射规则集合中，对应于任何第一比特流的多个星座位于星座图中的至少两个象限中，而对应于任何第二比特流的多个星座位于星座图中的至少两个象限中 。 可以支持第一服务数据和第二服务数据（例如，单播服务数据和MBMS数据）的集成传输，并且具有比现有技术更好的性能，特别是在单小区场景中，通过使用方法，设备和设备在 本发明。

    Resonance converting apparatus and synchronous rectification circuit
    10.
    发明授权
    Resonance converting apparatus and synchronous rectification circuit 有权
    共振转换装置和同步整流电路

    公开(公告)号：US08243475B2

    公开(公告)日：2012-08-14

    申请号：US12603620

    申请日：2009-10-22

    申请人： LiuChun Zhou ,  Zhong Zeng ,  Xin Guo ,  Ji Li ,  ZhiHong Ye

    发明人： LiuChun Zhou ,  Zhong Zeng ,  Xin Guo ,  Ji Li ,  ZhiHong Ye

    IPC分类号： H02M3/335

    CPC分类号： H02M3/33592 ,  H02M2001/0058 ,  Y02B70/1433 ,  Y02B70/1475 ,  Y02B70/1491

    摘要： Provided is a resonance converting apparatus. The resonance converting apparatus preferably includes a resonant circuit, a bridge-type converter, and a synchronous rectification circuit. In which the resonant circuit has a transformer. The bridge-type converter connects with a primary side of the transformer, and operates open or close according to a switching signal. The synchronous rectification circuit further includes a pair of rectification transistors and driving circuits. The driving circuits correspondingly connect with channels to the rectification transistors, and respectively examine the current passing through the rectification transistors. A sensing signal is then generated. In accordance with the switching signal and the sensing signal, a driving signal is generated for driving the rectification transistor. Consequently the apparatus can raise the efficiency of the resonance converting apparatus.

    摘要翻译： 提供了一种谐振转换装置。 共振转换装置优选地包括谐振电路，桥式转换器和同步整流电路。 其中谐振电路具有变压器。 桥式转换器与变压器的初级侧相连，根据开关信号开启或关闭。 同步整流电路还包括一对整流晶体管和驱动电路。 驱动电路相应地将通道连接到整流晶体管，并分别检查通过整流晶体管的电流。 然后产生感测信号。 根据开关信号和感测信号，产生用于驱动整流晶体管的驱动信号。 因此，该装置可以提高谐振转换装置的效率。