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公开(公告)号：US08999343B2
公开(公告)日：2015-04-07
申请号：US13816894
申请日：2011-08-15
申请人： Huiquan Han , Taruna Arora , Qing Chen , Hsieng Sen Lu , Xiaolan Zhou
发明人： Huiquan Han , Taruna Arora , Qing Chen , Hsieng Sen Lu , Xiaolan Zhou
CPC分类号： C07K16/26 , A61K2039/505 , C07K16/22 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： Myostatin antagonists, including myostatin binding antibodies, are disclosed. Also disclosed are nucleic acids encoding and cells including myostatin antagonists; methods of production; and methods of use.
摘要翻译： 公开了肌生成抑制素拮抗剂，包括肌生长抑制素结合抗体。 还公开了编码核酸和包括肌肉生长抑制素拮抗剂的细胞; 生产方式; 和使用方法。
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公开(公告)号：US20120087912A1
公开(公告)日：2012-04-12
申请号：US13323566
申请日：2011-12-12
申请人： Ji Li , Wenyan Shen , Hsieng Sen Lu , William Gleason Richards
发明人： Ji Li , Wenyan Shen , Hsieng Sen Lu , William Gleason Richards
IPC分类号： A61K39/395 , C12N5/10 , C12N15/63 , C07K16/18 , A61P1/00 , A61P21/00 , A61P3/10 , C07H21/04 , A61P19/02 , A61P29/00 , A61P25/00 , A61P27/02 , A61P13/12 , A61P11/00 , A61P17/00 , A61P25/28 , A61P25/16 , C12P21/06
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
摘要翻译： 本发明提供了特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。
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公开(公告)号：US20100172895A1
公开(公告)日：2010-07-08
申请号：US12642711
申请日：2009-12-18
申请人： Thomas C. Boone , David W. Brankow , Colin V. Gegg, JR. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
发明人： Thomas C. Boone , David W. Brankow , Colin V. Gegg, JR. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
CPC分类号： C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
摘要翻译： 提供了结合人CGRP受体（CGRP R）的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。 抗原结合蛋白可以抑制CGRP R与CGRP的结合，并且可用于多种CGRP R相关疾病，包括治疗和/或预防偏头痛。
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公开(公告)号：US08101184B2
公开(公告)日：2012-01-24
申请号：US12603303
申请日：2009-10-21
申请人： Ji Li , Wenyan Shen , Hsieng Sen Lu , William Gleason Richards
发明人： Ji Li , Wenyan Shen , Hsieng Sen Lu , William Gleason Richards
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
摘要翻译： 本发明提供了特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。
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公开(公告)号：US07794970B2
公开(公告)日：2010-09-14
申请号：US11522577
申请日：2006-09-18
申请人： John O. Hui , Mitsuru Haniu , Hsieng Sen Lu
发明人： John O. Hui , Mitsuru Haniu , Hsieng Sen Lu
CPC分类号： C07K16/065 , A61K39/395 , C07K2317/54 , C12Q1/37 , Y10S424/809 , Y10S530/866
摘要： Methods for generating F(ab′)2 fragments from antibodies using thermolysin as well as F(ab′)2 fragments and compositions comprising F(ab′)2 fragments generated by the method are described.
摘要翻译： 描述了从使用嗜热菌蛋白的抗体以及F（ab'）2片段产生F（ab'）2片段的方法和包含由该方法生成的F（ab'）2片段的组合物的方法。
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公开(公告)号：US20100040619A1
公开(公告)日：2010-02-18
申请号：US12603303
申请日：2009-10-21
申请人： Ji LI , Wenyan SHEN , Hsieng Sen LU , William Gleason RICHARDS
发明人： Ji LI , Wenyan SHEN , Hsieng Sen LU , William Gleason RICHARDS
IPC分类号： A61K39/395 , A61P19/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind Dkk-1 polypeptides. The subject antibodies and fragments bind with high affinity to a conformational epitope located in the carboxy region of the Dkk-1 protein. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases including bone disorders, inflammatory diseases, neurological diseases, ocular diseases, renal diseases, pulmonary diseases and skin diseases are also disclosed.
摘要翻译： 本发明提供了特异性结合Dkk-1多肽的抗体及其免疫功能片段。 受试抗体和片段以高亲和力结合位于Dkk-1蛋白的羧基区域的构象表位。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病，包括骨骼疾病，炎性疾病，神经疾病，眼部疾病，肾脏疾病，肺部疾病和皮肤疾病。
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公开(公告)号：US5670342A
公开(公告)日：1997-09-23
申请号：US417640
申请日：1995-04-06
申请人： Josette Francoise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
发明人： Josette Francoise Carnahan , Shinichi Hara , Hsieng Sen Lu , John Philip Mayer , Steven Kiyoshi Yoshinaga
IPC分类号： C12N15/09 , A61K38/00 , A61P1/00 , A61P11/00 , A61P25/00 , A61P43/00 , C07K14/47 , C07K14/475 , C12N1/19 , C12N1/21 , C12N5/10 , C12P21/02 , C12Q1/02 , C12R1/91 , C07K19/00 , A61K38/18 , C12N15/62
CPC分类号： C07K14/4756 , C07K14/4705 , A61K38/00
摘要： Novel peptides are described which are biologically active derivatives of the EGF-like domain of NDF/heregulins and which stimulate the proliferation and differentiation of colon epithelial cells and support the survival and growth of Schwann cells.
摘要翻译： 描述了新的肽，其是NDF /本土的EGF样结构域的生物活性衍生物，其刺激结肠上皮细胞的增殖和分化并支持施万细胞的存活和生长。
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公开(公告)号：US09102731B2
公开(公告)日：2015-08-11
申请号：US12642711
申请日：2009-12-18
申请人： Thomas C. Boone , David W. Brankow , Colin V. Gegg, Jr. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
发明人： Thomas C. Boone , David W. Brankow , Colin V. Gegg, Jr. , Shaw-Fen Sylvia Hu , Chadwick T. King , Hsieng Sen Lu , Licheng Shi , Cen Xu
CPC分类号： C07K16/2869 , A61K39/395 , A61K39/39533 , A61K2039/505 , C07K2317/21 , C07K2317/32 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/30
摘要： Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.
摘要翻译： 提供了结合人CGRP受体（CGRP R）的抗原结合蛋白。 还提供编码抗原结合蛋白，载体和编码抗原结合蛋白的核酸的核酸。 抗原结合蛋白可以抑制CGRP R与CGRP的结合，并且可用于多种CGRP R相关疾病，包括治疗和/或预防偏头痛。
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公开(公告)号：US20130209489A1
公开(公告)日：2013-08-15
申请号：US13816894
申请日：2011-08-15
申请人： Huiquan Han , Taruna Arora , Qing Chen , Hsieng Sen Lu , Xiaolan Zhou
发明人： Huiquan Han , Taruna Arora , Qing Chen , Hsieng Sen Lu , Xiaolan Zhou
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , A61K2039/505 , C07K16/22 , C07K2317/14 , C07K2317/34 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y02A50/466
摘要： There are disclosed selective myostatin antagonists (including antibodies), nucleic acids encoding them, and methods of making and using them. Neutralizing antibodies recognizing the conformational epitope near position 21 to 31 and position 50 to 60.
摘要翻译： 公开了选择性肌生成抑制素拮抗剂（包括抗体），编码它们的核酸，以及制备和使用它们的方法。 识别位置21至31位置50至60附近的构象表位的中和抗体。
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公开(公告)号：US20130209475A1
公开(公告)日：2013-08-15
申请号：US13878619
申请日：2011-10-27
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K39/3955 , A61K2039/505 , A61K2039/507 , C07K16/22 , C07K2317/21 , C07K2317/34 , C07K2317/76 , C07K2317/92
摘要： The present invention provides antibodies and immunologically functional fragments thereof that specifically bind DKK1 polypeptides. Methods for preparing such antibodies or fragments thereof as well as physiologically acceptable compositions containing the antibodies or fragments are also provided. Use of the antibodies and fragments to treat various diseases are also disclosed.
摘要翻译： 本发明提供了特异性结合DKK1多肽的抗体及其免疫功能片段。 还提供了制备此类抗体或其片段的方法以及含有抗体或片段的生理上可接受的组合物。 还公开了使用抗体和片段来治疗各种疾病。
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