公开(公告)号：US20140030315A1

公开(公告)日：2014-01-30

申请号：US13740913

申请日：2013-01-14

Applicant: Jed K. JOHNSON

Inventor： Jed K. JOHNSON

IPC: A61K9/70 ,  A61K47/32 ,  A61K35/12

CPC classification number: A61K9/70 ,  A61K35/12 ,  A61K47/32 ,  A61L27/3804 ,  A61L27/54 ,  A61L27/60 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/414

Abstract: A system for manufacturing an artificial construct suitable for transplantation into a biological organism that includes a two or three three-dimensional preform that is based on the actual two or three-dimensional structure of a native mammalian tissue; and an electrospinning apparatus, wherein the electrospinning apparatus is operative to deposit at least one layer of polymer fibers on the preform to form a polymer scaffold, and wherein the orientation of the fibers in the scaffold relative to one another is substantially parallel.

Abstract translation: 一种用于制造适于移植到生物体中的人造构造的系统，其包括基于天然哺乳动物组织的实际二维或三维结构的两个或三个三维预成型体; 和静电纺丝装置，其中所述静电纺丝装置可操作以将至少一层聚合物纤维沉积在所述预成型件上以形成聚合物支架，并且其中所述支架中纤维相对于彼此的取向基本上平行。

公开(公告)号：US20150086607A1

公开(公告)日：2015-03-26

申请号：US14496070

申请日：2014-09-25

Applicant: Jed K. JOHNSON ,  Ross KAYUHA

Inventor： Jed K. JOHNSON ,  Ross KAYUHA

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/58 ,  A61L27/20 ,  A61L27/26 ,  A61L27/50 ,  A61L27/38

CPC classification number: A61L27/18 ,  A61L27/14 ,  A61L27/20 ,  A61L27/26 ,  A61L27/38 ,  A61L27/3804 ,  A61L27/507 ,  A61L27/54 ,  A61L27/58 ,  A61L31/04 ,  A61L31/14 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/406 ,  A61L2300/41 ,  A61L2300/412 ,  A61L2300/414 ,  A61L2300/416 ,  A61L2300/64 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/20 ,  A61L2430/34 ,  Y10T428/249947

Abstract: A synthetic construct suitable for implantation into a biological organism that includes at least one polymer scaffold; wherein the at least one polymer scaffold includes at least one layer of polymer fibers that have been deposited by electrospinning; wherein the orientation of the fibers in the at least one polymer scaffold relative to one another is generally parallel, random, or both; and wherein the at least one polymer scaffold has been adapted to function as at least one of a substantially two-dimensional implantable structure and a substantially three-dimensional implantable tubular structure.

Abstract translation: 适于植入生物体的合成构造体，其包括至少一种聚合物支架; 其中所述至少一种聚合物支架包括通过静电纺丝沉积的至少一层聚合物纤维; 其中所述至少一个聚合物支架中的纤维相对于彼此的取向通常是平行的，随机的或两者的; 并且其中所述至少一种聚合物支架已适于用作基本上二维可植入结构和基本上三维可植入管状结构中的至少一种。

公开(公告)号：US20150132423A1

公开(公告)日：2015-05-14

申请号：US14570853

申请日：2014-12-15

Applicant: Jed K. JOHNSON

Inventor： Jed K. JOHNSON

IPC: B29C67/00 ,  A61F2/20

CPC classification number: B29C64/00 ,  A61F2/04 ,  A61F2/20 ,  A61F2002/043 ,  A61F2002/046 ,  A61F2240/005 ,  A61L27/3612 ,  A61L27/3882 ,  A61L27/40 ,  A61L2430/22 ,  B29K2067/003 ,  B29K2075/00 ,  B29K2311/00 ,  A61L27/18 ,  C08L77/12 ,  A61L29/06

Abstract: A system for manufacturing a synthetic organ suitable for transplantation into a biological organism is provided. This synthetic organ includes a three-dimensional polymer scaffold, wherein the shape and dimensions of the polymer scaffold are based on a native organ, wherein the polymer scaffold further includes at least one layer of polymer fibers that have been deposited by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both; and wherein the polymer scaffold has been preseeded with at least one type of biological cell prior to implantation into a biological organism, and wherein the at least one type of biological cell is operative to facilitate integration of the polymer scaffold into the organism so that the polymer scaffold may function in a manner significantly similar to or the same as the native organ.

Abstract translation: 提供了一种用于制造适合于移植到生物体内的合成器官的系统。 该合成器官包括三维聚合物支架，其中聚合物支架的形状和尺寸基于天然器官，其中聚合物支架还包括通过静电纺丝沉积的至少一层聚合物纤维，并且其中 支架中的纤维相对于彼此的取向通常是平行的，随机的或两者的; 并且其中所述聚合物支架在植入生物生物体之前已被预先用至少一种类型的生物细胞，并且其中所述至少一种类型的生物细胞可操作以促进所述聚合物支架整合到所述生物体中，使得所述聚合物 支架可以以与天然器官显着相似或相同的方式起作用。