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公开(公告)号：US20190135912A1
公开(公告)日：2019-05-09
申请号：US16184270
申请日：2018-11-08
Applicant: Janssen Biotech, Inc.
Inventor： Ellen Chi , Judith Connor , Chichi Huang , Jarrat Jordan , Xiefan Lin-Schmidt , Jinquan Luo , Lu Lu , Christian Martinez , Galina Obmolova , Ronald Swanson
IPC: C07K16/24
Abstract: Broadly neutralizing interferon-α and interferon-ω antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are usefule in the treatment of diseases associated with increased production of IFNα and IFNω.
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公开(公告)号：US20190106489A1
公开(公告)日：2019-04-11
申请号：US16222285
申请日：2018-12-17
Applicant: Janssen Biotech, Inc.
Inventor： Ellen Chi , Judith Connor , Chichi Huang , Jarrat Jordan , Xiefan Lin-Schmidt , Jinquan Luo , Lu Lu , Christian Martinez , Galina Obmolova , Ronald Swanson
CPC classification number: C07K16/249 , A61K38/13 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , A61K2300/00
Abstract: The present invention relates to antibodies that broady neutralize interferon-α and interferon-ω, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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公开(公告)号：US10155809B2
公开(公告)日：2018-12-18
申请号：US15707317
申请日：2017-09-18
Applicant: Janssen Biotech, Inc.
Inventor： Ellen Chi , Judith Connor , Chichi Huang , Jarrat Jordan , Xiefan Lin-Schmidt , Jinquan Luo , Lu Lu , Christian Martinez , Galina Obmolova , Ronald Swanson
Abstract: Broadly neutralizing interferon-α and interferon-ω antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFNα and IFNω.
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公开(公告)号：US20170327560A1
公开(公告)日：2017-11-16
申请号：US15586463
申请日：2017-05-04
Applicant: Janssen Biotech, Inc.
Inventor： Anthony Armstrong , Judith Ann Connor , Jennifer Furman , Chichi Huang , Michael J. Hunter , Xiefan Lin-Schmidt , Serena Nelson , Shamina Rangwala , Shannon Mullican , Jose Antonio Chavez
IPC: C07K14/765 , C07K14/475 , A61K38/00
CPC classification number: C07K14/765 , A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/1875 , A61K38/19 , C07K14/435 , C07K14/46 , C07K14/47 , C07K14/475 , C07K14/51 , C07K2319/31 , C12N5/12 , C12N15/00 , C12N15/09 , C12N15/11 , C12N15/62 , C12N15/63
Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.
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公开(公告)号：US10759854B2
公开(公告)日：2020-09-01
申请号：US16424907
申请日：2019-05-29
Applicant: Janssen Biotech, Inc.
Inventor： Ellen Chi , Judith Connor , Chichi Huang , Jarrat Jordan , Xiefan Lin-Schmidt , Jinquan Luo , Lu Lu , Christian Martinez , Galina Obmolova , Ronald Swanson
IPC: C07K16/24 , A61K38/13 , A61K45/06 , A61K39/395 , A61K39/00
Abstract: The present invention relates to antibodies that broady neutralize interferon-α and interferon-ω, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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Patent Agency Ranking
公开(公告)号：US10336812B2
公开(公告)日：2019-07-02
申请号：US15586463
申请日：2017-05-04
Applicant: Janssen Biotech, Inc.
Inventor： Anthony Armstrong , Judith Ann Connor , Jennifer Furman , Chichi Huang , Michael J. Hunter , Xiefan Lin-Schmidt , Serena Nelson , Shamina Rangwala , Shannon Mullican , Jose Antonio Chavez
IPC: A61K38/00 , A61K38/16 , A61K38/17 , A61K38/18 , A61K38/19 , C07K14/00 , C07K14/435 , C07K14/46 , C07K14/47 , C07K14/475 , C07K14/51 , C07K14/765 , C12N1/11 , C12N1/13 , C12N1/15 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/14 , C12N15/62 , C12N15/63 , C12N5/12
Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.
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公开(公告)号：US11208464B2
公开(公告)日：2021-12-28
申请号：US16412819
申请日：2019-05-15
Applicant: Janssen Biotech, Inc.
Inventor： Anthony Armstrong , Judith Ann Connor , Jennifer Furman , Chichi Huang , Michael J. Hunter , Xiefan Lin-Schmidt , Serena Nelson , Shamina M. Rangwala , Shannon Mullican , Jose Antonio Chavez
IPC: A61K38/19 , A61K38/17 , A61K38/18 , A61K38/16 , A61K38/00 , C07K14/765 , C07K14/51 , C07K14/47 , C07K14/435 , C07K14/46 , C12N5/12 , C12N15/00 , C12N15/11 , C12N15/63 , C12N15/09 , C12N15/62 , C07K14/475
Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.
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公开(公告)号：US20190234935A1
公开(公告)日：2019-08-01
申请号：US16341074
申请日：2017-10-11
Applicant: Janssen Biotech, Inc.
Inventor： Anthony Armstrong , Stephen Beck , Jose Antonio Chavez , Chen-Ni Chin , Thai Dinh , Jennifer Furman , Matt Husovsky , Xiefan Lin-Schmidt , Shannon Mullican , Shamina Rangwala , Vicki South
CPC classification number: G01N33/502 , A61K49/0008 , C12Q1/6883 , G01N2333/495
Abstract: A novel receptor for GDF15 was identified (GFRAL), as well as the use of this receptor in the identification or screening of GDF15 agonists or antagonists. These agonist or antagonist compounds may be used to either potentiate or suppress GDF15-like effects, respectively, at the cellular and organism levels, and may be used in treatment of metabolic diseases, including obesity, type 2 diabetes, hyperglycemia, hyperinsulinemia, dyslipidemia, diabetic nephropathy, or anorexia.
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公开(公告)号：US10208113B2
公开(公告)日：2019-02-19
申请号：US14745939
申请日：2015-06-22
Applicant: Janssen Biotech, Inc.
Inventor： Ellen Chi , Judith Connor , Chichi Huang , Jarrat Jordan , Xiefan Lin-Schmidt , Jinquan Luo , Lu Lu , Christian Martinez , Galina Obmolova , Ronald Swanson
Abstract: The present invention relates to antibodies that broady neutralize interferon-α and interferon-ω, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
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公开(公告)号：US09902770B2
公开(公告)日：2018-02-27
申请号：US14208861
申请日：2014-03-13
Applicant: Janssen Biotech, Inc.
Inventor： Ellen Chi , Judith Connor , Chichi Huang , Jarrat Jordan , Xiefan Lin-Schmidt , Jinquan Luo , Lu Lu , Christian Martinez , Galina Obmolova , Ronald Swanson
IPC: C07K16/24 , C07K16/46 , A61K39/395
CPC classification number: C07K16/249 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92
Abstract: Broadly neutralizing interferon-α and interferon-ω antibody antagonists, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing are useful in the treatment of diseases associated with increased production of IFNα and IFNω.
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