公开(公告)号：US20170327560A1

公开(公告)日：2017-11-16

申请号：US15586463

申请日：2017-05-04

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Judith Ann Connor ,  Jennifer Furman ,  Chichi Huang ,  Michael J. Hunter ,  Xiefan Lin-Schmidt ,  Serena Nelson ,  Shamina Rangwala ,  Shannon Mullican ,  Jose Antonio Chavez

IPC: C07K14/765 ,  C07K14/475 ,  A61K38/00

CPC classification number: C07K14/765 ,  A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/1875 ,  A61K38/19 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C07K14/475 ,  C07K14/51 ,  C07K2319/31 ,  C12N5/12 ,  C12N15/00 ,  C12N15/09 ,  C12N15/11 ,  C12N15/62 ,  C12N15/63

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

公开(公告)号：US10336812B2

公开(公告)日：2019-07-02

申请号：US15586463

申请日：2017-05-04

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Judith Ann Connor ,  Jennifer Furman ,  Chichi Huang ,  Michael J. Hunter ,  Xiefan Lin-Schmidt ,  Serena Nelson ,  Shamina Rangwala ,  Shannon Mullican ,  Jose Antonio Chavez

IPC: A61K38/00 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/19 ,  C07K14/00 ,  C07K14/435 ,  C07K14/46 ,  C07K14/47 ,  C07K14/475 ,  C07K14/51 ,  C07K14/765 ,  C12N1/11 ,  C12N1/13 ,  C12N1/15 ,  C12N1/21 ,  C12N5/10 ,  C12N15/00 ,  C12N15/09 ,  C12N15/11 ,  C12N15/12 ,  C12N15/14 ,  C12N15/62 ,  C12N15/63 ,  C12N5/12

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

公开(公告)号：US20190292241A1

公开(公告)日：2019-09-26

申请号：US16412819

申请日：2019-05-15

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Judith Ann Connor ,  Jennifer Furman ,  Chichi Huang ,  Michael J. Hunter ,  Xiefan Lin-Schmidt ,  Serena Nelson ,  Shamina M. Rangwala ,  Shannon Mullican ,  Jose Antonio Chavez

IPC: C07K14/765 ,  C12N15/62 ,  C12N15/09 ,  C07K14/475 ,  C12N15/63 ,  C12N15/11 ,  C12N15/00 ,  C12N5/12 ,  C07K14/46 ,  A61K38/16 ,  C07K14/435 ,  A61K38/18 ,  C07K14/47 ,  C07K14/51 ,  A61K38/17 ,  A61K38/19

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

公开(公告)号：US20180044427A1

公开(公告)日：2018-02-15

申请号：US15662866

申请日：2017-07-28

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Mark Chiu ,  Di Zhang

IPC: C07K16/28 ,  C07K16/30

Abstract: The present invention relates to engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions.

公开(公告)号：US11208464B2

公开(公告)日：2021-12-28

申请号：US16412819

申请日：2019-05-15

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Judith Ann Connor ,  Jennifer Furman ,  Chichi Huang ,  Michael J. Hunter ,  Xiefan Lin-Schmidt ,  Serena Nelson ,  Shamina M. Rangwala ,  Shannon Mullican ,  Jose Antonio Chavez

IPC: A61K38/19 ,  A61K38/17 ,  A61K38/18 ,  A61K38/16 ,  A61K38/00 ,  C07K14/765 ,  C07K14/51 ,  C07K14/47 ,  C07K14/435 ,  C07K14/46 ,  C12N5/12 ,  C12N15/00 ,  C12N15/11 ,  C12N15/63 ,  C12N15/09 ,  C12N15/62 ,  C07K14/475

Abstract: Fusion proteins containing a half-life extension protein, a linker, and a GDF15 protein are described. Also described are nucleic acids encoding the fusion proteins, recombinant cells thereof, compositions comprising the fusion proteins, and methods of using the fusion proteins for treating or preventing metabolic diseases, disorders or conditions.

公开(公告)号：US20190234935A1

公开(公告)日：2019-08-01

申请号：US16341074

申请日：2017-10-11

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Stephen Beck ,  Jose Antonio Chavez ,  Chen-Ni Chin ,  Thai Dinh ,  Jennifer Furman ,  Matt Husovsky ,  Xiefan Lin-Schmidt ,  Shannon Mullican ,  Shamina Rangwala ,  Vicki South

IPC: G01N33/50 ,  A61K49/00

CPC classification number: G01N33/502 ,  A61K49/0008 ,  C12Q1/6883 ,  G01N2333/495

Abstract: A novel receptor for GDF15 was identified (GFRAL), as well as the use of this receptor in the identification or screening of GDF15 agonists or antagonists. These agonist or antagonist compounds may be used to either potentiate or suppress GDF15-like effects, respectively, at the cellular and organism levels, and may be used in treatment of metabolic diseases, including obesity, type 2 diabetes, hyperglycemia, hyperinsulinemia, dyslipidemia, diabetic nephropathy, or anorexia.

公开(公告)号：US10669344B2

公开(公告)日：2020-06-02

申请号：US15662866

申请日：2017-07-28

Applicant: Janssen Biotech, Inc.

Inventor： Anthony Armstrong ,  Mark Chiu ,  Di Zhang

IPC: C07K16/28 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions.