Abstract:
An information need can be modeled by a binary classifier such as support vector machine (SVM). SVMs can exhibit very conservative precision oriented behavior when modeling information needs. This conservative behavior can be overcome by adjusting the position of the hyperplane, the geometric representation of a SVM. The present invention describes a couple of automatic techniques for adjusting the position of an SVM model based upon a beta-gamma thresholding procedure, cross fold validation and retrofitting. This adjustment technique can also be applied to other types of learning strategies.
Abstract:
A computer-readable medium comprises data structure for providing information about levels of similarity between pairs of N documents. The data structure comprises a plurality of entries of similarity values representing levels of similarity for a plurality of pairs of the documents. Each of the similarity values represents a level of similarity of one document of a given pair relative to the other document of the given pair. The similarity value of each entry is greater than a threshold similarity value that is greater than zero. The plurality of similarity-value entries are fewer than N2−N in number if the similarity values are asymmetric with regard to document pairing, and the plurality of similarity-value entries are fewer than N 2 - N 2 in number if the similarity values are symmetric with regard to document pairing. A method and apparatus for generating the data structure are described.
Abstract:
The invention relates in various aspects to a recombinant poxvirus comprising a nucleic acid encoding a SARS-CoV-2 virus protein, methods for producing such viruses and the use of such viruses. The recombinant poxviruses are well suited, among others, as protective virus vaccines against SARS-CoV-2 virus.
Abstract:
The invention relates to a lock-release method to be applied to biomolecules, such as antibodies, to improve the purification, production, stability and storage of biomolecules. A biomolecule is covalently bound to a polymer support comprising a diketone group so that the biomolecule can be purified, produced and/or stored before being released from the support. The diketone group of the polymer support is a 1,3-ketoester, 1,3-ketothioester or 1,3-ketoamide is a group of Formula (1): R1 is an optionally substituted hydrocarbyl, perhalogenated hydrocarbyl, or a heterocyclyl group; Y is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group; X is —O, —NR2 or —S, wherein the free valence of —O, —NR2 or —S is bonded to the support optionally via a linker; and R2 is hydrogen, an optionally substituted hydrocarbyl, or a heterocyclyl group. The invention also relates to a polymer support comprising the diketone group.
Abstract:
The present invention pertains to methods of preventing and eliminating trisulfide bonds in proteins such as antibodies. In one embodiment, trisulfide bonds in proteins are converted to disulfide bonds as part of chromatographic purification procedures. In another embodiment, the formation of trisulfide bonds in proteins is inhibited by implementation of methods described herein during the cell culture production of such proteins. In another embodiment, monoclonal antibodies are produced by the methods described herein.
Abstract:
The present invention relates to a new construction method for swimming pools, surfing pools, body boarding pools, wave pools, water park pools, kayaking and white water rafting courses and pools, wake boarding pools, water skiing pools and jet skiing pools, static surfing simulators, deep water river standing wave attractions. The present invention construction method can also be used in lagoons, ponds, lakes, and rivers. The invention will save construction costs, and save pool construction time.
Abstract:
The invention relates to a method and system for assessing a performance of a musical composition in relation to a model performance of the same composition. In particular, as even a model performance does not follow a score of a composition precisely, the present invention initially correlates the model performance to a score of the performed composition. This allows for an accurate assessment of the timing of the assessable performance, relative to the timing of the model performance. The invention is of particular use where the assessable performance is performed along with the model performance, but the two performances are remote from each other.
Abstract:
A multi-touch system is provided. The multi-touch system includes a multi-touch detection area generated by a mobile device and a first communication device, the mobile device and first or second communication device being movable relative to each other. The mobile device is operable to determine a first set of coordinates for a first detectable object within the multi-touch detection area as a function of: a distance between the mobile device and the first communication device, a distance between the mobile device and first detectable object, and a distance between the first communication device and first detectable object.