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1.发明授权SF-25 Colon adenocarcinoma antigen, and antibodies with recognize this antigen 失效SF-25 COLON ADENOCARCINOMA抗原和抗原鉴定这种抗原
公开(公告)号：US5212085A
公开(公告)日：1993-05-18
申请号：US203198
申请日：1988-06-07
Applicant: Jack R. Wands , Hiroshi Takahashi
Inventor： Jack R. Wands , Hiroshi Takahashi
IPC: G01N33/574 , A61K38/00 , A61K39/00 , A61K39/395 , A61K41/00 , A61K51/10 , A61P35/00 , C07K14/435 , C07K16/00 , C07K16/30 , C07K19/00 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/577
CPC classification number: A61K39/0011 , A61K51/1048 , A61K51/1093 , C07K16/3046 , A61K2123/00 , A61K38/00
Abstract: The present invention pertains to the SF-25 antigen of colon adenocarcinoma cells, to functional derivatives of this antigen, and to antibodies and antibody fragments capable of binding this antigen. The invention further discloses methods of diagnosing and treating colon cancer which employ the above molecules.
Abstract translation: 本发明涉及结肠腺癌细胞的SF-25抗原，该抗原的功能衍生物，以及能够结合该抗原的抗体和抗体片段。 本发明还公开了使用上述分子的诊断和治疗结肠癌的方法。
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公开(公告)号：US5703213A
公开(公告)日：1997-12-30
申请号：US193673
申请日：1994-02-07
Applicant: Jack R. Wands , Hiroshi Takahashi
Inventor： Jack R. Wands , Hiroshi Takahashi
IPC: A61K39/395 , A61K38/00 , A61K41/00 , A61K51/10 , C07K1/22 , C07K14/00 , C07K14/47 , C07K16/00 , C07K16/30 , C12N5/10 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/574 , G01N33/577 , C12N5/12 , C12N5/18
CPC classification number: C07K14/4748 , A61K41/0057 , A61K51/1048 , A61K51/1093 , C07K16/30 , A61K2123/00 , A61K38/00
Abstract: The present invention is directed to antibodies, and fragments thereof, which specifically bind the AF-20 and the XF-8 epitopes of adenocarcinoma cell antigen(s).
Abstract translation: 本发明涉及特异性结合腺癌细胞抗原的AF-20和XF-8表位的抗体及其片段。
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3.发明申请公开(公告)号：US20110076290A1
公开(公告)日：2011-03-31
申请号：US12842494
申请日：2010-07-23
Applicant: Masafumi Shimoda , Jack R. Wands
Inventor： Masafumi Shimoda , Jack R. Wands
IPC: A61K39/00 , C12N5/0784 , A61P35/00
CPC classification number: A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/545 , C12N5/0639 , C12N9/0071 , C12N2500/90 , C12N2501/22 , C12N2501/23 , C12N2501/24 , C12N2501/52
Abstract: A vaccine containing AAH-loaded mature dendritic cells for treatment of AAH-expressing tumors in mammalian subjects. A method of producing primed dendritic cells is carried out by contacting isolated dendritic cells with an antigen such as AAH. Following the antigen-contacting step, the dendritic cells are contacted with a combination of cytokines such as GM-CSF and IFN-γ.
Abstract translation: 含有AAH的成熟树突细胞用于治疗哺乳动物受试者中表达AAH的肿瘤的疫苗。 通过使分离的树突状细胞与抗原例如AAH接触来制备引发树突状细胞的方法。 在抗原接触步骤之后，将树突状细胞与细胞因子如GM-CSF和IFN-γ的组合接触。
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公开(公告)号：US07867705B2
公开(公告)日：2011-01-11
申请号：US11575627
申请日：2005-01-05
Applicant: Jack R. Wands , Philippe Merle , Suzanne M. De La Monte
Inventor： Jack R. Wands , Philippe Merle , Suzanne M. De La Monte
CPC classification number: C07K14/82 , A01K67/0275 , A01K2217/052 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , A61K38/179 , C07K16/28 , C07K2317/34 , C12N2710/22022 , C12N2730/10122 , G01N33/5067 , G01N33/57438 , G01N2500/00
Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
Abstract translation: 本说明书尤其提供了在癌症诊断和治疗中使用Wnt和FZD蛋白，基因，FZD和Wnt特异性抗体和探针并用于筛选测试化合物以治疗癌症的方法。 还公开了可用于治疗癌症如肝癌的化合物。
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公开(公告)号：US20080194457A1
公开(公告)日：2008-08-14
申请号：US11575627
申请日：2005-01-05
Applicant: Jack R. Wands , Philippe Merle , Suzanne M. De La Monte
Inventor： Jack R. Wands , Philippe Merle , Suzanne M. De La Monte
IPC: A61K38/00 , C12Q1/68 , G01N33/574 , A01K67/027 , A61P1/00 , G01N33/566 , C12N5/06 , A61K31/70
CPC classification number: C07K14/82 , A01K67/0275 , A01K2217/052 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , A61K38/179 , C07K16/28 , C07K2317/34 , C12N2710/22022 , C12N2730/10122 , G01N33/5067 , G01N33/57438 , G01N2500/00
Abstract: The present specification provides, inter alia, methods of using Wnt and FZD proteins, genes, FZD and Wnt-specific antibodies and probes in diagnosis and treatment of cancer and for screening test compounds for an ability to treat cancer. Also disclosed are compounds useful for treating cancer such as liver cancer.
Abstract translation: 本说明书尤其提供了在癌症诊断和治疗中使用Wnt和FZD蛋白，基因，FZD和Wnt特异性抗体和探针并用于筛选测试化合物以治疗癌症的方法。 还公开了可用于治疗癌症如肝癌的化合物。
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Patent Agency Ranking
公开(公告)号：US07122541B2
公开(公告)日：2006-10-17
申请号：US10873802
申请日：2004-06-21
Applicant: Jack R. Wands , Rolf I. Carlson , Paul Maggio
Inventor： Jack R. Wands , Rolf I. Carlson , Paul Maggio
IPC: A61K31/54
CPC classification number: A61K31/549 , Y10S514/893
Abstract: The invention relates to methods for preventing and treating disseminating cancers. Inhibition metastases of a primary tumor to a liver tissue is carried out by directly contacting a liver tissue with Taurolidine.
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公开(公告)号：US06812206B2
公开(公告)日：2004-11-02
申请号：US09903216
申请日：2001-07-11
Applicant: Jack R. Wands , Suzanne M. de la Monte , Nedim Ince , Rolf I. Carlson
Inventor： Jack R. Wands , Suzanne M. de la Monte , Nedim Ince , Rolf I. Carlson
IPC: A61K39395
CPC classification number: C12N15/1137 , A61K31/00 , A61K31/4412 , A61K2039/505 , C07K14/47 , C07K16/40 , C12N9/0071 , C12N2310/111 , C12N2310/315 , C12N2799/027 , C12Q1/26 , C12Y114/11016 , G01N33/574 , G01N33/57484 , G01N2500/00 , G01N2500/10
Abstract: The invention features a method for diagnosing a malignant neoplasm in a mammal by contacting a bodily fluid from the mammal with an antibody which binds to an human aspartyl (asparaginyl) beta-hydroxylase (HAAH) polypeptide and methods of treating malignant neoplasms by inhibiting HAAH.
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公开(公告)号：US5610050A
公开(公告)日：1997-03-11
申请号：US51935
申请日：1993-04-23
Applicant: Hubert E. Blum , Tsanyang Liang , Eithan Galun , Jack R. Wands
Inventor： Hubert E. Blum , Tsanyang Liang , Eithan Galun , Jack R. Wands
IPC: A61K38/00 , A61K48/00 , C07H21/00 , C07K14/02 , C12N7/04 , C12N9/12 , C12N15/113 , C12N7/06 , C07H21/04
CPC classification number: A61K31/70 , A61K48/00 , C07H21/00 , C07K14/005 , C12N15/1131 , C12N7/00 , C12N9/1276 , A61K38/00 , C12N2710/10123 , C12N2730/10122 , C12N2730/10161
Abstract: The invention relates to methods and compositions for inhibition of viral replication. In particular, termination of replication of hepatitis B virus is achieved by introducing into a target cell an antisense oligonucleotide having a sequence substantially complementary to an mRNA which is in turn complementary to a portion of the minus strand of a hepatitis viral genome, which portion encoding solely part or all of the terminal protein region of the viral polymerase.
Abstract translation: 本发明涉及用于抑制病毒复制的方法和组合物。 特别地，乙型肝炎病毒的复制终止是通过向目标细胞中引入具有与mRNA基本互补的序列的反义寡核苷酸来实现的，所述序列又与肝炎病毒基因组的负链的一部分互补，所述部分编码 仅仅是病毒聚合酶的部分或全部的末端蛋白质区域。
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公开(公告)号：US09687537B2
公开(公告)日：2017-06-27
申请号：US12842494
申请日：2010-07-23
Applicant: Masafumi Shimoda , Jack R. Wands
Inventor： Masafumi Shimoda , Jack R. Wands
IPC: A61K39/00 , A61K35/00 , C12N5/0784 , C12N9/02
CPC classification number: A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/545 , C12N5/0639 , C12N9/0071 , C12N2500/90 , C12N2501/22 , C12N2501/23 , C12N2501/24 , C12N2501/52
Abstract: A vaccine containing AAH-loaded mature dendritic cells for treatment of AAH-expressing tumors in mammalian subjects. A method of producing primed dendritic cells is carried out by contacting isolated dendritic cells with an antigen such as AAH. Following the antigen-contacting step, the dendritic cells are contacted with a combination of cytokines such as GM-CSF and IFN-γ.
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公开(公告)号：US20090280192A1
公开(公告)日：2009-11-12
申请号：US12505868
申请日：2009-07-20
Applicant: Robert W. Esmond , Jack R. Wands
Inventor： Robert W. Esmond , Jack R. Wands
CPC classification number: A61K38/30 , A61K31/00 , A61K31/28 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/48 , A61K31/4985 , A61K33/24
Abstract: Disclosed is a method for treating or preventing Alzheimer's disease by restricting the level of metabolizable carbohydrate in the diet and/or administering to the patient an effective amount of an agent which reduces serum insulin levels.
Abstract translation: 公开了一种通过限制饮食中可代谢的碳水化合物的水平和/或向患者施用有效量的降低血清胰岛素水平的药物来治疗或预防阿尔茨海默氏病的方法。
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