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    METHOD, APPARATUS AND SYSTEM FOR VALIDATING AND QUANTIFYING CARDIAC BEAT DATA QUALITY
    1.
    发明申请
    METHOD, APPARATUS AND SYSTEM FOR VALIDATING AND QUANTIFYING CARDIAC BEAT DATA QUALITY 有权
    方法，装置和系统，用于验证和量化心脏数据质量

    公开(公告)号：US20110270346A1

    公开(公告)日：2011-11-03

    申请号：US12771727

    申请日：2010-04-30

    Applicant: Mark Frei ,  Ivan Osorio

    Inventor： Mark Frei ,  Ivan Osorio

    IPC: A61N1/36

    CPC classification number: A61B5/4094 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/0456 ,  A61N1/36053 ,  A61N1/36064 ,  A61N1/36139

    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test. In one class of beat validity test, a constraint defining a pass is modified at one or more times after the most recent prior valid heart beat that is greater than a constraint modification time threshold

    Abstract translation: 用于量化候选心跳的基准时间标记的质量的方法，系统和装置，量化候选心跳的质量或确定患者心脏的搏动序列的时间。 获得候选心跳的基准时间标记。 将所述候选心跳的质量指标设定为第一值。 通过至少一次拍子有效性测试来测试候选心跳。 如果所述候选心跳通过所述至少一个节拍有效性测试，则至少将第二值添加到所述候选心跳的所述质量指标。 使用至少第二次心跳有效性测试来测试候选心跳。 如果所述候选心跳通过所述至少第二次心跳有效性测试，则至少第三值被添加到所述候选心跳的所述质量指标。 在一类节拍有效性测试中，定义通行证的约束在最近的有效心跳之后的一个或多个时间被修改，其大于约束修改时间阈值

    System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject
    2.
    发明申请
    System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject 审中-公开
    用于预测，快速检测，警告，预防或控制受试者大脑活动状态变化的系统

    公开(公告)号：US20100198098A1

    公开(公告)日：2010-08-05

    申请号：US12592990

    申请日：2009-12-05

    Applicant: Ivan Osorio ,  Mark Frei ,  David Lerner ,  John Ralston ,  Josef Dorfmeister

    Inventor： Ivan Osorio ,  Mark Frei ,  David Lerner ,  John Ralston ,  Josef Dorfmeister

    IPC: A61B5/0476

    CPC classification number: A61B5/048 ,  A61B5/4094 ,  A61B5/7257 ,  A61B5/726 ,  A61N1/08 ,  A61N1/36064 ,  A61N1/36082

    Abstract: A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.

    Abstract translation: 系统（10）在信号处理器（12）中分析表示受试者的大脑活动的信号，用于指示受试者的当前活动状态的信息，以及用于预测活动状态的变化。 一个优选实施例使用非线性滤波方法的组合来执行来自对象患者的电脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成 至少在临床癫痫发作前需要进行分析。 优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

    CLUSTERING OF RECORDED PATIENT NEUROLOGICAL ACTIVITY TO DETERMINE LENGTH OF A NEUROLOGICAL EVENT
    3.
    发明申请
    CLUSTERING OF RECORDED PATIENT NEUROLOGICAL ACTIVITY TO DETERMINE LENGTH OF A NEUROLOGICAL EVENT 有权
    记录患者神经活动的聚集，以确定神经病学活动的长度

    公开(公告)号：US20080064934A1

    公开(公告)日：2008-03-13

    申请号：US11837987

    申请日：2007-08-13

    Applicant: Mark Frei ,  Ivan Osorio ,  Nina Graves ,  Scott Schaffner ,  Mark Rise ,  Jonathon Giftakis ,  David Carlson

    Inventor： Mark Frei ,  Ivan Osorio ,  Nina Graves ,  Scott Schaffner ,  Mark Rise ,  Jonathon Giftakis ,  David Carlson

    IPC: A61B5/00 ,  A61M5/00 ,  A61N1/36

    CPC classification number: A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

    Abstract: Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

    Abstract translation: 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

    Signal Quality Monitoring And Control For A Medical Device System
    4.
    发明申请
    Signal Quality Monitoring And Control For A Medical Device System 有权
    医疗器械系统信号质量监测与控制

    公开(公告)号：US20070100278A1

    公开(公告)日：2007-05-03

    申请号：US11557433

    申请日：2006-11-07

    Applicant: Mark Frei ,  Ivan Osorio

    Inventor： Mark Frei ,  Ivan Osorio

    IPC: A61M31/00 ,  A61B18/18 ,  A61N1/00 ,  A61B5/00 ,  A61B5/04

    CPC classification number: A61B5/04012 ,  A61B5/048 ,  A61B5/4094 ,  A61B5/7203 ,  A61B5/7217 ,  A61B5/7221 ,  A61N1/36014 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/36135 ,  A61N1/3702 ,  A61N1/37229 ,  A61N1/37252

    Abstract: Method and apparatus for detecting possible interference in a neurological signal received from a monitoring element of a medical device system. The monitoring element monitors a condition or a symptom of a nervous system disorder being treated and provides a neurological signal to the medical device system for purposes of providing closed-loop feedback control. The system analyzes various parameters of the received signal by taking instantaneous measurements of data points in moving window and thereby determining whether the signal is of poor quality. If the signal is of determined poor quality, it is removed from consideration in the closed-loop feedback control system until it is determined that the signal quality has sufficiently been restored.

    Abstract translation: 用于检测从医疗装置系统的监视元件接收的神经信号中的可能的干扰的方法和装置。 监测元件监测被治疗的神经系统疾病的状况或症状，并且为了提供闭环反馈控制的目的而向医疗装置系统提供神经信号。 该系统通过对移动窗口中的数据点进行瞬时测量，从而确定信号质量差，分析接收信号的各种参数。 如果信号确定质量差，则在闭环反馈控制系统中将其去除，直到确定信号质量已被充分恢复为止。

    Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale
    5.
    发明申请
    Method, computer program, and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale 有权
    方法，计算机程序和系统，用于任意原点或时间尺度信号的固有时间尺度分解，滤波和自动分析

    公开(公告)号：US20070030002A1

    公开(公告)日：2007-02-08

    申请号：US11415064

    申请日：2006-05-01

    Applicant: Mark Frei ,  Ivan Osorio

    Inventor： Mark Frei ,  Ivan Osorio

    IPC: G01V3/00

    CPC classification number: G06K9/00503 ,  G06F17/14 ,  G06K9/00523

    Abstract: A method and system for intrinsic timescale decomposition, filtering, and automated analysis of signals of arbitrary origin or timescale including receiving an input signal, determining a baseline segment and a monotonic residual segment with strictly negative minimum and strictly positive maximum between two successive extrema of the input signal, and producing a baseline output signal and a residual output signal. The method and system also includes determining at least one instantaneous frequency estimate from a proper rotation signal, determining a zero-crossing and a local extremum of the proper rotation signal, and applying interpolation thereto to determine an instantaneous frequency estimate thereof. The method and system further includes determining at least one instantaneous frequency estimate from a proper rotation signal, extracting an amplitude-normalized half wave therefrom and applying an arcsine function to the amplitude-normalized half wave to determine an instantaneous frequency estimate of the proper rotation signal.

    Abstract translation: 用于固有时间尺度分解，过滤和任意来源或时间尺度信号的自动分析的方法和系统，包括接收输入信号，确定基线段和具有严格为负的最小值和严格正数最大值的两个连续极值之间的单调残差段 输入信号，并产生基线输出信号和残留输出信号。 所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，确定适当旋转信号的过零点和局部极值，并对其进行插值以确定其瞬时频率估计。 所述方法和系统还包括从适当的旋转信号确定至少一个瞬时频率估计，从其中提取幅度归一化的半波，并对所述幅度归一化的半波应用反正弦函数，以确定适当旋转信号的瞬时频率估计 。

    System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject
    6.
    发明授权
    System for the prediction, rapid detection, warning, prevention or control of changes in activity states in the brain of a subject 有权
    用于预测，快速检测，警告，预防或控制受试者大脑活动状态变化的系统

    公开(公告)号：US06549804B1

    公开(公告)日：2003-04-15

    申请号：US09329593

    申请日：1999-06-10

    Applicant: Ivan Osorio ,  Mark Frei ,  David Lerner ,  John Ralston ,  Josef Dorfmeister

    Inventor： Ivan Osorio ,  Mark Frei ,  David Lerner ,  John Ralston ,  Josef Dorfmeister

    IPC: A61B504

    CPC classification number: A61B5/415 ,  A61B5/048 ,  A61B5/4094 ,  A61B5/7257 ,  A61B5/726 ,  A61N1/08 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36135 ,  G06F19/00

    Abstract: A system (10) analyzes signals representative of a subject's brain activity in a signal processor (12) for information indicating the subject's current activity state and for predicting a change in the activity state. One preferred embodiment uses a combination of nonlinear filtering methods to perform real-time analysis of the electro-encephalogram (EEG) or electro-corticogram (ECoG) signals from a subject patient for information indicative of or predictive of a seizure, and to complete the needed analysis at least before clinical seizure onset. The preferred system then performs an output task for prevention or abatement of the seizure, or for recording pertinent data.

    Abstract translation: 系统（10）在信号处理器（12）中分析表示受试者的大脑活动的信号，用于指示受试者的当前活动状态的信息，以及用于预测活动状态的变化。 一个优选实施例使用非线性滤波方法的组合来执行来自对象患者的电脑电图（EEG）或电皮质图（ECoG）信号的实时分析，用于指示或预测癫痫发作的信息，并且完成 至少在临床癫痫发作前需要进行分析。 优选的系统然后执行输出任务以防止或减少缉获量，或用于记录相关数据。

    VALIDITY TEST ADAPTIVE CONSTRAINT MODIFICATION FOR CARDIAC DATA USED FOR DETECTION OF STATE CHANGES
    9.
    发明申请
    VALIDITY TEST ADAPTIVE CONSTRAINT MODIFICATION FOR CARDIAC DATA USED FOR DETECTION OF STATE CHANGES 有权
    用于检测状态变化的心脏数据的有效性测试自适应约束修改

    公开(公告)号：US20110270347A1

    公开(公告)日：2011-11-03

    申请号：US12771783

    申请日：2010-04-30

    Applicant: Mark Frei ,  Ivan Osorio

    Inventor： Mark Frei ,  Ivan Osorio

    IPC: A61N1/36

    CPC classification number: A61N1/36064 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/0456 ,  A61B5/4094 ,  A61N1/36053 ,  A61N1/3606 ,  A61N1/36139

    Abstract: Methods, systems, and apparatus for quantifying the quality of a fiducial time marker for a candidate heart beat, quantifying the quality of a candidate heart beat, or determining a time of beat sequence of the patient's heart. A fiducial time marker is obtained for a candidate heart beat. A quality index of said candidate heart beat is set to a first value. The candidate heart beat is tested with at least one beat validity test. At least a second value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least one beat validity test. The candidate heart beat is tested with at least a second heart beat validity test. At least a third value is added to said quality index of said candidate heart beat if said candidate heart beat passes said at least second heart beat validity test. In one class of beat validity test, a constraint defining a pass is modified at one or more times after the most recent prior valid heart beat that is greater than a constraint modification time threshold

    Abstract translation: 用于量化候选心跳的基准时间标记的质量的方法，系统和装置，量化候选心跳的质量或确定患者心脏的搏动序列的时间。 获得候选心跳的基准时间标记。 将所述候选心跳的质量指标设定为第一值。 通过至少一次拍子有效性测试来测试候选心跳。 如果所述候选心跳通过所述至少一个节拍有效性测试，则至少将第二值添加到所述候选心跳的所述质量指标。 使用至少第二次心跳有效性测试测试候选心跳。 如果所述候选心跳通过所述至少第二次心跳有效性测试，则至少第三值被添加到所述候选心跳的所述质量指标。 在一类节拍有效性测试中，定义通行证的约束在最近的有效心跳之后的一个或多个时间被修改，其大于约束修改时间阈值

    Implantable interface for a medical device system
    10.
    发明申请
    Implantable interface for a medical device system 有权
    用于医疗设备系统的可植入界面

    公开(公告)号：US20070272260A1

    公开(公告)日：2007-11-29

    申请号：US11414736

    申请日：2006-04-28

    Applicant: Alexei Nikitin ,  Ivan Osorio ,  Mark Frei ,  Naresh Bhavaraju

    Inventor： Alexei Nikitin ,  Ivan Osorio ,  Mark Frei ,  Naresh Bhavaraju

    IPC: A61B19/00

    CPC classification number: A61N1/0529 ,  A61M5/14276 ,  A61M5/16827 ,  A61M5/16881 ,  A61M2205/054 ,  A61M2205/3507 ,  A61M2210/0693 ,  A61N1/36082

    Abstract: An implantable interface system for a medical device system providing selective interconnectivity between conduits and therapy elements. The interface system contains connecting elements that each provide a robust connection between a selected conduit and a selected therapy element. The interface system enables the use of a surplus of therapy elements so that treatment to the same site (in the case of electrode migration or failure), or to different sites but within the spatial domain of the interface's elements may be delivered through the spare/excess therapy elements without the need for additional major surgical procedures.

    Abstract translation: 一种用于医疗装置系统的可植入界面系统，其提供导管和治疗元件之间的选择性互连。 接口系统包含连接元件，每个连接元件在所选导管和选定的治疗元件之间提供牢固的连接。 接口系统使得能够使用多余的治疗元件，使得可以通过备用/非接触式的治疗单元向相同部位（在电极迁移或失效的情况下）或不同部位但在界面元件的空间域内进行治疗， 多余的治疗元素，而不需要额外的主要外科手术。

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