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    MUTANT GLUCOSE DEHYDROGENASE
    1.
    发明申请
    MUTANT GLUCOSE DEHYDROGENASE 有权

    公开(公告)号：US20100086989A1

    公开(公告)日：2010-04-08

    申请号：US12556142

    申请日：2009-09-09

    申请人： Hideaki Yamaoka ,  Masashi Tsukada

    发明人： Hideaki Yamaoka ,  Masashi Tsukada

    IPC分类号： C07H21/04 ,  C12N1/21

    CPC分类号： C12Q1/32 ,  C12N9/0006 ,  C12Q1/54 ,  C12Y101/01049

    摘要： A mutant glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence of SEQ ID NO: 3 including substitution, deletion, insertion or addition of one or more amino acid residues other than the amino acid residue at the 365th position and having glucose dehydrogenase activity, wherein an amino acid residue at a position corresponding to the 365th position of, the amino acid sequence is replaced with another amino acid residue, and the mutant glucose dehydrogenase shows an improved substrate specificity to glucose.

    摘要翻译： 具有SEQ ID NO：3的氨基酸序列或SEQ ID NO：3的氨基酸序列的突变体葡萄糖脱氢酶，包括在第365天除了氨基酸残基之外的一个或多个氨基酸残基的取代，缺失，插入或添加 位置并且具有葡萄糖脱氢酶活性，其中与氨基酸序列的第365位相对应的位置的氨基酸残基被另一氨基酸残基替代，并且突变型葡萄糖脱氢酶显示出对葡萄糖的底物特异性改善。

    Mutant glucose dehydrogenase
    2.
    发明授权
    Mutant glucose dehydrogenase 有权
    突变葡萄糖脱氢酶

    公开(公告)号：US07604969B2

    公开(公告)日：2009-10-20

    申请号：US11665296

    申请日：2006-06-12

    申请人： Hideaki Yamaoka ,  Masashi Tsukada

    发明人： Hideaki Yamaoka ,  Masashi Tsukada

    IPC分类号： C12N9/04 ,  C12Q1/32 ,  C12Q1/00 ,  C12P21/04 ,  C12N1/20 ,  C12N15/00 ,  C07H21/04 ,  C12Q1/68

    CPC分类号： C12Q1/32 ,  C12N9/0006 ,  C12Q1/54 ,  C12Y101/01049

    摘要： A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having the substitution, deletion, insertion or addition of one or more amino acid residues excluding amino acid 365 in the amino acid sequence depicted in SEQ ID NO:3 and having a glucose dehydrogenase activity, the amino acid residue corresponding to amino acid 365 being substituted by other amino acid residue.

    摘要翻译： 具有改善的对葡萄糖的底物特异性的突变体葡萄糖脱氢酶，其是包含SEQ ID NO：3所示的氨基酸序列的蛋白质或具有取代，缺失，插入或添加一个或多个氨基酸残基的氨基酸序列， SEQ ID NO：3所示的氨基酸序列中的氨基酸365，具有葡萄糖脱氢酶活性，对应于氨基酸365的氨基酸残基被其它氨基酸残基取代。

    Mutant Glucose Dehydrogenase
    3.
    发明申请
    Mutant Glucose Dehydrogenase 有权
    突变型葡萄糖脱氢酶

    公开(公告)号：US20080206833A1

    公开(公告)日：2008-08-28

    申请号：US11665296

    申请日：2006-06-12

    申请人： Hideaki Yamaoka ,  Masashi Tsukada

    发明人： Hideaki Yamaoka ,  Masashi Tsukada

    IPC分类号： C12N9/04 ,  C07H21/04 ,  C12N1/00

    CPC分类号： C12Q1/32 ,  C12N9/0006 ,  C12Q1/54 ,  C12Y101/01049

    摘要： A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having the substitution, deletion, insertion or addition of one or more amino acid residues excluding amino acid 365 in the amino acid sequence depicted in SEQ ID NO:3 and having a glucose dehydrogenase activity, the amino acid residue corresponding to amino acid 365 being substituted by other amino acid residue.

    摘要翻译： 具有改善的对葡萄糖的底物特异性的突变体葡萄糖脱氢酶，其是包含SEQ ID NO：3所示的氨基酸序列的蛋白质或具有取代，缺失，插入或添加一个或多个氨基酸残基的氨基酸序列， SEQ ID NO：3所示的氨基酸序列中的氨基酸365，具有葡萄糖脱氢酶活性，对应于氨基酸365的氨基酸残基被其它氨基酸残基取代。

    Analysis Device and Analysis Method
    4.
    发明申请
    Analysis Device and Analysis Method 审中-公开
    分析装置与分析方法

    公开(公告)号：US20120116706A1

    公开(公告)日：2012-05-10

    申请号：US13381598

    申请日：2010-06-25

    申请人： Hiroyuki Nakanishi ,  Yoshiharu Uehata ,  Masako Kawanishi ,  Yosuke Murase ,  Masashi Tsukada

    发明人： Hiroyuki Nakanishi ,  Yoshiharu Uehata ,  Masako Kawanishi ,  Yosuke Murase ,  Masashi Tsukada

    IPC分类号： G06F19/00

    CPC分类号： A61B5/14532 ,  A61B5/14865 ,  A61B2560/0252 ,  G01N27/3274

    摘要： Provided is an analysis device or an analysis method, by which highly reliable analysis results can be obtained even in the circumstances where environment temperature changes, while reducing load on the user. The analysis device (1) is provided with a determining means (13) which determines whether environmental temperature measured by means of a temperature measuring means (6) is within a predetermined temperature range or not. The determining means (13) is so configured as to determine whether the environmental temperature is within the predetermined temperature range or not, even in the circumstances where information relating to a target substance in a sample cannot be obtained from the analysis device.

    摘要翻译： 提供了一种分析装置或分析方法，即使在环境温度变化的情况下也可以获得高度可靠的分析结果，同时减轻用户的负担。 分析装置（1）具有确定装置（13），其确定通过温度测量装置（6）测量的环境温度是否处于预定温度范围内。 即使在从分析装置不能获得与样本中的目标物质有关的信息的情况下，判定装置（13）被配置为确定环境温度是否在预定温度范围内。

    Analysis Device
    5.
    发明申请
    Analysis Device 有权
    分析装置

    公开(公告)号：US20120273368A1

    公开(公告)日：2012-11-01

    申请号：US13455555

    申请日：2012-04-25

    申请人： Masashi Tsukada

    发明人： Masashi Tsukada

    IPC分类号： G01N27/30 ,  G01N27/26 ,  G01N27/327

    CPC分类号： G01N27/3271 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3273 ,  G01N2333/902 ,  G01N2333/904

    摘要： An analysis device is disclosed which includes an electron detection medium to obtain information needed for analyzing an analyte in correlation with an electron transfer level, and a reagent part which is disposed on the electron detection medium and includes an electron transporting substance to transport electrons between the analyte and the electron detection medium, the electron transporting substance including a water-soluble aromatic heterocycle compound, and being free of a metal complex. An analysis method using the analysis device is also disclosed.

    摘要翻译： 公开了一种分析装置，其包括电子检测介质，以获得与电子转移水平相关的分析物所需的信息;以及试剂部件，其设置在电子检测介质上并且包括电子传输物质以在 分析物和电子检测介质，电子传输物质包括水溶性芳族杂环化合物，并且不含金属络合物。 还公开了使用分析装置的分析方法。

    MEASURING APPARATUS AND SENSOR PLACEMENT METHOD
    6.
    发明申请
    MEASURING APPARATUS AND SENSOR PLACEMENT METHOD 审中-公开
    测量装置和传感器放置方法

    公开(公告)号：US20120259192A1

    公开(公告)日：2012-10-11

    申请号：US13518820

    申请日：2010-11-25

    申请人： Masashi Tsukada ,  Yasuhide Kusaka ,  Akihiro Yamamoto

    发明人： Masashi Tsukada ,  Yasuhide Kusaka ,  Akihiro Yamamoto

    IPC分类号： A61B5/145

    CPC分类号： A61B5/14532 ,  A61B5/1486 ,  A61B5/7207 ,  A61B2560/063

    摘要： Provided are a measurement device, a sensor unit, and a sensor placement method, which enable the suppression of the occurrence of a situation where a measurement carried out with a sensor implanted under the skin, the implanted sensor becomes faulty. A sensor unit is used for measuring numerical information relating to a substance contained in a body fluid in a body. The sensor unit is provided with a sensor a part of which is placed under the skin and generates a signal according to the state of the substance, a base which is disposed on the skin and holds the sensor, a variable mechanism which is attached to the base and enables the position and/or the direction of the sensor with reference to the base to be varied, and an external terminal which is provided in the base and leads the signal generated by the sensor to the outside.

    摘要翻译： 提供了一种测量装置，传感器单元和传感器放置方法，其能够抑制通过植入在皮肤下的传感器进行的测量的发生的情况，植入的传感器变得有缺陷。 传感器单元用于测量与体内体液中所含物质有关的数值信息。 传感器单元设置有传感器，其一部分放置在皮肤下面并根据物质的状态产生信号，设置在皮肤上并保持传感器的基座，可变机构，其附接到 并且使得能够相对于基座改变传感器的位置和/或方向，以及设置在基座中并将由传感器产生的信号引导到外部的外部端子。

    Opening and closing type interior device
    7.
    发明授权
    Opening and closing type interior device 有权
    开闭式室内装置

    公开(公告)号：US06295883B1

    公开(公告)日：2001-10-02

    申请号：US09417780

    申请日：1999-10-14

    申请人： Masashi Tsukada ,  Kenichi Oji

    发明人： Masashi Tsukada ,  Kenichi Oji

    IPC分类号： F16H1908

    CPC分类号： B60K35/00 ,  B60K2350/405 ,  Y10T74/18816 ,  Y10T74/19623 ,  Y10T74/19637

    摘要： An opening and closing type interior device includes a fixed member, a movable member which is capable of being opened and closed and is movable relative to the fixed member, an actuator including a driving source and a gear mechanism, and a damper coupled to one of the movable member and the fixed member. The opening and closing type interior device includes, for example, a display device for an automobile.

    摘要翻译： 一种打开和关闭型内部装置，包括固定构件，能够被打开和关闭并且可相对于固定构件移动的可动构件，包括驱动源和齿轮机构的致动器以及耦合到 可动构件和固定构件。 打开和关闭型内部装置例如包括用于汽车的显示装置。

    Analysis device
    9.
    发明授权
    Analysis device 有权
    分析装置

    公开(公告)号：US09045790B2

    公开(公告)日：2015-06-02

    申请号：US13455555

    申请日：2012-04-25

    申请人： Masashi Tsukada

    发明人： Masashi Tsukada

    IPC分类号： G01N27/30 ,  G01N27/26 ,  G01N27/327 ,  C12Q1/00

    CPC分类号： G01N27/3271 ,  C12Q1/004 ,  C12Q1/006 ,  G01N27/3273 ,  G01N2333/902 ,  G01N2333/904

    摘要： An analysis device is disclosed which includes an electron detection medium to obtain information needed for analyzing an analyte in correlation with an electron transfer level, and a reagent part which is disposed on the electron detection medium and includes an electron transporting substance to transport electrons between the analyte and the electron detection medium, the electron transporting substance including a water-soluble aromatic heterocycle compound, and being free of a metal complex. An analysis method using the analysis device is also disclosed.

    摘要翻译： 公开了一种分析装置，其包括电子检测介质，以获得与电子转移水平相关的分析物所需的信息;以及试剂部件，其设置在电子检测介质上并且包括电子传输物质以在 分析物和电子检测介质，电子传输物质包括水溶性芳族杂环化合物，并且不含金属络合物。 还公开了使用分析装置的分析方法。